Meta-Review: NMN Promotes Liver and Muscle Health in Middle Aged and Older Adults

Introduction: Nicotinamide Mononucleotide (NMN) has gained attention as a precursor to Nicotinamide Adenine Dinucleotide (NAD+) in recent years, commonly utilized in anti-aging therapies. The anti-aging effects of NMN on muscle and liver functions in middle-aged and elderly people are still unclear.

Objective: Based on available randomized controlled trials, we conducted a meta-analysis to evaluate the impact of NMN on muscle and liver functions in middle-aged and elderly individuals.

Methods: We conducted searches on three electronic databases (PubMed, Embase, Web of Science) for randomized controlled trials involving NMN interventions in middle-aged and elderly populations. Through the Cochrane Handbook, we assessed the specific methodological quality. All statistical analyses were obtained by Stata15, and statistical significance was set as P<0.05.

Results: There were 412 participants from 9 studies in this meta-analysis. Based on changes in gait speed (SMD: 0.34 m/s, 95%CI <0.03, 0.66> p = 0.033), NMN had significant effects on muscle mass. Moreover, NMN had a better effect on ALT (SMD: -0.29 IU/L, 95%CI <-0.55, -0.03> p = 0.028). Subgroup analysis indicated that administering a small dose of NMN exerted the most prominent impact on Homeostasis Model Assessment-Insulin Resistance (HOMA-IR).

Conclusion: NMN has positive efficacy in enhancing muscle function, reducing insulin resistance and lowering aminotransferase levels in middle-aged and elderly individuals. NMN is an encouraging and considerable drug for anti-aging treatment.

Summary

This meta-analysis of 9 randomized controlled trials with 412 participants evaluated the effects of NMN on muscle and liver function in middle-aged and elderly individuals. The study found that NMN significantly improved muscle mass and gait speed, reduced insulin resistance, and lowered liver enzyme levels.

Heather

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Heather L. Makar is a biologist, longevity futurist, TEDx speaker, and science writer focused on translating complex mechanisms of aging into strategies for healthspan extension. At Renue By Science, she leads research-driven content strategy that empowers readers to understand, optimize, and evolve their own biology. She brings a multidisciplinary perspective to health optimization, bridging natural medicine and cutting edge science to build actionable protocols that have tangible effects immediately and far into the future.