NAD+ Complete

The comprehensive, 4-in-1 NAD+ booster, featuring NMN, NR, trigonelline, and NAD+ itself, all in a liposomal delivery system for slower release.

Healthy Aging Cellular Energy 4-in-1 Liposomal Delivery
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NAD+ Complete bottle with text increase NAD levels
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Daane Labs Certificate of Analysis with test results and signatures.
NAD+ Complete - Image 8
Summit Certificate of Analysis document with laboratory results.
A white cylindrical supplement bottle labeled 'BENUE NAD+ COMPLETE' on a plain white background.
Promotional graphic for Brenue NAD+ Complete showing the old and new bottle packaging with a central comparison table of ingredient dosages. The image features large dark blue headline text reading 'NEW FORMULA, NEW PACKAGING' on a clean white background.
NAD+ Complete bottle with text increase NAD levels
A white cylindrical supplement bottle labeled 'NAD+ COMPLETE' by Renue Labs, shown on a dark reflective studio background.
A white plastic bottle of UPNMD Complexe dietary supplement facts label, shown on a dark blue reflective background.
A white plastic supplement bottle shown from the back, featuring a detailed black and gray 'Suggested Use' label with text, a QR code, and a barcode, set against a dark blue reflective background.
A dark promotional graphic with the headline 'Live Better, Longer' and several lines of white text about third-party testing and ingredients. The Renue By Science logo and tagline appear near the bottom on a dark blue gradient background.
An informational graphic with the heading 'What to Know' in white text over a dark blue background, followed by several paragraphs of white explanatory text about NAD+ support forms and trigonelline.
Supplement facts label with detailed nutritional information on a dark background
Diagram titled 'Protected From Bottle to Bloodstream' with various claims about product purity and quality on a light gray background.
White capsules arranged in a pile on a dark reflective surface, with white text above describing lipidosomal delivery and NAD+ precursor support. A small 'PATHWAY: BOOST' label appears in the bottom right corner.
Four hikers ascend a mountain ridge with snow-covered peaks in the background. A white supplement tub labeled HIGH COMPLETE appears in the lower left, with the text 'The all-in-one approach to cellular energy.
Certificate of Analysis for a dietary supplement with metal content testing results.
Daane Labs Certificate of Analysis with test results and signatures.
NAD+ Complete - Image 8
Summit Certificate of Analysis document with laboratory results.

NAD+ Complete

The comprehensive, 4-in-1 NAD+ booster, featuring NMN, NR, trigonelline, and NAD+ itself, all in a liposomal delivery system for slower release.

Healthy Aging Cellular Energy 4-in-1 Liposomal Delivery
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View Batch Numbers and Certificates of Analysis (COAs)
What is NAD+ Complete?

NAD+ is a compound that's vital to life as we know it, used by every living cell in hundreds of biochemical functions. Stress and wear-and-tear on your body over time can deplete your NAD+ supply, and ultimately affect your overall health and well-being.

Some people swear by one NAD+ booster. Some companies want you to believe one is best. NAD+ Complete eliminates having to choose, with a 4-in-1 formula incorporating four studied NAD+ boosters—NMN, NR, trigonelline, and NAD+ itself—into one liposomal formula that helps protect the active ingredients through digestion to provide a more sustained release over time.

Use it consistently on its own to fuel cellular energy production, repair and recovery processes, and the resilience to help you stand up to the stressors of modern life. Or take it alongside your go-to NAD+ booster for added coverage and timed release.

Ingredients & Supplement Facts

Active Ingredients:

  • NMN (nicotinamide mononucleotide): 310mg
  • NAD+ (nicotinamide adenine dinucleotide): 160mg
  • NR (nicotinamide riboside): 100mg
  • Trigonelline: 70mg

Inactive Ingredients:

  • Vegetable Cellulose (capsule)
  • Sunflower Lecithin
  • Rice Flour
  • Microcrystalline Cellulose
Batch Numbers & Certificates of Analysis (COAs)

Every batch of supplements we make is independently tested in U.S. laboratories for purity, potency, and quality.

Why Batch Numbers Matter
View All Third-Party Tests

Why Batch Numbers Matter

Most companies test a raw ingredient sample and use the report as proof of quality, but never test a finished product. So you have no idea what they actually put in the bottle.

Without a batch number that clearly corresponds to a Certificate of Analysis, you have no idea what you are actually taking.

Renue by Science is one of very few companies that publishes a test report with a batch number, so you know the exact product you receive is backed by a third-party quality guarantee.

How to Find Your Batch Number:

The batch number is located on the bottom of your product container, indicated by "BN." This number will also be on the Certificates of Analysis that correspond to the batch you received.

Top-down view of a white cosmetic jar lid showing printed black text with batch number and expiration date, on a light blue background.

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Clinical Trial: Evaluating the Efficacy of Liposomal NMN

A double-blind, placebo-controlled clinical trial was conducted with 15 healthy men aged 40 and older to measure the effects of NMN supplementation. Participants were randomly assigned to one of three groups (5 per group) and took their assigned supplement daily after breakfast for four weeks.

  • Placebo Group: Maltodextrin (4g/day)
  • Standard NMN Group: Non-liposomal NMN (350 mg/day)
  • Liposomal NMN Group: Liposomal NMN (350 mg/day)
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Blood NAD+ levels were measured at four time points:

1. Before supplementation (baseline)
2. One hour after the first dose
3. After four weeks of daily supplementation
4. Four weeks after stopping supplementation

This study design allowed researchers to assess not just how effectively each form of NMN raised NAD+ levels, but also how long those effects persisted after supplementation ended.

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Liposomal NMN Increased Blood NAD+ Levels By 84%

After four weeks of supplementation, the Liposomal NMN Group exhibited an 84% increase in blood NAD+ levels, rising from 28.6 µM (baseline) to 52.5 µM.

Although NAD+ levels declined four weeks after participants stopped supplementation, they remained elevated at 36 µM compared to the baseline of 28.6 µM.

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Encapsulated NMN Boosted NAD+ More Effectively Than Standard NMN

Among all groups, Liposomal NMN produced the greatest increase in NAD+ levels after four weeks, outperforming both Standard NMN and placebo.

Learn more about the study here

NAD+ Complete

NAD+ Complete
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NAD+


This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

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NMN


This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

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NR


This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

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Trigonelline


Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Liposomes Increase Bioavailability

With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.

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For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.

With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.

Hence the study below shows it is about 10x more bioavailable.

Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.

Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.

NAD+ Complete

NAD+ Complete

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

NAD+ Complete COA 26feb

NAD+ Complete COA 26feb

Open Certification
Lipo NAD complete heavy metals 26feb

Lipo NAD complete heavy metals 26feb

Open Certification
NAD+ Complete COA 03-26

NAD+ Complete COA 03-26

Open Certification

Frequently Asked Questions

LIPOSOMAL DELIVERY

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.

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4.6
Rated 4.6 out of 5 stars
Based on 254 reviews
Total 5 star reviews: 200
Total 4 star reviews: 18
Total 3 star reviews: 22
Total 2 star reviews: 6
Total 1 star reviews: 8
86%would recommend this product
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254 reviews
  • AC
    Ashley C.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    I am in love with this brand

    I love the NAD complete. I noticed a huge difference. I even have my whole entire family by the NAD complete. I love to pair it with the Senolytique

    Was this helpful?
  • DN
    Dayna N.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Love the new NMN packaging

    I wanted to mention the new packaging of lip NMn because it’s much easier to distinguish from the old bottle and from NAD Complete, which I really appreciate since the capsules look almost identical. I’ve also found it easy to take and haven’t had any stomach upset or other issues with it

    Was this helpful?
  • AA Profile picture for Adam A.
    Adam A.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Great product for longevity

    Have taken nmn and nad plus for over 5 year and feel great. Excellent addition to my longevity routine.

    Was this helpful?
  • RL
    Ralph L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Great Boost

    I’ve been taking Pure NMN with great results but now that I’ve added Lipo Nad+ Complete my energy had gone way up. I expected a boost in my cardio but I wasn’t expecting the boost in strength.

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  • PB Profile picture for Pedro B.
    Pedro B.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    NAD+ Complete reigns supreme

    Nothing comes close to NAD+ Complete in terms of comprehensive NAD Pathways longevity supplementation. All precursors are included for most muscle groups, tissues and organ types: NMN, NR, NAD+ direct and Trigonelline. Pair that with unmatched purity, quality and near zero toxicity, and you have the absolute NAD+ king of supplements. If you need the ultimate proof, look at the delivery methods across all of their supplement product range - it's either liposomal or sublingual delivery for optimal absorption and bioavailability. I rest my case.

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