NMN is a natural compound known to boost NAD+ levels.โ
SLC NMN is designed to maximize NMN uptake, restore methylation, and support the immune system.โ
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Serving size 1 capsule
NMN is a natural compound known to boost NAD+ levels.โ
SLC NMN is designed to maximize NMN uptake, restore methylation, and support the immune system.โ
Serving size 1 capsule
NAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. SLC NMN helps boost NAD+ production by providing NMN, a direct precursor to NAD+.โ
โTogether, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.โ (1)
Nicotinamide mononucleotide (NMN) is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:
NAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases.โ ย This makes increasing NAD+ levels a promising therapeutic target.โ
NMN serves as a direct precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.โ
SLC NMN is designed for enhanced absorption by promoting its interaction with the NMN transporter, Slc12a8.โ
This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.
This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.
This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.
Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.
A 2019ย studyย found some NMN can be transported directly through the cell membrane by the Slc12a8 Transporter and converted to NAD+ inside the small intestine.
The results from their study showed that older mice had increased levels of the transporter, leading to greater increases in NAD+ levels after NMN supplementation compared to young mice.
โโโTherefore, increasing NMN availability or stimulating the function of the NMN transporter could effectively counteract age-associated NAD+ decline in the aged small intestine.โ
However, anotherย studyย showed that most NMN is degraded by bacteria in your gut, limiting the amount of NAD+ that can be produced from standard NMN formulations.
Link to study:ย Hostโmicrobiome interactions in nicotinamide mononucleotide (NMN) deamidation
These figures show the effect of gut bacteria on the intestinal levels of NMN (on the left) and NAD+ (on the right) after NMN supplementation.
The pink and red bars represent mice given antibiotics to deplete their gut bacteria. Their levels are many times higher than mice with normal gut bacteria.
SLC NMN uses a specially designed capsule that safeguards NMN from degradation by gut bacteria, ensuring that it arrives intact at the Slc12a8 transporter in your gut.โ
This unique NMN formulation features a number of key advantages to enhances absorption through Slc12a8 and promote your overall well-being:
All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.
We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.
Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.
Frequently Asked Questions
Delivery Systems to Improve Absorption
Several delivery systems have been developed to protect NAD+ and precursors from being broken down and to enhance their absorption.
In other products, we use advanced Liposomal technology which protect NAD+, NMN, and NR from degradation in the GI tract and liver, but this delivery system adds significant cost.
We are committed to providing diverse and effective delivery methods that cater to various budgets and preferences. We believe that enteric (acid-resistant) capsules are superior to the standard capsules sold online, offering improved absorption at a lower cost than our competitors.
The enteric coated (acid-resistant) capsules are specifically designed to protect ingredients from the harsh acidic stomach, while safeguarding them from being degraded and digested by bacteria and enzymes.
The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract - with NAD+ precursors being particularly vulnerable to this.
The enteric (acid-resistant) capsules safeguard the ingredients to support better absorption, and a slowerย releaseย into the bloodstream.
Amino acid for sleep and mood
Polyphenol protection
Full-spectrum adaptogen
Cardioprotection and metabolism
Promote immunity and heart health
Mitochondrial and metabolic health
Liposomal Berberine, Red Yeast Rice, CoQ10
Generating cellular energy
Essential vitamins for bone mineralization and growth
Liposomal Hesperidin, Green Tea, Resveratrol
Naturally occurring senolytic
Neurotransmitter for mood and sleep
Powerful antioxidant polyphenol
High absorption form of the master antioxidant
Citrus-sourced inflammation and heart support
Skin, joint and bone health
Natural hormone for sleep support
Comprehensive NAD+ Support
Convenient cognitive boost
NAD+ Precursor
Fast dissolve NAD+ boosting powder
Cellular vitality and well-being
Convenient NAD+ boosting sublingual tablets
Delayed release NAD+ booster
Delayed release NAD+ booster
Sublingual citrus burst NAD+ boost
Delayed release for improved absorption
Natural building block for NAD+ production
Neuroprotective inflammation support
Feline longevity formula
Canine longevity formula
Senolytic flavonoid and inflammation support
Liposomal Gaba, Apigenin, Glutathione, 5-HTP, Melatonin
Rapid absorption sleep support
Sirtuin activating polyphenol
Sirtuin activating polyphenol
Support cellular health and rejuvenation
Liposomal Vitamin C, CaAKG, P.E.A., HLA
Grass-Fed Collagen + Creatine + BCAAs + Electrolyte Drink Mix
Restore skin's natural radiance
Powerful skin rejuvenation
Powerful skin rejuvenation
Polyamine preserves NAD+ against inflammation
Comprehensive defense against the damage of aging
NAD+ boosting methylated niacin
Incredible product ๐ฉท
Product is very good. I have been taking these pills for 20 months. I found that give me energy and keep me younger than my age. I took 2pills per day.
Great product - high quality, I give it to my dog. It's difficult to see if there are improvements specifically from the NMN. He's 8 and has arthritis, with two TPLO surgeries under his belt, but I plan to give it to him long term. I also have him on Theracurmin, bpc-157 and TB500, so it's a multifaceted approach, but he is definitely a lot less stiff when first getting up to walk. Best price and quality you're going to get for NMN.
I had a bad reaction the capsule form of NMN (stomach pain/nausea) I will be contacting customer support and switching back to the powder.
There are no studies that confirms that the SLC Enteric NMN is a eficient way to absorve NMN to the blood stream
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โ These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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