Restore PM is formulated with ingredients that work with your body's natural sleep-wake rhythms, without relying on sedatives or habit forming substances.
Each ingredient is available separately in addition to the complete blend, ensuring you have the sleep support you need as a nightly ritual or on those nights when sleep seems most elusive.
GABA
This inhibitory neurotransmitter promotes relaxation and reduces neuronal excitability. Liposomal delivery of GABA enhances its absorption, allowing it to efficiently cross the blood-brain barrier, where it helps to induce calm and support restful sleep. GABAergic activity sets the stage for deep, restorative sleep by allowing the neurons that are overexcited with thoughts and physical stress to instead come to a more restful state, promoting tranquility and restfulness.
5-HTP
5-Hydroxytryptophan (5-HTP) is a direct precursor to serotonin, the neurotransmitter thought to be the most critical for mood regulation and sleep initiation. Liposomal encapsulation of 5-HTP ensures optimal bioavailability, promoting serotonin synthesis in the brain. This facilitates the onset of sleep and stabilizes mood, gently guiding the transition to a restful night.
Apigenin
Apigenin is a bioactive flavonoid that has been shown to modulate GABA receptors and exert anti-inflammatory effects. Found in chamomile, this compound may be responsible for this tea's notorious relaxing effect. Through liposomal delivery, apigenin’s bioavailability is significantly enhanced, enabling it to effectively reduce anxiety and support the onset of sleep. Its dual action on the nervous and immune systems promotes overall relaxation and sleep quality.
Glutathione
As the body's master antioxidant, glutathione supports healthy detoxification, cellular repair, and immune function. Traditional glutathione is poorly absorbed. Liposomal glutathione enhances its ability to neutralize oxidative stress and support brain health during sleep.
Melatonin
Melatonin is the hormone responsible for regulating the sleep-wake cycle, and natural secretion not only diminishes with age, but can be impacted by exposure to unnatural light cycles. Liposomal delivery increases its absorption, supporting rapid onset of sleep by signaling to the brain that it’s time to rest. This helps align your body’s circadian rhythm, promoting a deep and uninterrupted sleep cycle so you wake refreshed and clear-headed in the morning.
Learn More About Liposomal Delivery
Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)
This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.
The aim of taking any supplement is to ensure its transport into the bloodstream.
However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys.⑵
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability.
The higher the bioavailability of an active substance, the more effect it has on the body.
Research
Liposomes Increase Bioavailability
With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.
For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.
With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.
Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.
Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.
Are any of your liposomal products heat-sensitive?
The liposomal powder capsule products are not heat sensitive.
The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.
What's the difference between Liposomal vs. Delayed & Extended Release Caps?
Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.
Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).
In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.
What are the liquid and powdered liposome differences in bioavailability and stability?
Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.
Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.
What are the benefits of liposomal delivery? Are liposomes really better?
When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.
A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.
Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.
The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.
Love it, sleep deeply! Thanks, love all your products!
A
Amy
Made sleep worse
Didn't work. I tried for a week and actually woke up more during the night than without it
C
Carrie
Actually works!
Actually works! I’m amazed that one of these helps me sleep better than any other product.
J
Jim
Not enough melatonin
Not enough melatonin. Seniors Ned melatonin. Your old one had 3.5 versus 1 mg for this one
M
Mike
really good combination of compounds
really good combination of compounds, really appreciated low melatonin value i'm about 10 days in, maybe psychosomatic but feeling like i slept better and woke up feeling better, i'm a masters athlete so there could be much value in this.