120 Capsules Allergen-Free

900 mg Each of Pure TMG

Serving Size 2 Capsules

Combination Product

TMG Methylation Essentials

Name: TMG Methylation Essentials, 120 Ct.
Brand: Renue Store
SKU: 850055685062
Price: 27.95 USD
Availability: InStock

$27.95 USD

Shipping calculated at checkout.

TMG Methylation Essentials combines a crucial set of nutrients to support optimal methylation.† The formulation is crafted to enable peak cellular function, DNA protection, and healthy aging.†

Product variants

120 Capsules Allergen-Free

900 mg Each of Pure TMG

Serving Size 2 Capsules

Combination Product

Details

Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.†

Methylation is a chemical process that happens in every cell of your body and it’s essential for:

Making energy
Repairing cells
Regulating gene expression

Each capsule contains

One Serving of 2 Capsules Contains ▸900 mg TMG ▸12 mg Zinc ▸ 1000 mcg Folate ▸ 30 mcg B12 ▸ 5.1 mcg B6

Nutrients to Support Methylation

TMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.†

“The changes in DNA methylation across a lifespan is a hallmark of aging.” (1)

Aging and Methylation Issues

Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.†

“Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.” ⑵

Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†

NAD* Precursors and Methylation Pathways

When taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.†

“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4)

It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD⁺ precursors are often supplemented with TMG and other compounds that support methylation pathways.†

Acid Resistant Enteric Capsules

Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.

View full details

Trimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.†

Methylation is a chemical process that happens in every cell of your body and it’s essential for:

Making energy
Repairing cells
Regulating gene expression

Nutrients to Support Methylation

“The changes in DNA methylation across a lifespan is a hallmark of aging.” (1)

Aging and Methylation Issues

Research indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.†

“Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.” ⑵

Methylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†

NAD+ Precursors and Methylation Pathways

“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (4)

It has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (5) This is why NAD+ precursors are often supplemented with TMG and other compounds that support methylation pathways.†

Acid Resistant Enteric Capsules

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification Gold Standard Testing Certificate of Analysis

Frequently Asked Questions

TMG FAQ

How does TMG help with methylation support?

In certain cases, taking NAD⁺ boosting supplements can deplete levels of methyl groups in the body. TMG is one of the most important ways to restore methyl groups because as the name implies, it has three methyl groups to donate As NAD⁺ gets used, it is broken down into Nicotinamide (NAM).

Learn more on the Bioavailability Page here.

Is it necessary to take TMG with NMN?

There is no research that says normal dosages (less that 1,000mg) of NMN or NR deplete methyls and require TMG.

However, it is possible and TMG may help some people.

Dr. Sinclair started recommending taking TMG just in case, as it is very safe and may help.

We now sell TMG here.