Which NAD+ Precursor Is Best?

NAD+


This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN


This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR


This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline


Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

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4.1
Rated 4.1 out of 5 stars
Based on 21 reviews
76%would recommend this product
21 reviews
  • P
    Peggy
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    5 Stars

    Amazing product. I’ve been taking it for over a year. Definitely feel a difference when I don’t take it .

  • LN
    Laine N.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Love it.

    I love it. Been about a week. I feel so much better in the morning after taking. It has reversed my neuropathy in my feet. Will be ordering more soon.

  • M
    Miguel
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    5 Stars

    Good

  • MJ
    Milton J.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    6 months ago
    I just switched from NMN to NR

    I just switched from NMN to NR. I've been taking NMN for several years, but NR is touted to be a better choice. I hope my choice to switch was wise

  • R
    Ralph
    I recommend this product
    Rated 5 out of 5 stars
    8 months ago
    5 Stars

    Great