NEW

NEW

NEW

NEW

NEW

Recommended 2 Pumps

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Name: Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)
Brand: Renue Store
SKU: 850055685215
Price: 59.95 USD
Availability: InStock

Convenient cognitive boost

$59.95 USD

Shipping calculated at checkout.

If you’re looking for a convenient on-the-go product, our NAD+ nasal spray is the perfect complement to your main NAD+ supplements.

The NAD+ nasal spray provides targeted delivery, focusing on the brain, rather than widespread systemic circulation. It’s designed to have a stronger effect on cognition and brain fog than all other delivery methods.†

Product variants

Recommended 2 Pumps

Liposomal NAD+ Complete Nasal Spray

Support Cognition with our NAD⁺ Nasal Spray

If you’re looking for a convenient on-the-go product, our NAD+ nasal spray is the perfect complement to your main NAD+ supplements.

The spray provides targeted delivery, focusing on the brain, rather than widespread systemic circulation.

NAD+ nasal spray is designed to have a stronger effect on cognition and brain fog than all other delivery methods.† This spray is intended to enhance, not replace, your existing NAD+ supplementation.

Why Intranasal Delivery Is Highly Effective

Intranasal delivery is the one of the quickest and most effective ways to deliver NAD⁺ and its precursors, NMN and NR, into the body. The nasal mucosa’s rich blood flow allows for optimal drug absorption while avoiding the first-pass effect. (1)

The first pass effect refers to drugs getting metabolized at specification locations in the body, most often the liver, which results in the drug’s reduced concentration in systemic circulation or at the target site.

“Furthermore, the drugs administered using nasal route have usually higher bioavailability, less side effects and result in higher brain exposure at similar dosage than the oral drugs.” (2)

Improving NAD⁺ through Multiple Pathways

While there is a lot of uncertainty about the pathways NAD⁺ and NAD⁺ precursors take in the body, we do know that there are differences between them, and they have affinity for different tissues. We believe the most effective protocol to increase NAD⁺ is through targeting multiple pathways.

View full details

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Enhanced Bioavailability

Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.

Learn More

Research

Liposomes Increase Bioavailability

With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.

For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.

With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.

Hence the study below shows it is about 10x more bioavailable.

Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.

Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.

Learn More

Frequently Asked Questions

When do LIPO gel products expire?

LIPO gel products are good for 2 years from the date of manufacture printed on the bottle.

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.