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Is it just aging, or are your NAD+ pathways slowing down?
When one pathway stalls, your energy suffers.
NAD+ is essential for energy, repair, and resilience. As we age, NAD+ synthesis pathways slow down, leading to a dramatic drop in cellular energy. By age 50, we have half of what we did when we were younger. Factors like poor diet, sedentary lifestyles, illness, and environmental toxins deplete NAD+ even faster.
Our scientifically designed multi-pathway formulas restore NAD+ where your biology needs it most.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. If you ran out, your body would stop working β within seconds. It fuels the enzymes responsible for DNA repair, energy production, cellular stress response, and gene expression. Without it, your cells canβt function, adapt, or repair themselves.
As you age, your NAD+ levels drop up to 50% by age 50, and even more in tissues under metabolic stress. This decline isnβt just a side effect of aging: itβs a driver of it.
What it targets: Low cellular NADβΊ.
How it works: Supplies precursors that feed the bodyβs NADβΊ-making routes so more raw NADβΊ is available when cells need it.
Includes: NMN, NR, Trigonelline, and direct NADβΊ.
Why it matters: A higher, steadier supply supports daytime energy metabolism and cell maintenance.
What it targets: Unnecessary NADβΊ drain from inflammatory signaling and overactive NADβΊ-consuming enzymes.
How it works: Senolytic and polyphenol support helps lower senescent-cell burden and modulates enzymes like CD38 and PARPs, conserving NADβΊ for useful work.
Includes: Fisetin, Quercetin, Apigenin, Hesperidin.
Why it matters: Less waste means more NADβΊ available for repair, resilience, and metabolism.
What it targets: Sluggish mitochondrial output and metabolic inflexibility.
How it works: Activates cellular switches (AMPK, SIRT1/3) and supports electron transport so cells convert fuel to ATP more cleanly.
Includes: Resveratrol, Berberine, EGCG, CoQ10, CaAKG.
Why it matters: Better utilization turns a steady NADβΊ pool into steady energy and recovery.
What it targets: Buildup of worn-out components and poor overnight recovery.
How it works: Encourages autophagy/mitophagy and calm sleep architecture so cells can recycle and rebuild while you rest.
Includes: Spermidine, GABA, 5-HTP, Apigenin.
Why it matters: Cleaning and rebuilding at night sets up stronger NADβΊ dynamics the next day.
The cellular energy crisis.
Why Modern Life Destroys NAD+:
- Blue light exposure disrupts circadian .NAD+.
- Processed foods are inflammatory and increase CD38.
- Chronic stress means constant repair demand.
- Sedentary lifestyle damages mitochondrial function.
- Poor sleep shortens or eliminates nightly recovery window.
- Alcohol detoxification depletes NAD+ stores.
The mismatch: Your body expects feast/famine cycles, sunrise/sunset rhythms, and physical demands. Instead, it gets constant food, artificial light, and Netflix.
The solution: Since we can't live like our ancestors, we need to supplement what modern life depletes.
The functional cost of NAD+ loss.
YOU MAY NOT SEE NAD+ LEVELS DECLINE, BUT YOU CAN FEEL THE CONSEQUENCES.
Fatigue and poor recovery
Brain fog and forgetfulness
Weaker immunity
Slower repair and regeneration
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
NAD+ powers cellular energy production and overnight recovery. Low NAD+ means workouts drain you for days and sleep doesn't restore you.
Evidence for the four-pathway approach.
We analyzed hundreds studies and found:
- Multiple precursors work better:Different cells prefer different NAD+ builders.
- CD38 is the hidden problem: It increases with age, eating your NAD+.
- Mitochondria need support: Better efficiency = less NAD+ waste.
- Sleep is when repair happens: Poor sleep = higher NAD+ demand.
Key Studies:
- NMN improves insulin sensitivity (Science, 2021)
- Quercetin inhibits CD38 (Diabetes, 2013)
- Resveratrol enhances mitochondria (Cell Metabolism, 2011)
- Spermidine activates autophagy (Nature Medicine, 2016)
Taking NMN or NR alone is like filling a bucket with holes in it. Sure, you're adding NADβΊ to your system by taking a precursor, but you're not addressing the enzymes like CD38 literally eating your NADβΊ faster than you can make it, the inflammation driving those enzymes higher, the inefficient mitochondria wasting what NADβΊ you do have, or the cellular damage creating constant NADβΊ demand.
Individual responses vary widely to NAD precursor supplementation.
While some people feel great from taking NMN, others may feel a small difference or nothing at all. This is why the 4 pathway approach works: we account for individual variation in precursor response so you can experience the benefits of boosting your NAD+ levels without having to guess which form will work best for you.
This graph shows the NMN Group (red triangles) overall had higher NAD+ levels compared to the Placebo Group (blue circles) at weeks 4 and 12.
However, individual responses varied (red triangles show a range from 25 to 90 Β΅M).
Let customers speak for us
Been using it for well over a year now.Tests have shown an increase in my testosterone levels.
I love this product and I mix it with a little bit
of olive oil. Only 7 days into this, and looking forward to the benefits.
within a half an hour I could tell an increase in energy and clarity. Iβve slowly increased my dose. I take them first thing every morning.
on average, how long to see any benefits
My partner LOVES this nasal spray; gives him a boost. I do not use it as I'm very sensitive to the spray and do not like the way I feel on it. I use the NMN Powder instead in the morning.
When I initially tried your product, my son gave it to me as a gift. I really helps my breathing and stamina when I take it before workouts. I'm 74 years old, I workout 6 days out of the week for 3 hours per day. I have for years. But for some reason, I was starting to really drag. Your product helped put me back on track. I'm back to my old self.
Seems to work well and is often revommended.
Great product, slightly less expensive than a leading competitor, Iβm in! Love it !
I love how quickly it dissolved, had no taste and the health benefits. Worth every penny
I've been taking the NMN powder for several years now and have not had any health issues. I believe it is helping my system as my test results have been good.
As pure and high-quality as they can make it
My option was to take your product or statin drugs. I chose cardio max because it is closer to what was provided in creation.
Great product it helps me sleep. I have noticed significant improvement in my eye sight since I began taking it 1 year ago
Myth 1: "More is Better"
Reality: Pathways saturate. 1000mg isn't better than 500mg if your salvage pathway is full.
Myth 2: "NAD+ Can't Be Absorbed Orally"
Reality: Precursors like NMN and NR are absorbed. New liposomal tech enables direct NAD+ absorption.
Myth 3: "IV NAD+ is Superior"
Reality: IVs create spikes that fade in days. Daily oral creates sustained levels. (Plus IVs cost $500+ per session)
Myth 4: "Young People Don't Need It"
Reality: NAD+ starts declining at 30. Prevention is easier than restoration.
Myth 5: "It's Just Expensive Vitamin B3"
Reality: While related, NMN and NR use different pathways than niacin and don't cause flushing.
NAD+ myths debunked.
What the Internet Gets Wrong.
Longevity foundations.
WE COMBINE INGREDIENTS PROVEN TO IMPACT YOUR NADβΊ LEVELS THROUGH FOUR MAJOR PATHWAYS.
LIPO NADβΊ Complete
Senolytique
Energizer AM
Restore PM
The science behind NAD+.
How to choose the best NMN for you.
Updated NMN Human Trials
The future of NADβΊ research.
