Trimethylglycine (TMG) is a molecule produced naturally in the body and it plays an important role in the methylation process. Proper methylation is vital for healthy aging and the prevention of aging-relating conditions. ⑴
Causes Of Methylation Issues
An inefficient methylation cycle can be caused by nutrient deficiencies, genetic mutations and physical or environmental stressors.
Many adults in the U.S. have a common genetic defect called MTHFR that reduces the function of a key enzyme involved in the methylation process.
Aging and Methylation Issues
DNA methylation is necessary for your genes to function properly. When the methylation process encounters issues, it can result in a variety of health conditions. Studies have shown that methylation greatly decreases as people age.
"Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease." ⑵
"An abundance of evidence indicates that reversal of aberrant DNA methylation could be an effective strategy to suppress disease and promote longevity."⑹
Nutrients to Support Methylation
Supplemental nutrients like TMG can support healthy methylation, which plays an important role in regulatinglevels.
Why Homocysteine Levels Matter
High levels of homocysteine are associated with a wide range of illnesses and serious medical conditions. Numerous studies have shown that treatment with TMG can lower plasma homocysteine levels.
"We conclude that doses of betaine (Trimethylglycine) in the range of dietary intake can substantially lower fasting plasma homocysteine."⑺
Elevated NAM and Methylation Issues
When taking standard NMN or NR, the compounds are almost entirely degraded to NAMbefore reaching tissues beyond the liver. This can become a problem if taking excessive doses of it.
In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.
“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” ⑻
TMG Restores Methylation Levels for Healthy Aging
Methylation imbalances due to aging or high NAM levels can lead to depleted methyl donors. TMG is commonly taken to help restore methylation levels and promote healthy aging.