The Future of Bioavailability Is Here

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Why Liposomal Delivery Changes Everything. 

Most oral supplements are broken down by the digestive system before they ever reach your cells. That’s why we created our liposomal formulas—to safeguard absorption and maximize results.

Liposomes are microscopic spheres made of the same phospholipids that make up your cell membranes. When active ingredients are encapsulated inside these lipid layers, they’re protected from stomach acid and digestive enzymes—delivering them more efficiently to your bloodstream and, ultimately, your cells.

At Renue By Science, we’re redefining bioavailable longevity science.

What Happens Inside the Body?

Not all supplements are absorbed equally. The delivery system determines how much of the active compound reaches your bloodstream—and whether it ever makes it into your cells.

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Traditional Capsules: A Digestive Gauntlet

When you swallow a standard supplement capsule, it must first dissolve in the stomach—an environment with highly acidic pH and digestive enzymes that can degrade fragile compounds.

From there, the nutrient must survive passage through the small intestine, where it encounters additional enzymes, variable pH levels, and selective transport proteins that may block or slow its uptake. Even after absorption into the bloodstream, some molecules are rapidly metabolized by the liver—a process known as first-pass metabolism—reducing the amount that ultimately reaches cells.

For compounds like NMN, glutathione, resveratrol, and CoQ10, this digestive process can severely limit their bioavailability. What you swallow isn’t always what your body can use.

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Liposomal Delivery: Bypassing Barriers

Liposomes change the equation. These microscopic spheres are composed of phospholipid bilayers—the same structure as your cell membranes.

This design gives them two key advantages:

Protection: The active compound (such as NMN or glutathione) is encapsulated within the liposome, shielding it from stomach acid, digestive enzymes, and oxidative degradation during transit.

Absorption: Because liposomes mimic the membrane structure of human cells, they fuse easily with intestinal cell walls and cellular membranes. This fusion allows them to deliver their contents directly into the bloodstream and, ultimately, inside the target cells—without relying on transporters or passive diffusion.

From Ingestion to Intracellular Delivery

  • After ingestion, liposomal particles remain stable through the digestive tract.
  • In the small intestine, liposomes are absorbed via endocytosis—where cells engulf the entire particle—or through direct fusion with the enterocyte membrane.
  • Once inside circulation, liposomes can be taken up by tissues and deliver their contents intracellularly, bypassing the need for metabolic conversion or enzymatic activation.

This matters for longevity molecules like NMN and NR, which must reach cells intact to effectively raise NAD+ levels. It’s also essential for redox molecules like glutathione, which are otherwise broken down in the gut and reassembled inefficiently by the liver.

Why This Matters for Aging and Healthspan

Aging cells often have compromised transport systems and lower enzyme activity. Liposomal delivery bypasses these limitations, delivering bioactive nutrients efficiently—even when cellular function is already impaired. This is one reason liposomal formulations are increasingly used in clinical settings for targeted nutrient therapy and drug delivery.

Liposomal delivery is not a marketing gimmick. It’s a biochemically superior way to ensure longevity molecules reach their targets, supporting the mitochondria, DNA repair enzymes, and signaling pathways that regulate how we age.When precision matters, so does delivery.

Traditional Supplements Fall Short

Low absorption. High waste. Inconsistent results.

Most oral supplements promise transformative effects but fail to address one core issue: bioavailability. That’s the percentage of a nutrient that actually enters your bloodstream in a form your body can use. And for many of the most powerful longevity molecules, that number is shockingly low.

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Your Digestive System Isn’t Designed for Precision Delivery.

The gastrointestinal tract is optimized to break things down, not preserve fragile nutrients. When you swallow a traditional capsule or powder:

Stomach acid degrades unstable compounds like glutathione, EGCG, and NMN before they even reach the small intestine.

Digestive enzymes metabolize nutrients into inactive forms, limiting their utility.

First-pass metabolism in the liver further reduces active compound levels before they ever reach systemic circulation.

What does that mean in real terms? Studies show that as little as 5–10% of some nutrients in standard supplements ever reach the bloodstream—and even less may cross into your cells.

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Delicate Nutrients Need Advanced Protection

This is especially true for:

  • NMN and NR, which support NAD+ production but are degraded or converted before absorption.
  • Glutathione, which is rapidly broken down in the gut and poorly reassembled by the liver.
  • CoQ10, a fat-soluble antioxidant with notoriously low absorption in capsule form.
  • EGCG, a polyphenol from green tea that oxidizes easily and has limited intestinal uptake.

No matter how high the dose, if your supplement doesn’t survive digestion and reach the bloodstream intact, you’re not getting the benefits.

From Ingestion to Intracellular Delivery

  • After ingestion, liposomal particles remain stable through the digestive tract.
  • In the small intestine, liposomes are absorbed via endocytosis—where cells engulf the entire particle—or through direct fusion with the enterocyte membrane.
  • Once inside circulation, liposomes can be taken up by tissues and deliver their contents intracellularly, bypassing the need for metabolic conversion or enzymatic activation.

This matters for longevity molecules like NMN and NR, which must reach cells intact to effectively raise NAD+ levels. It’s also essential for redox molecules like glutathione, which are otherwise broken down in the gut and reassembled inefficiently by the liver.

The Liposomal Advantage

Clinical research has shown that liposomal delivery systems can increase bioavailability by up to 10-fold compared to standard oral formulations.

This is because liposomes protect the active ingredient from degradation, bypass many digestive hurdles, and fuse directly with cellular membranes to release their payload where it matters most.

Liposomal encapsulation transforms these fragile, high-impact nutrients into efficient, cell-ready tools for improving energy metabolism, DNA repair, redox balance, and healthy aging.

It’s not just about getting more—it’s about getting it where it counts.

Liposomal Delivery: Backed by Clinical Evidence

More than a theory—it's measurable.

Liposomal delivery isn’t just a marketing term. It’s a well-studied pharmaceutical strategy originally developed to improve the therapeutic index of drugs with poor absorption, instability in the GI tract, or low cellular uptake. Now, that same technology is being used to transform how we absorb nutrients central to human longevity.

Liposomes: A Smarter Delivery System

Designed for precision. Built for bioavailability.

Each liposome used in our formulations is engineered for:

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Enhanced protection of sensitive ingredients through the digestive tract

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Improved transport across intestinal and cellular membranes

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Superior absorption into the bloodstream

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Targeted delivery to tissues where it’s needed most

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Here’s what the science says:

NMN: Liposomal NMN Outperforms Standard NMN

NMN: Liposomal NMN Outperforms Standard NMN

A 2023 double-blind, placebo-controlled human study compared liposomal NMN, non-liposomal NMN, and placebo over 4 weeks. Results showed:

  • 84% increase in NAD+ levels in the liposomal NMN group (from 28.6 µM to 52.5 µM)
  • Liposomal NMN significantly outperformed standard NMN at the same dose (350 mg/day)
  • NAD+ levels remained elevated four weeks after discontinuation, indicating sustained cellular uptake

The researchers stated:

“Liposomal NMN is directly absorbed into the cells in its original form through the cell membrane. This allows for efficient NAD+ production within the cells, without the need for energy consumption or a reduction in NMN levels.”

https://acmcasereport.org/wp-content/uploads/2025/02/ACMCR-v14-2340.pdf

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Liposomal Curcumin Shows 2x–6x Greater Potency

Curcumin is well-known for its antioxidant and anti-inflammatory properties—but in its natural form, it’s limited by poor solubility and low bioavailability. The Basnet et al. study demonstrated that encapsulating curcumin in liposomes significantly boosts its biological activity. In cell studies, liposomal curcumin outperformed non-liposomal forms by 2 to 6 times in reducing inflammatory markers like nitric oxide, IL-1β, and TNF-α. It also enhanced antioxidant defenses through greater activation of superoxide dismutase (SOD). The liposomal formulation allowed for stable incorporation of curcuminoids into phospholipid bilayers and improved uptake by cells—highlighting how delivery method makes the difference between a promising compound and a potent one.

https://www.sciencedirect.com/science/article/abs/pii/S0022354915317147

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Liposomal Glutathione Increases Systemic Levels and Redox Capacity

A 2017 randomized, double-blind, placebo-controlled trial published in the European Journal of Clinical Nutrition evaluated the effects of liposomal glutathione on blood glutathione levels, oxidative stress markers, and immune function.

Participants who took 500 mg or 1,000 mg of liposomal glutathione daily for 4 weeks showed:

  • Up to a 40% increase in reduced glutathione (GSH) levels in whole blood, red blood cells, and PBMCs.
  • Significant reduction in oxidative stress markers, including a 35% decrease in 8-isoprostane.
  • Improved immune function, with a 400% increase in natural killer (NK) cell cytotoxicity from baseline in the high-dose group.

These results confirm that liposomal delivery enables glutathione to be absorbed intact into circulation—something traditional oral glutathione struggles to achieve due to rapid degradation in the gastrointestinal tract.

https://www.nature.com/articles/ejcn2017132

Why Liposomal Green Tea Works Better

Green tea is renowned for its catechins—especially EGCG (epigallocatechin gallate)—which have been linked to metabolic balance, cardiovascular health, antioxidant defense, and healthy inflammatory signaling. But here's the problem: most green tea extracts fall short in bioavailability, meaning only a fraction actually makes it into your bloodstream.

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That’s where liposomal delivery changes the equation.

A rigorous 2-arm crossover study compared standard green tea extract to a liposomally encapsulated green tea formulation. Each participant took both versions, separated by a washout period.

Based on this data from the unpublished 24-hour crossover trial conducted in 26 healthy adults comparing a liposomal green tea extract to a standard extract, researchers found:

  • Up to 5x higher peak blood levels (Cmax) of EGCG, EGC, and other key catechins from the liposomal version.
  • Sustained plasma concentrations for over 12 hours post-dose—whereas the generic extract declined sharply after just 2–3 hours.
  • Total catechin exposure (AUC) was dramatically higher with liposomal delivery, indicating better systemic availability.
  • The liposomal formulation maintained measurable catechin levels at 24 hours, while the standard extract dropped to near-baseline.

These differences are not minor. They’re the difference between hoping your supplement works—and knowing it’s reaching your cells.

That matters for longevity because:

  • EGCG and its sibling catechins have been shown to modulate AMPK and sirtuin activity, both deeply involved in aging pathways.
  • They support autophagy and mitochondrial efficiency, processes that decline with age but are vital to cellular renewal.
  • Their antioxidant effects reduce oxidative stress—a key driver of cellular damage over time.

The challenge has always been getting enough of these molecules into circulation. This data makes it clear: liposomal delivery solves that.

If you're supplementing green tea for longevity, absorption isn't optional. It’s everything.

Bottom line?

Liposomal delivery dramatically improves absorption, cellular uptake, and efficacy—especially for longevity molecules with low oral bioavailability or high GI degradation.

What Makes Our Liposomes Different?

Not all liposomes are created equal. Many are unstable, too large, or made with cheap synthetic materials. We go further by:

  • Using natural phospholipids, modeled after your own cell membranes.
  • Creating uniform liposome sizes for optimized uptake.
  • Testing every batch for stability, potency, and absorption.

You’ll find our liposomal delivery system across a wide range of Renue formulas—from NAD+ precursors to powerful polyphenols.

Better Delivery. Better Results.

Liposomal delivery isn’t just about better absorption—it’s about building formulas that work the way your body does. If you’re investing in advanced molecules for longevity, don’t compromise on how they’re delivered.

Explore our full line of liposomal supplements and experience the difference.

Shop Liposomal Formulas

Frequently Asked Questions

Do I Really Need This Kind of Absorption?

Even the most well-formulated supplement can fall short if the active ingredient never reaches your cells. Liposomal delivery enhances absorption, protects fragile molecules from degradation, and ensures nutrients are absorbed into the bloodstream intact—where they can support the processes that matter most: energy production, DNA repair, inflammation regulation, and cellular signaling.

Can’t I just take more of a regular supplement?

Not effectively. Doubling the dose doesn’t double the absorption. It increases waste and can burden detoxification systems like the liver and kidneys. Most standard supplements pass through the digestive system with limited uptake—especially those with low water solubility, like CoQ10 or resveratrol. Liposomal forms solve this by improving bioavailability through direct cell membrane fusion.

I eat healthy—do I really need supplements?

Even with a clean diet, age-related changes in enzyme activity, nutrient transport, and mitochondrial function limit how efficiently we convert and absorb what we eat. Whole foods are foundational, but they don’t deliver targeted molecules at therapeutic doses. Liposomal supplements fill the gap between nutrition and function—especially for molecules shown to decline with age, like NAD+, glutathione, and phospholipids.

Isn’t liposomal delivery just for people with gut issues?

No—though people with impaired digestion do benefit, liposomal delivery is optimal for anyone who wants reliable, high-efficiency absorption. It bypasses variability in stomach acid, digestive enzymes, and microbiota, offering more consistent cellular uptake across individuals.

Is the technology safe?

Yes. Liposomes are made from natural phospholipids—the same material that forms your cell membranes. They’ve been used in pharmaceutical delivery for decades, with a well-documented safety profile. In supplements, they mimic the body’s own systems for nutrient transport.

How will I know it’s working?

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Liposomal supplements don’t rely on megadoses to compensate for loss during digestion—they’re designed for cellular impact. Many users report steady energy, faster recovery, improved focus, or better sleep—hallmarks of healthier mitochondria and improved redox status. For quantifiable changes, our at-home NAD+ test is a way to see how well your body is responding to NAD+ precursors.