NAD+ Reduces Oxidative Cell Damage

Oxidative stress and chronological aging can cause NAD+ breakdown in the skin. The NAD+ metabolic pathway has been implicated as a therapeutic target to promote cellular health. Recent studies have shown that enhancing NAD+ levels can reduce global oxidative cell damage, replenish total NAD+ stores and restore optimal skin cell function.

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Oleic Acid Enhances Skin Barrier Permeability

Free fatty acids (FFAs), specifically monounsaturated FFAs such as oleic acid, may disrupt skin barrier and act as permeability enhancers for other compounds present in plant oils. Dr. David Sinclair recently stated that he is using Oleic Acid, which stimulates the longevity-linked protein Sirt1 and maintains skin health.

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NAD+ Research for Skin Rejuvenation

Skin aging is driven by both external and internal factors such as sun exposure (UV), stress, environmental toxins and the natural mechanisms of aging occurring in all cells and tissues. Tissues with a high cellular turnover, such as the skin, require higher doses of NAD+ to counteract daily genomic threats, activate sirtuin proteins, and to rejuvenate skin.

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Apocynin Stimulates Growth of Collagen in Deepest Layers of Skin

Apocynin is the only known substance able to stimulate growth of the deepest layers of collagen (COL17A1) and repair damaged skin, leading scientists to say it may be possible to reverse our skin’s timeline at the cellular level. Apocynin is well known as a NADPH oxidase inhibitor and has powerful anti-inflammatory effects on the skin.

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Liposomes an Ideal Carrier system

Liposomes seem to be an almost ideal drug-carrier system. Micro-vesicle technology can act as a platform for the transdermal delivery of various micronutrients such as NAD+ and NMN through the skin using fluidizing liposomes incorporated within standard cosmetic bases. Liposomes circulate the blood the longest, leading to longer half-life of the substance.

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“Tissues with high cellular turnover, such as skin, require higher doses of NAD+ to counteract genomic insults.”

As you age, your skin is exposed to an array of environmental insults, which cause cellular dysfunction and over time it becomes difficult for the repair mechanisms to work efficiently. Your skin requires higher levels of NAD+ to combat damage and keep your skin in a youthful and healthy state. Aging is directly associated with lower NAD+ levels in the skin.

“With aging, both the epidermis and dermis undergo thinning and lose their regenerative capacity, which manifests as wrinkling, dryness, and mottling.”

UV radiation through sun exposure is associated with skin photo-aging, inflammation and oxidative damage. Photo-aged skin often has textural issues, wrinkles, uneven pigmentation and a leathery appearance. When the repair mechanisms can’t keep up, and NAD+ levels are low, it increases your susceptibility to further damage.

“NAD+ deficiency increases skin sensitivity to UV radiation, impairs DNA damage response, increases genomic instability.”

Delivery of NAD+ through transdermal liposomal serums and lotions, is an optimal way to safely raise levels of NAD+ in the skin. In dermal fibroblasts (cells within the dermis), nicotinamide protects against oxidative stress, glycolysis, oxidative phosphorylation and increases mitochondrial efficiency.

“Bioactive compounds targeting the mitochondria have proved effective against age-related as well as UV-induced skin damage, in addition to different skin diseases with mitochondrial involvement.”

The Renue Skincare line offers potent ingredients, a scientifically advanced formulation and a superior mode of delivery. Liposomes safely carry the active ingredients, which include our NAD+ Complex (NAD+ and NMN) and Apocynin, past the outer skin barrier and deep into your cells. The potent delivery system offers a deeper penetration of key ingredients into the skin’s surface to combat the most visible signs of aging and promote vibrant, youthful looking skin.


Role of Nicotinamide in Genomic Stability 
Mitochondria in Skin Health, Aging, and Disease
The Evolving Role of the NAD+/Nicotinamide Metabolome in Skin Homeostasis