Liposomal Apigenin & Deep Sleep Study
A real-world study exploring whether nightly liposomal Apigenin supplementation influences deep sleep duration in adults with low baseline deep sleep levels, measured by wearable sleep trackers over 30 days.
View Full ResultsExploring Liposomal Apigenin and Deep Sleep
Renue By Science Research conducted a real-world study to explore whether nightly liposomal Apigenin supplementation influences deep sleep duration in adults who report low baseline deep sleep levels (<60 minutes per night on average).
Participants tracked their sleep using their own wearable devices β Oura Ring, Whoop, or Fitbit β throughout a baseline week and a 30-day supplementation phase. The study used objective wearable data alongside daily self-assessments to evaluate changes in sleep architecture.
How the Study Was Conducted
Methodology
Baseline Week
Participants tracked one full week of normal sleep using their wearable device (Oura, Whoop, or Fitbit) to establish a personal baseline. Those averaging less than 60 minutes of deep sleep per night were eligible to continue.
30-Day Supplementation Phase
Participants took liposomal Apigenin each night before bed for 30 consecutive days while continuing to track sleep with their wearable device. Nightly data was captured automatically via device sync.
Data Collection & Analysis
Wearable deep sleep data from the supplementation phase was compared against each participant's baseline week. Group averages and individual response patterns were analysed by the Renue By Science Research team.
Key Findings
Study Results
Deep Sleep Increased Significantly
After taking LIPO Apigenin for one month, the average length of deep sleep for the participants increased from 32 minutes to 74 minutesβ *.
That's an improvement of 130% in deep sleep durationβ *.
Stronger Results at Higher Doses
Those taking 2 or 3 capsules a day reported the largest increase in deep sleepβ *.
Some participants increased from <15 minutes β >40 minutes per nightβ *.
Fast, Noticeable Effects
Several participants reported:
- Deep sleep decreased when supplementation stoppedβ *
- Deep sleep increased again upon restartingβ *
This pattern suggests a direct, short-term effectβ *.
Additional Observations
Some participants also reported:
- Fewer nighttime awakeningsβ *
- Increased dream activityβ *
- Improved perceived recoveryβ *
These outcomes were not consistently measured and require further study.
Interpretation
The effect of apigenin on sleep is not new, but the magnitude and consistency observed here were notableβ *.
One possible explanation is the use of liposomal delivery, which could improve bioavailability and promote sustained release, which might help support normal sleep-related physiologyβ *.
Limitations
- Small sample size (~32 participants)
- Not placebo-controlled
- Self-selected participants with low baseline deep sleep
- Reliance on wearable device data
β These findings come from a small, uncontrolled pilot study in which participants received the product at no cost. Additional larger, controlled, and peer-reviewed studies are needed to confirm these results.
*The statements on this website have not been evaluated by the Food and Drug Administration. Our products are dietary supplements and are not intended to diagnose, treat, cure, or prevent any disease. The content provided is for educational purposes only and is not medical advice. Always consult a healthcare professional before using any supplement.
Panel Composition
Participants
Study Information
