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Remember when you could stay up until 2 AM and still crush it the next day? When hangovers lasted hours, not days? When you could stay focused without that afternoon espresso?
The resilience and energy of youth comes from NADβΊ.
By age 50, you have half the NADβΊ you had at 20. As you celebrate more birthdays, that decline continues further.ΒΉ
You don't have to accept this as "normal aging" when you look at it as a solvable problem.
Think of NADβΊ (nicotinamide adenine dinucleotide) as your cellular fuel and repair crew rolled into one.
Every cell in your body uses NADβΊ to:
When NADβΊ is high, these processes hum along. You feel energetic, recover quickly, think clearly.
When NADβΊ drops? Everything slows down. Energy tanks. Recovery drags. Brain fog sets in. You age faster.
Beyond feeling tired, low NADβΊ creates a cascade of cellular dysfunction:
Your brain uses ~20% of your bodyβs resting energy,6 and neurons depend on NADβΊ to fuel the ATP that keeps them firing. As NADβΊ falls with age or stress, your brainβs energy efficiency declines, contributing to mental fatigue and brain fog.
Here's what most NADβΊ supplements don't tell you:
Taking NMN or NR alone is like filling a bucket with holes in it. Sure, you're adding NADβΊ to your system by taking a precursor, but you're not addressing:
This is why people take NMN for a month, feel great, then plateau. They're fighting a losing battle.
More NMN alone won't solve the problem. The right answer is a smarter strategy.
After years of analyzing the research, we've aligned with a systems-level approach to address four main pathways to support healthy NAD+ levels throughout the entire body. This systems-level approach is described elegantly by Nichola Conlon and Dianne Ford in a recent study on NAD+ restoration.
Every Renue By Science formula helps you maximize NAD+ through one of these pathways.
Why This Works: Different tissues prefer different routes.ΒΉβ΅ Your liver likes one pathway, your muscles another. By providing multiple options, cells can choose the fastest route available, no bottlenecks.
Research Shows: Steady NAD+ levels throughout the day, supporting consistent energy and cellular function.15
It's like having a Ferrari with a fuel leak. It doesn't matter how much gas you add, you're going to slow down and stall out.
Why This Works: Studies show quercetin and apigenin can downshift CD38 activity.Β²Β³ That means the NADβΊ you make actually stays available for useful work.
Research Shows: Supplements that "stopped working" suddenly start to work again.Β
Why This Works: When mitochondria run clean, they need less NADβΊ to make the same amount of energy. AMPK activation also triggers the production of new, more efficient mitochondria.Β³ΒΉ
Research Shows: Better endurance, faster recovery, improved metabolic markers.
Why This Works: Removing damaged proteins and mitochondria at night means less NADβΊ needed for emergency repairs during the day. Clean cells are efficient cells.
Research Shows: Waking up refreshed instead of briefly just "less tired."
BOOST provides NAD+ precursors through multiple biosynthetic routes: salvage, Preiss-Handler, and NR kinase pathways. This increases substrate availability for NAD+ production.ΒΉβ΅
PROTECT inhibits CD38 and reduces inflammation-driven NAD+ consumption. CD38 activity can consume 100x more NAD+ than other enzymes, so blocking it preserves your NAD+ pool.Β³βΈ
OPTIMIZE improves mitochondrial efficiency through SIRT1 activation and AMPK signaling. More efficient mitochondria require less NAD+ to produce the same amount of ATP.Β²βΆ, Β³ΒΉ
REGENERATE activates autophagy and cellular cleanup during sleep, reducing the accumulated damage that creates NAD+ demand for repairs.Β³Β², Β³β΅
When combined, these pathways create a positive feedback loop:
The result: NAD+ levels rise and stabilize rather than experiencing the typical single-supplement plateau. Research shows multi-pathway interventions achieve better outcomes than single precursor supplementation alone.
Understanding the four pathways changes how you think about energy and aging. You now see why that afternoon crash happens, why recovery takes longer than it used to, and why some supplements work initially then fade.
More importantly, you understand there's a systematic way forward.
Some people start with just one pathway, usually BOOST for quick energy improvements or PROTECT if they're already taking supplements that seem less effective than before. Others prefer addressing multiple pathways together for synergistic benefits.
What most people find: Starting somewhere, even imperfectly, teaches you what your body responds to. The first positive change usually happens within the first two weeks. That initial improvement often clarifies what to adjust next.
The research provides the map. Your experience becomes the compass.
You can, but you're leaving 75% of the benefits on the table. It's like having a sports car but only using first gear.
Most people notice energy improvements in 3-7 days. Deeper benefits (recovery, cognitive, metabolic) typically emerge by week 3-4.
Every ingredient has extensive safety data in human and animal models. Our dosing strategies reflect the standards set by researchers for safe use.
It would be if we were claiming one pill fixes everything. We're not. This is about systematically addressing multiple failure points in a well-studied biological system. The research is published in Science, Nature, Cell, established scientific journals, not wellness blogs.
Medical education focuses on disease treatment, not optimization. NADβΊ biology has exploded in the last decade. Most physicians trained before this research emerged, and even if it was covered, most doctors arenβt focused on longevity as a subspecialty. Additionally, you can't patent NADβΊ or its precursors since theyβre natural molecules and are made inside the body, so there's limited pharmaceutical interest in education for funding reasons.
Valid concern. Raw NADβΊ precursors without supporting pathways can have poor utilization. That's exactly why the four-pathway approach exists: to ensure what you take gets used, not excreted. The PROTECT pathway specifically addresses this by reducing wasteful consumption.
At physiological doses, side effects are minimal. Some people experience initial sleep changes (as circadian rhythms adjust), or digestive changes (as the microbiome adapts). These typically resolve within days. Start low, increase gradually. Always check for ingredient interactions if you're on prescriptions or are under the care of a physician.
At physiological doses, side effects are minimal. Some people experience initial sleep changes (as circadian rhythms adjust), or digestive changes (as the microbiome adapts). These typically resolve within days. Start low, increase gradually. Always check for ingredient interactions if you're on prescriptions or are under the care of a physician.
While everyone over 30 has declining NADβΊ, certain people see more dramatic improvements:
Every day you wait, NADβΊ levels drop a little more. CD38 increases. Mitochondria get less efficient. The gap between how you feel and how you could feel widens.
Or you can take control. Use all four pathways. Restore your NADβΊ systematically, scientifically.
