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The traditional routes of administration are limited by the blood brain barrier (BBB).
Intranasal delivery bypasses the BBB and quickly delivers the active ingredients directly to the brain through the olfactory and trigeminal nerves.
Here we'll share some highlights from the research involving intranasal delivery of NAD+ for brain injuries in mice.
Graphics from the study: (Pandya, J.D., Musyaju, S., Modi, H.R. et al., 2024 | Journal of Translational Medicine)
What the Studies Revealed
- Reduced brain injury in rats after stroke
- Prevented brain cell death in rats after head injury
- Slowed down the progression of brain infection in mice
This figure illustrates the neurological function assessed 24 hours after the stroke.
Rats receiving intranasal NAD+ (white bar) exhibited markedly fewer neurological deficits compared to untreated rats (black bar).
Disclaimer:
This email references ongoing research and it's important to note that:
- This research is preliminary and has been conducted solely in animal models (mice and rats).
- No human studies have been published on nasal administration of NAD+ or NAD precursors.
- Further studies, including clinical trials in humans, are required to determine potential efficacy in humans.
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NMN Extended Lifespan in Fast-Aging Mice
RESEARCH
A recent study investigated the effects of NMN supplementation on health and aging in mice. The researchers used a mouse model designed to prematurely age the animals. Mice who were fed NMN fared better in several metrics, including longevity.
Key Points:
- NMN showed benefits at a higher dose, equivalent to 24 mg/kg in humans
- NMN extended Lifespan
- NMN reduced Frailty
- NMN enhanced weight gain
“The median lifespan of the mice increased from 21.4 weeks to 25.7 weeks, representing an increase of more than 20%.”
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Just want to give a shout to this combo because it has been amazing for me to getting to sleep within 20 minutes of laying down. The Restore PM is good on its own, add in the Ashwagandha and it is night night time 20 minutes later...incredible combo if you are in need of a good night of sleep.
That is all, carry on.
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