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Combination Product

Total NAD+ Restoration Protocol

Name: Total NAD+ Restoration Protocol
Brand: Renue By Science
SKU: 850055685260
Price: 207.0 USD
Availability: InStock
Rating: 4.56 (27 reviews)

Comprehensive defense against the damage of aging

$207.00 USD

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The Total NAD+ Restoration Protocol is designed as comprehensive defense against the damage of aging.

Including a liposomal blend of NAD+ precursors, senolytics, CD38 inhibitors, and ingredients to promote resilience and rest, this research-backed protocol is the most advanced answer to NAD+ decline and loss of youthful function.†

Combination Product

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NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

Complete NAD+ Support

The Total NAD+ Restoration Protocol is designed to enhance NAD+ production, protect against NAD+ loss through CD38 enzymes, senescent cell accumulation, and inflammation, as well as support energy production, stress resilience, DNA integrity, and deep sleep.

The Total NAD+ Restoration Protocol is a scientifically designed kit that supports youthful NAD+ levels, a coenzyme involved in cellular metabolism, DNA repair, and signaling pathways.By targeting multiple mechanisms that contribute to NAD+ decline, such as CD38 enzyme activity, senescent cell accumulation, and inflammation, this protocol supports energy production, stress resilience, genomic stability, and circadian rhythm regulation.The ingredients used in these formulas are poorly absorbed on their own, with only 5-10% bioavailability. By using liposomal forms of these ingredients, the bioavailability is increased to over 90%.

Lipo NAD+ Complete is a comprehensive liposomal formulation that incorporates essential NAD+ precursors to support cellular NAD+ biosynthesis.

NAD+: This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN: This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR: This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline: Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Senolytique is designed to selectively eliminate senescent cells, which accumulate with age, secrete pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP), and contribute to chronic inflammation and tissue dysfunction. The accumulation of senescent cells has been tied to various age-related pathologies, including cardiovascular disease, neurodegeneration, and metabolic disorders.

Quercetin and Fisetin: These flavonoids exhibit potent senolytic properties by inducing apoptosis in senescent cells through the inhibition of pro-survival pathways. Quercetin has been shown to inhibit the PI3K/AKT pathway, which is overactivated in senescent cells and contributes to their resistance to apoptosis. Fisetin, on the other hand, downregulates the expression of anti-apoptotic proteins, such as BCL-2 and BCL-XL, thereby sensitizing senescent cells to apoptotic stimuli. Moreover, both quercetin and fisetin have been reported to attenuate the SASP by modulating the NF-κB and p38 MAPK signaling pathways, which are key regulators of pro-inflammatory gene expression.

Spermidine: This polyamine induces autophagy, a cellular process that facilitates the degradation of damaged proteins and organelles, thereby promoting cellular renewal and longevity. Spermidine activates the autophagy-initiating kinase, ULK1, and inhibits the mTORC1 complex, a negative regulator of autophagy. Furthermore, spermidine has been shown to enhance the expression of key autophagy-related genes, such as ATG5 and ATG7, through epigenetic modifications. By promoting the autophagic clearance of senescent cells and their associated SASP factors, spermidine contributes to the maintenance of tissue homeostasis and the attenuation of age-related functional decline.

Energizer AM focuses on optimizing mitochondrial function and cellular energy production to combat fatigue and support stable all-day energy. Mitochondrial dysfunction is a hallmark of aging and is associated with reduced ATP synthesis, increased oxidative stress, and impaired metabolic flexibility.

Hesperidin: This bioflavonoid supports mitochondrial respiration and ATP synthesis by modulating the activity of key enzymes involved in the electron transport chain and citric acid cycle. Hesperidin has been shown to increase the expression and activity of citrate synthase, a rate-limiting enzyme in the citric acid cycle, thereby promoting efficient substrate utilization and energy production. Additionally, hesperidin scavenges reactive oxygen species (ROS) and upregulates antioxidant enzymes, such as superoxide dismutase and catalase, protecting mitochondria from oxidative damage.

Trans-Resveratrol and Epigallocatechin Gallate (EGCG): These polyphenols activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate diverse cellular processes, including mitochondrial biogenesis, antioxidant defenses, and metabolic pathways. Resveratrol and EGCG have been shown to activate SIRT1 by increasing NAD+ levels and promoting the deacetylation of PGC-1α, a master regulator of mitochondrial biogenesis. Furthermore, these polyphenols modulate the activity of AMP-activated protein kinase (AMPK), a key energy sensor that stimulates mitochondrial function and fatty acid oxidation.

Restore PM supports deep, restorative sleep cycles and built-in restorative processes by modulating neurotransmitter signaling and protecting against oxidative stress. Sleep disturbances and chronic stress are associated with impaired cognitive function, metabolic dysregulation, and accelerated aging.

Gamma-Aminobutyric Acid (GABA) and 5-Hydroxytryptophan (5-HTP): These neurotransmitter precursors promote relaxation and enhance sleep quality by modulating the activity of GABA and serotonin receptors, respectively. GABA is the primary inhibitory neurotransmitter in the central nervous system, and its signaling reduces neuronal excitability and promotes sleep onset. 5-HTP, on the other hand, is a precursor to serotonin, a neurotransmitter involved in regulating mood, appetite, and sleep-wake cycles. Supplementation with GABA and 5-HTP has been shown to improve sleep latency, duration, and efficiency, as well as reduce feelings of anxiety and stress-related symptoms.

Apigenin: This flavonoid exhibits anxiolytic and sedative properties by interacting with GABA receptors and promoting neuroprotection through its anti-inflammatory effects. Apigenin has been shown to bind to sites on GABA-A receptors, enhancing the inhibitory effects of GABA and promoting relaxation. Moreover, apigenin modulates neuroinflammation by inhibiting the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, and reducing the activation of microglial cells, which are key mediators of neuroinflammation.

Glutathione and Melatonin: These potent antioxidants protect neural cells from oxidative damage, support detoxification processes, and regulate the circadian rhythm, thereby promoting restorative sleep. Glutathione is the master antioxidant in the body, neutralizing ROS, detoxifying xenobiotics, and maintaining redox homeostasis. Melatonin, a hormone primarily secreted by the pineal gland, regulates the sleep-wake cycle and exhibits strong antioxidant properties. Melatonin has been shown to scavenge free radicals, enhance the activity of antioxidant enzymes, and protect mitochondria from oxidative stress. Furthermore, melatonin modulates the expression of clock genes, maintaining circadian rhythms and promoting healthy sleep patterns.

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Enhanced Bioavailability

Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.

Total NAD+ Restoration Protocol

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

I take these every day

I take these every day. I think it helps? But the cost is pretty steep!

Fantastic supplement stack!

Fantastic supplement stack--keeps me going!

Not really sure

I bought a 2-month supply. I'm 3 weeks into it and they asked me to review. As of right now I'm not certain. I think I feel the effects subtly I don't know. I'm just hoping that it's working lol

No noticeable results, disappointing experience

I had high hopes for the Total NAD+ Restoration Protocol, but unfortunately it didn’t deliver. After following the instructions closely for several weeks, I didn’t notice any improvement in energy, focus, or overall well-being. For the price, I expected something more effective.

I believe

I believe, based on a lot of careful research, that ‘Renue by Science’ products are at the ‘cutting edge’ of longevity supplements. I feel healthy and energized by taking them.