The Power of NR

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The Power of NR to Replenish NAD+

A Key to Cellular Longevity

At Renue By Science, we focus on creating data-driven, science-backed formulas that empower you to live better, longer. Nicotinamide Riboside (NR) is a foundational molecule for cellular health, offering a practical way to restore NAD+ levels and support resilience at every stage of life.



NAD+ (Nicotinamide Adenine Dinucleotide) is essential for cellular energy, DNA repair, and regulating the processes that drive metabolism and tissue healing. Yet, as we age, NAD+ levels naturally decline, leaving cells more vulnerable to damage and reducing overall resilience. NR, a direct precursor to NAD+, efficiently replenishes these critical levels, helping you maintain energy, protect cellular function, and optimize your healthspan.

Why NAD+ Matters

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Regulates Cellular Metabolism

NAD+ is a substrate for enzymes like sirtuins, which trigger metabolic processes like DNA repair, cellular energy production, and nutrient utilization. This supports efficient cellular maintenance, helping cells function at their peak.

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Promotes DNA Repair

NAD+ is necessary for the activity of poly(ADP-ribose) polymerases (PARPs), enzymes responsible for repairing damaged DNA. This helps maintain genetic integrity and ensures the proper functioning of your cells.

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Boosts Energy Levels

Mitochondria rely on a constant level of NAD+ to produce ATP, the energy currency of your cells. By replenishing NAD+ levels, NR ensures sustained energy output, delaying fatigue and promoting metabolic efficiency.

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Supports Epigenetic Health

Through its interaction with sirtuins, NAD+ influences gene expression, regulating pathways associated with stress resilience, tissue healing, and longevity. This epigenetic regulation helps preserve cellular function as we age.

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Why Choose Nicotinamide Riboside (NR)?

Nicotinamide Riboside (NR) is a scientifically validated NAD+ precursor that offers a direct, efficient way to replenish declining NAD+ levels and promote cellular health. Here's why it's one of the top choices for enhancing vitality and longevity.

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Salvage PathwayRestores NAD+ Levels Efficiently

NR is a form of vitamin B3 that your body naturally converts into NAD+ using the Salvage pathway. This process makes NR a reliable and direct method for restoring NAD+, a coenzyme essential for energy production, DNA repair, and healthy cellular function.

Think of NAD+ as the fuel that powers nearly every cell in your body. Over time, aging and stress deplete NAD+ reserves, leading to lower energy, slower repair processes, and reduced resilience to stress. By taking NR, you provide your cells with the materials they need to replenish their NAD+ supply, helping them work more efficiently.

Mechanistically, NR is absorbed into cells where enzymes, such as NR kinases, convert it via an intermediate step on the way to NAD+ synthesis. Once NAD+ is produced, it fuels vital processes such as mitochondrial energy production and the activation of repair enzymes like sirtuins and PARPs.

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NR Supports Cellular Repair and Maintenance

When NAD+ levels are restored, the entire cellular repair network becomes more active. NAD+ fuels sirtuins, enzymes that regulate cellular repair and metabolism, helping to maintain genetic stability and protect against the damage caused by oxidative stress.

This means that with NR supplementation, you may feel more energized and notice improvements in overall health. Over time, the effects of sustained NAD+ levels include faster recovery from stress, increased mental clarity, and a renewed sense of optimism and motivation.

At the cellular level, NAD+ also drives DNA repair through enzymes like poly(ADP-ribose) polymerases (PARPs). These enzymes fix breaks in DNA strands caused by everyday wear and tear or exposure to environmental toxins, preserving the integrity of your genetic code.

Supports Metabolic Health and Insulin Sensitivity

NR has been studied for its effects on metabolic health, particularly its ability to protect insulin sensitivity and support glucose regulation.

A study in Scientific Reports reported that NR supplementation improved insulin sensitivity and reduced liver fat accumulation in prediabetic mice, suggesting potential benefits for managing metabolic disorders. (5)

Practical and Safe for Long-Term Use

NR is not only effective but also safe. Clinical trials have consistently reported no significant adverse effects, even with prolonged supplementation at therapeutic doses. This makes NR a practical and reliable option for anyone seeking to enhance their healthspan and energy levels as they age.



With robust scientific backing, NR stands out as a validated solution for restoring NAD+ levels, protecting cellular function, and promoting overall vitality. These findings make it an essential choice for those looking to take proactive control of their long-term health.

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Slowing Age-Related Decline

Emerging research highlights NR’s potential to mitigate age-related conditions by promoting cellular repair and reducing oxidative stress:

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DNA Repair 

Studies have shown that NAD+ levels are essential for DNA repair mechanisms. By raising NAD+, NR activates enzymes like PARPs that fix damaged DNA, preserving genomic stability. (6)

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Oxidative Stress Reduction

Research in Aging Cell demonstrated that NR supplementation reduced markers of oxidative stress in aged cells, protecting against cellular damage. (7)

Liposomes for Maximum Absorption

Many popular supplements have poor bioavailability, greatly limiting their effectiveness. Liposomes are the solution, encapsulating active ingredients and protecting them until they reach the bloodstream.

BIOAVAILABILITY: The NAD⁺ Precursors and longevity supplements other manufacturers sell suffer from very poor bioavailability.

LIPOSOMAL TECHNOLOGY: Liposomes encapsulate the active ingredients in a phospholipid bubble to protect them from digestion.

RESEARCH: Greatly improved bioavailability from Liposomal Delivery maximizes the effectiveness of our products.

Read More about The Liposome Advantage

4 Pathways to Restore NAD+

NAD+ Complete

Senolytique

Shield

Energizer AM

THE LIPOSOME ADVANTAGE

Liposomes encapsulate active ingredients to protect them from stomach acid and enzymes so they can be delivered directly to the cells of our tissues, which are reached via the bloodstream. (1)

Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

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NAD+ Supplements

NAD+ Complete is the only 4-in-1 liposomal NAD+ booster. Each one utilizes different pathways to maximize uptake in the body. 

Shop NAD+ Complete
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Minimize NAD+ Consuming CD38

Energizer AM is a powerful combination of anti-aging molecules that increase ATP to power your cells, activate sirtuins, and reduce CD38 which consumes NAD+.

Liposomal: Hesperedin ▸ Trans-Resveratrol ▸ CoQ10 ▸Green Tea

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Decrease Systemic Inflammation

Shield is formulated to reduce systemic inflammation which consumes NAD+, delay cellular senescence, and increase levels of NAMPT which cells use to create NAD+.

Liposomal: Vitamin C  ▸ CaAKG ▸ P.E.A ▸ HLA

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Destroy Senescent Cells

Senolytique is designed to eliminate senescent cells that increase inflammation and consume NAD+, along with AMPK activators that increase NAD+ production inside cells throughout the body.

Liposomal: Fisetin ▸ Quercetin ▸ Spermidine

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Testimonials from our Happy,Healthy Community

NAD+ Complete, Shield
“I’m a committed bio-hacker with strong goals towards longevity. NAD+ maintenance is high on my list. I recommend this protocol to people every chance I get.”

- John Shoffner

J2 Racer – Age 52

Renue Blue Skin Serum
“As a Triathlete who spends time outdoors… I still have supple and youthful looking skin. I use the serum twice a day, even when I travel.”

Tenchi So

Competitive Triathlete - Age 40

Pure Powder, Skin & Body Essentials
“I have been taking Pure Powder for about two years, and it feels like a boost of energy every time. I notice a difference in my yoga practice and strength training when I take it, my body recovers faster. This is me at 39, and I feel like I have the energy of an 18 year old!”

Alexia B

Professional Athlete - Age 39

Formulation Process

Gold standard testing. Uncompromised quality.

Certified Labs

Our products are tested in ISO-Certified & cGMP certified labs for ultimate quality, purity and potency.

Testing

We use pharmaceutical-grade testing procedures & our products have to pass through 4 rounds of testing.

Ingredients

All of our products are non-GMO and 100% free from preservatives, artificial colors, flavors and sweeteners.

Science

Science, research & innovation are a top priority. Pioneering bioavailable longevity products is our speciality.

Transparency

We believe in 100% transparency and delivering an exceptional customer experience is our goal.