NMN – 60 Ct. x 250 mg Enteric (Delayed Release) Capsules – RENUE BY SCIENCE – Bioavailable NAD+ Boosters

NMN – 60 Ct. x 250 mg Enteric (Delayed Release) Capsules

$24.95

Aids absorption via the SLC12a8 Transporter

  • Impervious to low pH (acidic) environment
  • Acid Resistant Enteric Capsules
  • Protects NMN from digestion by bacteria in stomach
  • Sodium Bicarbonate – Maximizes absorption
  • TMG – Methyl Replacement
  • Zinc – Increases Immunity

Why SLC NMN?

Research has increasingly shown that NAD+ and it’s precursors are almost entirely digested in the gastrointestinal tract.  So, in 2017 we quit selling capsules to focus on powders and tablets designed for sublingual use, even though we were the biggest seller of NAD+ boosting capsules on Amazon and through our website.

Then, two research studies were published in 2019 and 2020. The first showed the SLC12a8 enzyme prevalent in the small intestine can transport some NMN directly into cells as NAD+. The second shows that bacteria in the stomach actually consume nearly all NMN BEFORE it reaches the small intestine.

So we designed our SLC NMN with an Enteric (Delayed Release) capsule that dissolves only when reaching the high pH (base) environment of the small intestine. The NMN can then utilize the SLC12a8 transporter in far greater quantity, along with other ingredients added to maximize uptake by the SLC12a8 enzyme.

Bioavailability Problem with Standard Capsules

The 2018 Liu/Rabinowitz study found that very little, if any, NMN or NR make it past the liver into the bloodstream.

Even more striking, this 2020 study found most NMN never makes it to the liver, but is almost completely digested by bacteria in the stomach.

The yellow and red bars show NMN and NAD+ in the gastrointestinal tract are many times higher in mice given antibiotics (ABX) or NMN + Antibiotics (NMN + ABX).

This explains why regular NMN capsules perform so poorly compared to sublingual delivery of NMN. Sublingual delivery can bypass the stomach and liver to deliver NMN directly to the bloodstream.

The NMN Transporter – SLC12a8

This 2019 study found some NMN (but not NR) can be transported directly through the cell membrane and converted to NAD+ by the newly discovered SLC12a8 enzyme inside the small intestine.

Does the SLC12a8 Transporter mean all NMN capsules are as effective as Sublingual?

No. The quantity that is absorbed utilizing the Slc12a8 enzyme is not thought to be the the majority.

According to the authors:

“It is important to note that the discovery of an NMN transporter by no means diminishes the importance of uptake via dephosphorylation.”

There is hope the Slc12a8 Transporter can be useful.

“Dr. Imai’s lab already has identified small molecules that can stimulate production of the Slc12a8 NMN transporter, applied for patents, and licensed this technology to a company in Japan.”

Doubts about SLC12a8

There are a some Nicotinamide Riboside (NR) believers such as Chromadex’s chief science advisor, Dr. Brenner, who refuse to accept the research on the Slc12a8 NMN Transporter, but most accept the science.

However, there is huge variation between individuals and testing to quantify how much NMN is actually transported by SLC12a8, which has not yet been published. Researchers generally believe it is less than 10% with standard delivery methods.

The Solution – Stop Digestion of NMN by Bacteria in Stomach and Maximize Uptake by SLC12a8 Transporter in Small Intestine

To maximize uptake by the SLC12a8 enzyme, it is necessary to protect NMN from bacteria in the stomach.

AR-CAPS® Acid Resistant Enteric Capsules

Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.  This protects NMN from bacteria in the stomach, greatly increasing the quantity that is available for uptake by SLC12a8 enzymes in the small intestine.

Increasing Uptake by SLC12a8 NMN Transporter

Researchers like Dr. Sinclair are exploring methods to increase uptake by SLC12a8. Sodium is thought to be required, and making it more available may be key.

Sodium for Increased Uptake

Dr. Huzienga is a very well-known celebrity doctor – on advice from Dr. Sinclair, he uses Sodium Chloride to increase the uptake of NMN by SLC12a8. He also includes TMG to increase methylation and zinc to increase immunity.

Sodium Bicarbonate Instead of Sodium Chloride

While Dr. Huzienga has been using Sodium Chloride (table salt) in his NMN cocktail, our team has found Sodium Bicarbonate to be a better alternative for long term usage, as many people are trying to limit their salt intake.

 

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

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Why Us

ABOUT RENUE BY SCIENCE

As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and Facebook Group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price. Our contributions and constant objectives are:

  • Moving science forward
  • Driving prices down
  • Setting quality standards for assurance
  • Customer service equal to none

MOVING THE SCIENCE FORWARD

We constantly strive to improve the effectiveness of our products.  So we experiment a lot. We have made great strides improving the bioavailability of NMN and NAD+ products, and enjoy a great reputation among our fast growing customer base as a result.

Sublingual NMN Powder – In 2016 we realized sublingual delivery of NMN is a much more efficient delivery method, so we stopped selling capsules and engineered an NMN powder specifically designed for stability and absorption when taken sublingually. It was an immediate success, as most users can feel a rush of energy, far different than taking a capsule.

Sublingual NMN and NAD+ Tablets – After the success of our NMN Powder, we partnered with the leading pharmaceutical sublingual products formulator to create the first NMN tablets that work similar to the powder in a more convenient form.

NAD+ Nasal Spray – Delivery to the mucosal membranes to rapidly cross the blood brain barrier for a much different effect than sublingual delivery.

Liposomal NMN, NAD+ and NR - A liposome is a tiny bubble made out of the same material as a cell membrane, and are used to protect a supplement through the digestive system and deliver intact to the bloodstream. Liposomal Sublingual Gel™ (LSG) is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.

Renue Skin Care Products with Liposomal NAD+, NMN, and NR - Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)

Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state.

We pioneered ALL these advances in NAD+ products in 4 years, with many more coming in 2021, so stay tuned!

DRIVING THE PRICE DOWN

In 2015 when we began producing our own brand of NMN capsules, there were few manufacturers of raw material and the price was exorbitant.

We believed in the future of NMN, so made the leap and began selling at a break-even prices that were about 1/2 what others were charging, to help spur the markets.

Others were forced to follow our lead and lowered their price almost as low as ours.

We have continued with this model for 5 years now – constantly increasing the size of our orders, and seeing the manufacturing costs drop as more manufacturers see the growing market and learn how to produce the quality product we require.

We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers.

SETTING NEW STANDARDS FOR QUALITY

When we started selling NMN on Amazon in 2016, no-one was testing the purity of their product and displaying the proof.  Since it is an expensive product and there is no regulatory agency to insure quality, we decided to do so ourselves, and were the first to always post 3rd party test results. 

Not only do we test the raw material, but we post test reports for each batch of finished product, as it is simple for a company to just sent a sample off for testing, post that report, but not use any NMN in the bottle

A few have followed our lead now, but many others sell absolute garbage.  It is quite easy for a brand new company to pop up and slap a label on some worthless powder, buy some fake reviews on Amazon, and sell bottles to unwitting customers.  We had several tested and exposed some of the scammers, but with all the money they can make ripping people off, we couldn't battle all the new brands popping up every week, so left Amazon entirely in 2019.

Dr. Brad Stanfield has taken up the battle a bit and recently tested 21 different brands. Most had less than the advertised quantity of NMN per capsule, with several having NONE. You can see his review here.  Unfortunately, that too will have very little effect.

CUSTOMER SERVICE WITHOUT EQUAL

We never adopted the poor customer support standards of other online sellers and don’t outsource phone support to a 3rd party that has no idea what NMN is.

Call us and you will be surprised and the friendly, knowledgeable support.

Our Forum is a great resource for us and our customers to share information and feedback about what works and what doesn't.

We also sponsor trials where we give away free product to hundred of customers and learn more about how they like our products.

We learn from our customers.

One big difference between us and other supplement makers is, we actually talk to our customers!

That feedback has proven especially useful in the formulation of NAD+ products, and has helped us determine what works, without waiting years for the clinical research.

WHY RENUE BY SCIENCE

Whether you want to help support the company driving down prices and moving the science forward with the most effective products, or if you just want the best prices for the best quality NAD+ products, RENUE BY SCIENCE is the place.