RENUE BY SCIENCE introduces LIPO Caps™ the Gold Standard in supplement delivery systems that provides maximum nutrient absorption throughout the body and is clinically proven to enhance the bioavailability up to 6x more than liquid liposome formulations(1)

ABOUT LIPOSOMES

Liposomes encapsulate active ingredients in a phospholipid "bubble" to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. They are specialized delivery vehicles serving multiple roles in enhancing the capabilities of active ingredients. Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
  • Protects ingredients from digestion in stomach and intestines
  • Greatly increased circulation time in the bloodstream (not filtered out by liver)

BENEFITS OF LIPOSOMAL DELIVERY

The increased bioavailability of Liposomal Delivery make it:

MORE ECONOMICAL - MORE BANG FOR THE BUCK

Manufacturing liposomes does add cost to the finished product, which is why their usage has been more limited for vitamins and supplement as opposed to expensive pharmaceutical drugs.  However, a 2x increase in cost is vastly outweight by the 5-20x or greater increase in effectiveness of liposomal delivery. Many people realize liposomal delivery provides more "bang for the buck", but it is clear they also enable much greater effectiveness and safety, and should be used for all products with known bioavailability problems.

MORE EFFECTIVE - HIGHER LEVELS OF SATURATION IN TARGET TISSUES

Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you're taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely.  Liposomes deliver much higher quantities of the target molecules to the bloodstream.

SAFETY - MINIMIZES LIVER TOXICITY FROM EXCESSIVE DOSAGES

Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages.  The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished. - More about Liposomes

POWDERED LIPOSOME NAD+ PRODUCTS

Our LIPO CAPS tm powdered liposomes technology encapsulates nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It's a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body. This ensures maximum bioavailability and stability, protecting the bio-active ingredients against degradation. This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. (2) A peak particle size of less than 50 nm (nanometers) ensures the maximum bioavailability and stability. The advanced liposomes retain the core structure of the liposomal bilayer in its powder form, which stabilizes the active ingredient and ensures maximum bioefficiency, potency and absorption. We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity. More about Powdered Liposomes

WHY LIPOSOMAL DELIVERY IS CRITICAL

If not protected, NAD+ metabolites are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver.

TOO MUCH NAM

This can be a problem when users believe more is better and take excessive doses of standard NR or NMN capsules. Very little makes it intact through the digestive tract, liver, and bloodstream to reach the target tissue. The result is massive increases in NAM. For example, this study gave 300 mg/kg of NR to mice and found NAM is increased 40x, while NR is not increased and exists only at trace levels

“The minute amount of dual-labeled NAD observed in muscle indicates that direct utilization of NR by the muscle does occur. However, oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN."

WHAT HAPPENS IF NAM LEVELS ARE TOO HIGH

High levels of NAM can have many negative effects such as inhibiting Sirtuins (r), which is the opposite of what you are trying to accomplish by taking NAD+ boosters. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health.
"High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM." (r)
The body does respond to try and bring NAM levels down, by attaching a Methyl group to the NAM to form MeNAM, which is then excreted. (r) This can result in "methylation problems"  where there are insufficient methyl donors that are critical for other needs and promotes age related health problems. (r)

TMG MAY HELP RESTORE METHYL GROUPS WHEN NAM LEVELS ARE TOO HIGH

As a result, it is common practice now for those taking NMN or NR to take TMG or other methyl donors. (r) That is thought to help with the problem of excessive NAM buildup from taking high dosage NMN or NR capsules, but excess TMG can also lead to problems. (r)

LIPOSOMAL DELIVERY IS THE SOLUTION

A far better solution is to take a form of NMN or NR that protects the active ingredient from digestion to NAM. Sublingual delivery of NMN delivers up to 30% of NMN to the bloodstream, so much less is digested to NAM and depletion of methyl groups is much less of a problem. Liposomes are even better, as they can protect NAD+ metabolites from digestion and degradation in stomach, liver, and bloodstream. Liposomal delivery prevents your expensive NAD+ precursors from being digested to NAM, which is a waste of money, and can actually be bad for your health.
 

SMALL MOLECULES, BIG GAINS

LIPO NMR,NR, and NAD+ Complete are groundbreaking NAD+ boosters packed into easy to swallow, powdered liposomal capsules.

The first encapsulated oral delivery method to contain NMN, NAD+ and NR powdered liposomes, LIPO CAPS ™ protect cells against the effects of aging.

SUPERIOR CELLULAR UPTAKE

LIPO CAPS™ are a liposomal powder formulation that outperforms leading oral delivery methods by maximizing cellular uptake. This pioneering advancement is the first of its kind and offers concentrated delivery of NAD+, NMN and NR to cells and tissues for maximum bioavailability.

INCREASED RESIDENCE TIME IMPROVES POTENCY

Our proprietary nanoparticles are small enough to allow sustained blood circulation to restore your cells to what they were in youth.

Our natural liposomes share the same chemical makeup of our own cells, preventing rejection of vital nutrients and allowing effortless absorption.

SUPERCHARGED BIOAVAILABILITY

Like IV formulations, LIPO CAPS™ allows the body to readily absorb and utilize longevity-based nutrients, but they are significantly less expensive.

Liposmes bypass the dependency on intestinal absorption; thus, high circulating concentrations of NAD+, NMN and NR are achieved immediately.

ACTIVATED LIPOSOMES

Larger liposomes are recognized by the macrophages of the immune system as foreign invaders, and cleared from the blood more rapidly. 2  Our activated liposomes are less than 50 nanometers made from organic phospholipids, the same components of our own cell membranes.

Our proprietary system activates, stabilizes and packages NAD+, NMN and NR into a tiny bubble that is bioidentical to your cells, so is not filtered out by the liver and is absorbed easily.

“We’re mimicking how the body absorbs nutrients. These liposomal particles are as small as 50 nanometers across and overcome all challenges of bioavailability,” says Bryan Nettles, Founder and CEO

POWDERED LIPO™ BENEFITS

  • Maximizes nutrient absorption rate
  • Require smaller doses for efficacy with minimal unintended byproducts
  • Targeted delivery to cells and tissues
  • Increased systemic circulation time
  • Increased formulation stability
  • Extremely cost effective vs standard capsules with poor bioavailability

OUR MANUFACTURING PROCESS

Every step of our certified liposomal manufacturing process is carefully documented and tested, exceeding cGMP standards.

    1. Ingredients are tested for purity, identity and strength
    2. Supplements are weighed and mixed precisely
    3. Purified water is used in all processes
    4. Actives are compounded with natural phospholipids in our proprietary processto form the next generation of liposomes
    5. Liposomes are flavored using 100% pure ingredients found in nature
    6. Product is packaged and tested again for purity, identity and strength