Key Points
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NR supplementation significantly increased NAD+ levels
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Blood pressure was reduced in the NR group
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The health and function of blood vessels improved in the group taking NR
Study Overview
This randomized, double-blind, placebo-controlled trial included 52 adults aged 50 and older with elevated blood pressure (systolic BP ≥120 mmHg).
Participants received either 1,000 mg/day of NR or a placebo for 3 months.
Researchers measured NAD+ levels, blood pressure, and vascular endothelial function—an indicator of blood vessel health—before and after the intervention.
NAD+ Levels Increased Significantly with NR
Supplementation with NR increased NAD+ levels:
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NR group: from 20 ± 2 µM to 42 ± 6 µM
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Placebo group: no significant change (22 ± 1 µM to 25 ± 3 µM)
Heart Health Benefits Observed Only in NR Group
Heart Health Improved with NR Supplementation
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Blood pressure: Systolic blood pressure (the top number in a blood pressure reading) decreased in the group taking nicotinamide riboside, but not in the placebo group.
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Blood vessel health: The ability of blood vessels to function properly, which is important for good circulation, improved in those taking nicotinamide riboside (p=0.044), but not in those taking the placebo.
Conclusion
Three months of daily NR supplementation boosted NAD+ levels and led to measurable improvements in blood pressure and blood vessel health in older adults with elevated systolic blood pressure.
These findings suggest that NR may be a promising nutritional strategy for supporting cardiovascular health with age.
