Keep Zombie Cells at Bay

Fisetin – The Zombie-Fighting Flavonoid

Found naturally in strawberries, apples, and grapes, fisetin is a flavonoid with strong senolytic activity. Research indicates it can help clear senescent cells, rejuvenating tissues by promoting cellular health and resilience.

Animal studies suggest that fisetin's benefits extend to the brain, where it may help preserve cognitive function by dampening inflammation and oxidative stress—key factors linked to brain aging. (1, 2)

Quercetin – The Cellular Cleanser

Found in fruits and vegetables, quercetin is a known antioxidant with senolytic effects. Studies show that quercetin may help protect against oxidative stress and support cellular cleanup, which benefits brain and immune health.

It’s been studied for its role in promoting cellular health in brain tissues, where it may aid in maintaining cognitive function through its stress-shielding properties. (3, 4)

Spermidine – The Undead Cleanup Crew

Spermidine, naturally present in grains, aged cheeses, and mushrooms, has been shown to support autophagy, the body’s process for clearing out cellular debris, including “zombie” senescent cells. One study showed its potential to significantly delay senescence in stem cells, supporting systemic rejuvenation. (5, 6)

Heather

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Heather L. Makar is a biologist, longevity futurist, TEDx speaker, and science writer focused on translating complex mechanisms of aging into strategies for healthspan extension. At Renue By Science, she leads research-driven content strategy that empowers readers to understand, optimize, and evolve their own biology. She brings a multidisciplinary perspective to health optimization, bridging natural medicine and cutting edge science to build actionable protocols that have tangible effects immediately and far into the future.