Spermidine has been studied for a range of health-protective effects that promote healthy aging and longevity. In over 107 recent studies and counting, scientists have shed light on Spermidine’s powerful anti-aging benefits.
What is Spermidine?
Spermidine is a naturally occurring molecule that is vital to cell function and survival. It’s part of a group of molecules called polyamines. Declining polyamine levels are associated with inflammation-driven aging.
“Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms.” ⑴
Spermidine Induces Autophagy and Reduces Inflammation
Spermidine’s main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body.
Normally, the process of autophagy is induced by an extended period of fasting. However, it can also be induced by compounds like Spermidine, which mimic the anti-aging benefits of caloric restriction.
“A defective autophagy mechanism and a lack of spermidine are highly correlated with reduced life spans, chronic stress, and acute inflammation.” ⑵
Inflammation Is A Major Consumer of NAD+
Chronic inflammation is a risk factor for a wide range of age-related diseases and it’s a major consumer of NAD+. In order to restore your NAD+ pool, minimizing inflammation is vital.

Spermidine Lowers Systemic Inflammation
When removing toxic proteins and damaged cells from the body, more energy is available for the regeneration of healthy cells and results in lowered inflammation.
“Aging has been characterized by a chronic inflammation profile that leads to chronic damage to cells and is associated with many age-associated diseases.” ⑶
Spermidine’s Potential Impact On Aging
According to Dr. David Sinclair, professor of genetics at Harvard and one of the leading longevity scientists, Spermidine can reduce disease and lower bioage by 5.7 years.
“Spermidine, a tiny molecule from wheat germ, protects the heart and extends the lifespan of mice, even when given mid-life. In people, increased consumption is associated with fewer diseases & a 5.7-year age reduction.” – David A. Sinclair ⑷
Liposomal Spermidine
Although a powerful compound, Spermidine is well known for having poor bioavailability. Lipo Spermidine features our proprietary, powder-based liposomes that protect & carry the Spermidine into the bloodstream for increased absorption and targeted systemic delivery. Learn more about bioavailability of liposomes.

Powdered Liposome under Electron Microscope