Spermidine has been studied for a range of health-protective effects that promote healthy aging and longevity.
What is Spermidine?
Spermidine is a naturally occurring molecule that is vital to cell function and survival. It’s part of a group of molecules called polyamines. Declining polyamine levels are associated with inflammation-driven aging.
Many studies have shown the potential health benefits of Resveratrol:
Liposomal Spermidine
Although a powerful compound, Spermidine is well known for having poor bioavailability. To address this issue, LIPO Spermidine uses an advanced liposomal delivery system designed to improve the bioavailability, created for better absorption, and a slower release into the bloodstream.†
Learn More About Liposomal Delivery
Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)
This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.
What are the benefits of liposomal delivery? Are liposomes really better?
When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.
A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.
Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.
The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.
What are the liquid and powdered liposome differences in bioavailability and stability?
Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.
Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.
What's the difference between Liposomal vs. Delayed & Extended Release Caps?
Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.
Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).
In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.
Are any of your liposomal products heat-sensitive?
The liposomal powder capsule products are not heat sensitive.
The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.
Love this spermidine supplement! After taking it for several months, I bumped into two people I hadn't seen in over a year. Both of them said, "You look younger!" I don't take spermidine or anything for the purpose of having a younger appearance, but it's not surprising it seemed to have that effect. Removing poorly functioning and senescent cells makes the body healthier systemically, so it stands to reason that would reflect in one's appearance. Highly recommended!
D
David
Noticeable cognitive decline when I stop taking
Noticeable cognitive decline when I stop taking it. It is a permanent member in my supplement stack
D
Daniela
very
very good
E
Elena Plokhii
Liposomal spermidine
I am following Dr David Sinclair supplements and that’s the main reason, ordering it from your labs
Nobody else does that quality either spermidine , or liposomal spermidine as a single supplement vs part of combination of supplements
Of course, before ordering it, did the research and was confirmed that longevity supplement spermidine supports cellular autophagy
Lipo part means it increases its bioavailability