90 Capsules Allergen-Free

75 mg Each LIPO Apigenin

Serving size 1 capsule

Apigenin (Liposomal)

Name: Apigenin (Liposomal) 90 Ct.
Brand: Renue Store
SKU: 656165996261
Price: 49.95 USD
Availability: InStock

Polyphenol protection

$49.95 USD

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LIPO Apigenin features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect it from digestive enzymes and carry it into the bloodstream for targeted systemic delivery.

LIPO Apigenin is also available in our combination product, Restore PM.

Product variants

90 Capsules Allergen-Free

75 mg Each LIPO Apigenin

Serving size 1 capsule

Details

Apigenin is a naturally-occurring bioactive plant polyphenol known to protect cells from oxidative stress. Apigenin seeks out aging and potentially harmful cells, fostering a youthful cellular environment, while mitigating toxicity to neighboring cells.

Liposomal Delivery

LIPO Apigenin uses a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.

Senescent Cells Increase CD38 and Decrease NAD⁺ Levels

As you age, you accumulate senescent or “zombie” cells, cells that have reached their limit of cell division and would normally be swept away and replaced by younger cells. Instead, these cells hang around and begin to secrete toxins called SASP factors which increase systemic inflammation.

The rising levels of inflammation cause an increase in an enzyme called CD38, a big consumer of NAD⁺, causing systemic NAD⁺ levels to drop.

“Our data suggest a link between cellular senescence and NAD⁺ decline in which SASP-mediated upregulation of CD38 can disrupt cellular NAD⁺ homeostasis.” (1)

Fighting Declining Levels of NAD⁺ with Apigenin

Apigenin prevents excessive loss of NAD⁺ by reducing the amount of circulating CD38, allowing NAD⁺ stores to remain at higher, more youthful levels.

We showed that the activity of CD38, but not PARP, increases in several tissues during the aging process, and that genetic ablation of CD38 protects against age-related NAD⁺ decline and, mitochondrial dysfunction.” (2)

Inhibition of CD38 Increases Lifespan and Healthspan in Mice

Studies have found that lowering CD38 levels (using a CD38 inhibitor called 78c) not only increased NAD⁺ levels but also improved mitochondrial function and endurance performance.

“Aged mice (2 years old) had lower tissue NAD⁺ levels, and worse glucose tolerance compared with younger mice. 78c promoted a significant increase in NAD⁺ levels in tissues of aged mice.” (3)

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Polyphenol to Promote Healthy Sleep

Apigenin is a naturally-occurring bioactive plant polyphenol known to protect cells from oxidative stress.

Apigenin seeks out aging and potentially harmful cells, fostering a youthful cellular environment, while mitigating toxicity to neighboring cells.

Certifications

Supported by Science

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Strength and Purity Certification Gold Standard Testing Certificate of Analysis

Frequently Asked Questions

LIPO APIGENIN

Can you take too much Apigenin & suppress CD38 too much?

CD38 is increased locally in response to inflammation.

Excessive inflammation with age results in CD38 dramatically increasing, which utilizes NAD⁺.

Theoretically, too much suppression of CD38 might interfere too much with the body’s response to inflammation.

CD38 is not easily measured. If CD38 was decreased so much it is a problem, it seems likely inflammation would show increase. HsCRP would be a good indicator.

LIPOSOMAL DELIVERY

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.