Longevity research has evolvedย from its early focus on merely extending lifespan to a broader, more impactful goal: extending healthspan โ the period of life spent in good health. While lifespan measures the number of years lived, healthspan emphasizes quality, encompassing physical, mental, and emotional health (Box 1). Recognizing this distinction has propelled the scientific community to concentrate on interventions that do more than simply add years to the end of life; they aim to add life to years, effectively prolonging the healthy phase of midlife and delaying the debility and functional decline observed in the final 10-20 years of a personโs life.
This shift has catalyzed the development of personalized health interventions, which leverage advancements in genetic testing, biomarker analysis, microbiome science, wearable technologies, and novel supplements to tailor health strategies to individual needs. Unlike one-size-fits-all approaches, personalized methods recognize the inherent variability in human biology and behavior. For instance, factors such as genetic predispositions, lifestyle, and environmental exposures can significantly impact how each person responds to diet, exercise, and supplementation strategies.
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