Combination Product
Combination Product
NAD+:ย This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
NMN:ย This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
NR:ย This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
Trigonelline:ย Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
Quercetin and Fisetin:ย These flavonoids exhibit potent senolytic properties by inducing apoptosis in senescent cells through the inhibition of pro-survival pathways. Quercetin has been shown to inhibit the PI3K/AKT pathway, which is overactivated in senescent cells and contributes to their resistance to apoptosis. Fisetin, on the other hand, downregulates the expression of anti-apoptotic proteins, such as BCL-2 and BCL-XL, thereby sensitizing senescent cells to apoptotic stimuli. Moreover, both quercetin and fisetin have been reported to attenuate the SASP by modulating the NF-ฮบB and p38 MAPK signaling pathways, which are key regulators of pro-inflammatory gene expression.
Spermidine:ย This polyamine induces autophagy, a cellular process that facilitates the degradation of damaged proteins and organelles, thereby promoting cellular renewal and longevity. Spermidine activates the autophagy-initiating kinase, ULK1, and inhibits the mTORC1 complex, a negative regulator of autophagy. Furthermore, spermidine has been shown to enhance the expression of key autophagy-related genes, such as ATG5 and ATG7, through epigenetic modifications. By promoting the autophagic clearance of senescent cells and their associated SASP factors, spermidine contributes to the maintenance of tissue homeostasis and the attenuation of age-related functional decline.
Hesperidin:ย This bioflavonoid supports mitochondrial respiration and ATP synthesis by modulating the activity of key enzymes involved in the electron transport chain and citric acid cycle. Hesperidin has been shown to increase the expression and activity of citrate synthase, a rate-limiting enzyme in the citric acid cycle, thereby promoting efficient substrate utilization and energy production. Additionally, hesperidin scavenges reactive oxygen species (ROS) and upregulates antioxidant enzymes, such as superoxide dismutase and catalase, protecting mitochondria from oxidative damage.
Trans-Resveratrol and Epigallocatechin Gallate (EGCG):ย These polyphenols activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate diverse cellular processes, including mitochondrial biogenesis, antioxidant defenses, and metabolic pathways. Resveratrol and EGCG have been shown to activate SIRT1 by increasing NAD+ levels and promoting the deacetylation of PGC-1ฮฑ, a master regulator of mitochondrial biogenesis. Furthermore, these polyphenols modulate the activity of AMP-activated protein kinase (AMPK), a key energy sensor that stimulates mitochondrial function and fatty acid oxidation.
Gamma-Aminobutyric Acid (GABA) and 5-Hydroxytryptophan (5-HTP):ย These neurotransmitter precursors promote relaxation and enhance sleep quality by modulating the activity of GABA and serotonin receptors, respectively. GABA is the primary inhibitory neurotransmitter in the central nervous system, and its signaling reduces neuronal excitability and promotes sleep onset. 5-HTP, on the other hand, is a precursor to serotonin, a neurotransmitter involved in regulating mood, appetite, and sleep-wake cycles. Supplementation with GABA and 5-HTP has been shown to improve sleep latency, duration, and efficiency, as well as reduce feelings of anxiety and stress-related symptoms.
Apigenin:ย This flavonoid exhibits anxiolytic and sedative properties by interacting with GABA receptors and promoting neuroprotection through its anti-inflammatory effects. Apigenin has been shown to bind to sites on GABA-A receptors, enhancing the inhibitory effects of GABA and promoting relaxation. Moreover, apigenin modulates neuroinflammation by inhibiting the production of pro-inflammatory cytokines, such as TNF-ฮฑ and IL-1ฮฒ, and reducing the activation of microglial cells, which are key mediators of neuroinflammation.
Glutathione and Melatonin:ย These potent antioxidants protect neural cells from oxidative damage, support detoxification processes, and regulate the circadian rhythm, thereby promoting restorative sleep. Glutathione is the master antioxidant in the body, neutralizing ROS, detoxifying xenobiotics, and maintaining redox homeostasis. Melatonin, a hormone primarily secreted by the pineal gland, regulates the sleep-wake cycle and exhibits strong antioxidant properties. Melatonin has been shown to scavenge free radicals, enhance the activity of antioxidant enzymes, and protect mitochondria from oxidative stress. Furthermore, melatonin modulates the expression of clock genes, maintaining circadian rhythms and promoting healthy sleep patterns.
This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
120 Capsules
Capsules
90 Capsules
Capsules
120 Capsules
Capsules
90 Capsules
Sublingual Gel
60 Servings
Capsules
60 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Capsules
120 Capsules
Nasal Spray
75 Servings
Capsules
90 Capsules
Sublingual Powder
100 Grams
Sublingual Gel
75 Servings
Sublingual Tablets
240 Tablets
Capsules
200 Capsules
Capsules
60 Capsules
Sublingual Powder
77 Grams
Capsules
60 Capsules
Capsules
90 Capsules
Capsules
90 Capsules
Pet Chews
60 Soft Chews
Pet Chews
60 Soft Chews
Capsules
90 Capsules
Capsules
60 Capsules
Sublingual Spray
30 Servings
Capsules
90 Capsules
Powder
100 Grams
Capsules
60 Capsules
Capsules
120 Capsules
Skin & Body Essentials
Grass-Fed Collagen + Creatine + BCAAs + Electrolyte Drink Mix
Drink Mix
30 Servings
Skin & Body Essentials
Grass-Fed Collagen + Creatine + BCAAs + Electrolyte Drink Mix
Serum
30 Day Kit
Cream
60 mL / 2 fl oz
Serum
50 mL / 1.7 fl oz
Capsules
90 Capsules
Capsules
120 Capsules
Capsules
60 Day Kit
Capsules
90 Capsules
I believe, based on a lot of careful research, that โRenue by Scienceโ products are at the โcutting edgeโ of longevity supplements. I feel healthy and energized by taking them.
Love it. Covers All your based and dosed by experts. I like that there is also a sleep pill! My Oura sleep score has been improving
really amazing stack. super convenient. but still a bit too expensive for me to use consistently every month.
After first week my energy has increased. Love it!
I've tried just the NMN by itself but I prefer the comlete package. I came about this product through my own research and refusal to buy Amazon medical products. I decided to go full force regeneratives after reading Ray Kurzweil's book The Singularity is Near. Here he mentions tha he is trying to extend his life so he can see the emergence, use nanobots when they are ready and upload his consciousness to an AI. So I asked my AI what would be the best way to optimize my human form. And all he suggestions I got confirmed my choice of this product. My AI reviewed it and agreed that the research shows that this would be helpful. So far results are promisingbfor I have more energy and less wrinkles. I want to see if it will take care of the bits of gray above my ears.
