Sublingual

NMN (Nicotinamide Mononucleotide) Pure Powder

Name: NMN (Nicotinamide Mononucleotide) Pure Powder
Brand: Renue Store
SKU: 850055685192
Price: 64.95 USD
Availability: InStock
Rating: 4.5 (265 reviews)

Fast dissolve NAD+ boosting powder

$64.95 USD

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Pure Crystalline NMN Powder is designed for absorption under the tongue for superior bioavailability.

Sublingual

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NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

What is NMN?

NMN (Nicotinamide Mononucleotide) is a naturally occurring molecule found in all living cells. It serves as a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme that fuels essential biological processes. Without adequate NAD+, your cells can’t function efficiently, which can trigger loss of function from the cellular level all the way up to affecting your entire body.

The Critical Roles of NAD+

NAD+ is essential for several key processes that maintain cellular health and longevity:

Energy Metabolism: NAD+ facilitates the conversion of nutrients into energy (ATP) through cellular respiration in the mitochondria. It participates in the electron transport chain, a process that powers nearly every function in the body.

DNA Repair: NAD+ supports the function of enzymes called PARPs (Poly (ADP-ribose) polymerases), which repair DNA damage caused by oxidative stress, radiation, and environmental toxins. Maintaining DNA integrity is essential for healthy aging and maintaining function.

Sirtuin Activation: NAD+ is a co-substrate for sirtuins, a family of enzymes that regulate cellular health, metabolism, and longevity. Sirtuins play a role in processes like inflammation control, mitochondrial biogenesis, and genomic stability.

Mitochondrial Health: NAD+ is required for optimal mitochondrial function. Mitochondria are the powerhouses of cells, and their efficiency determines your energy levels and resilience against the loss of function commonly seen in aging. NAD+ helps mitochondria generate energy and reduce oxidative damage.

Why Do NAD+ Levels Decline with Age?

As we age, NAD+ levels can decline by up to 50% by middle age and continue to decrease thereafter. This decline is driven by several factors:

Increased NAD+ Consumption: Aging, stress, and inflammation increase the activity of enzymes like CD38 and PARPs, which consume NAD+ during DNA repair and immune responses [1].

Reduced NAD+ Production: The efficiency of the Salvage Pathway, which recycles NAD+ precursors like NMN and NR (Nicotinamide Riboside), diminishes over time [2].

Oxidative Stress and Inflammation: Chronic oxidative stress accelerates NAD+ depletion, impacting cellular repair and energy production [3].

This decline in NAD+ levels can contribute to a range of age-related issues, including:

Fatigue and Decreased Energy Levels
Impaired Cognitive Function
Weakened Immune System
Reduced DNA Repair Capacity
Slowed Metabolism

How NMN Replenishes NAD+

Replenishing your NAD+ stores with NMN offers a way to counteract the age-related decline in NAD+. NMN is efficiently absorbed and converted into NAD+ through the Salvage Pathway, the body’s primary method for maintaining NAD+ levels. Here’s how NMN works:

Uptake by Cells: NMN is transported directly into cells via the Slc12a8 transporter, where it bypasses some of the slower steps required by other NAD+ precursors [4].

Conversion to NAD+: Once inside the cell, NMN is converted into NAD+ by the enzyme NMNAT (Nicotinamide Mononucleotide Adenylyltransferase) [5].

Supports Cellular Function: Elevated NAD+ levels promote efficient energy production, DNA repair, and activation of sirtuins and PARPs, enhancing overall cellular resilience and function [6].

Why NMN is Essential for Optimal Cellular Health

Consistently taking NMN provides your body with the raw material it needs to produce NAD+ and maintain optimal cellular function.

By boosting NAD+ levels, NMN helps:

Sustain Energy Levels by protecting mitochondrial function.
Support DNA Repair to maintain genomic stability.
Activate Longevity Pathways through sirtuin activity.

Incorporating NMN into your daily routine offers a science-backed
approach to healthy aging, helping you stay energized, resilient, and
vibrant as you grow older.

NMN (Nicotinamide Mononucleotide) Pure Powder

Protects Energy Metabolism

NMN boosts NAD+ levels, supporting efficient cellular energy production. Studies show that NMN supplementation can improve mitochondrial function, reducing age-related fatigue and enhancing physical
endurance [5].

Supports Brain Health

Maintaining NAD+ levels is vital for brain health.
NMN may promote neuroplasticity, and support neuronal repair by supporting
mitochondrial health in brain cells [6].

Promotes DNA Repair and Cellular Health

NAD+ is necessary for activating DNA repair enzymes like
PARPs. By replenishing NAD+, NMN helps your cells repair damage caused by
oxidative stress and aging [3].

Protects Cardiovascular Function

Research indicates that NMN can protect normal blood flow and endothelial function by replenishing NAD+ levels [7].

Supports Metabolic Flexibility

NMN promotes healthy metabolism by supporting balanced
glucose levels. This can help protect against metabolic decline associated with
aging [8].

Why NMN is Essential for Healthy Aging

Aging is a process with many moving pieces and is influenced by cumulative damage at the cellular level. This damage includes oxidative stress, DNA damage, and chronic inflammation, all of which increase the
demand for NAD+ [1].

This imbalance sets the stage for a range of age-related challenges.

Bridging the NAD+ Gap with NMN

The age-related decline in NAD+ levels creates a vicious cycle of cellular dysfunction. Without adequate NAD+, cells struggle to repair damage, produce energy, and maintain overall health.

This can lead to:

Persistent fatigue
Poor memory formation and recall
Frequent illness
Weight gain and metabolic slowdown

NMN provides a scientifically supported way to restore NAD+ levels and break this cycle. By supplying your cells with the raw
material needed to produce NAD+, NMN helps:

Rejuvenate Mitochondria: Promote energy production and fight fatigue.

Repair DNA: Support cellular maintenance and genomic integrity.

Activate Longevity Pathways: Trigger sirtuin activity for healthier aging.

Boost Immune Resilience: Support your body’s defenses against illness.

Optimize Metabolic Health: Promote insulin sensitivity and energy metabolism.

Pure and Effective – Why Choose Our NMN Powder?

High Purity: Our NMN powder is third-party tested for purity and potency to ensure you receive exactly what you’re expecting – NMN
powder and nothing else.

Fast Absorption: The pure powder form allows for rapid uptake and efficient conversion to NAD+.

Convenient: Just place a scoop of powder under your tongue and allow it to dissolve. Easy!

We are committed to delivering NMN that is scientifically validated and formulated to help you thrive, not just survive.

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.