Spermidine has been studied for a range of health-protective effects that promote healthy aging and longevity. In over 107 recent studies and counting, scientists have shed light on Spermidine’s powerful anti-aging benefits.
What is Spermidine?
Spermidine is a naturally occurring molecule that is vital to cell function and survival. It’s part of a group of molecules called polyamines. Declining polyamine levels are associated with inflammation-driven aging.
“Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms.” ⑴
Spermidine Induces Autophagy and Reduces Inflammation
Spermidine’s main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body.
Normally, the process of autophagy is induced by an extended period of fasting. However, it can also be induced by compounds like Spermidine, which mimic the anti-aging benefits of caloric restriction.
“A defective autophagy mechanism and a lack of spermidine are highly correlated with reduced life spans, chronic stress, and acute inflammation.” ⑵
Inflammation Is A Major Consumer of NAD+
Chronic inflammation is a risk factor for a wide range of age-related diseases and it’s a major consumer of NAD+. In order to restore your NAD+ pool, minimizing inflammation is vital.
Spermidine Lowers Systemic Inflammation
When removing toxic proteins and damaged cells from the body, more energy is available for the regeneration of healthy cells and results in lowered inflammation.
“Aging has been characterized by a chronic inflammation profile that leads to chronic damage to cells and is associated with many age-associated diseases.” ⑶
Spermidine’s Potential Impact On Aging
According to Dr. David Sinclair, professor of genetics at Harvard and one of the leading longevity scientists, Spermidine can reduce disease and lower bioage by 5.7 years.
“Spermidine, a tiny molecule from wheat germ, protects the heart and extends the lifespan of mice, even when given mid-life. In people, increased consumption is associated with fewer diseases & a 5.7-year age reduction.” – David A. Sinclair ⑷
Liposomal Spermidine
Although a powerful compound, Spermidine is well known for having poor bioavailability. Lipo Spermidine features our proprietary, powder-based liposomes that protect & carry the Spermidine into the bloodstream for increased absorption and targeted systemic delivery. Learn more about bioavailability of liposomes.
Powdered Liposome under Electron Microscope
Testing
About Liposomes
Liposomes protect ingredients through the GI tract, merging their contents into cells to improve the biodistribution of compounds.
Liposomes Demonstration
Why Liposomes
Bioavailability Issues
Solves the Bioavailibility Problem
Targeted Delivery
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3
Advanced Absorption
Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4Biocompatibility
Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5Masking
Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6Crosses the Blood Brain Barrier
Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7Nanoscale Power
This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8What are Liposomes made of?
What does phosphatidylcholine do?
Phosphatidylcholine is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10
How do Liposomes work?
Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.References
1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave
Key Advantages of Liposomal Delivery:
- Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
- Optimizes both hydrophilic and hydrophobic, unstable compounds.
- Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
- Provides a larger nutrient payload per particle.
- Offers higher bioavailability and absorption compared to conventional capsules.
- Increases increase peak plasma concentration.
Liposome Research
RESEARCH ON LIPOSOMES FOR INCREASED BIOAVAILABILITY
Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2
Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3
WATER SOLUBILITY
Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.
Liposomal Fisetin 1.6 to 27x More Bioavailable
This study in mice found a 2.7-fold increase (in Cmax) with Liposomal Fisetin, with a dose 10 times lower than that of the free fisetin when given by IP.
With IV, the Cmax of liposomal fisetin was 10, vs 6 for free fisetin.
Liposomal Vitamin B-12 Formulas 3-5x More Bioavailable Than Tablet.
This study compared five formulations for bioavailabilty in humans over 6 hours.A standard table (iii) was compared against an emulsion (ii), a chewabletablet (iv), an oral spray comprised of larger liposomes (v) and an oral spray comprised of very small (20 nanometer) liposomes.
- (i) Nanocelle 1000ug -28% - A nano liposomal formulation of B12sublingual spray with an average particle size of about 20 nm
(ii) Emulsion 1000ug - 10% -An emulsion formulation of B12 sublingual
(iii) Tablet 1000ug - 5% - A standard tablet formulation of B12 that is absorbed through the gastrointestinal tract.
(iv) Chewable 5000ug - 27% - A dissolvabletablet of B12 that is absorbed through the sublingual mucosa
(v) Liposome 1000ug - 14% - A liposome oral spray of B12 with particle sizes of approximately 100 nm.
The chewable showed similar increase as nano liposomal, but a 5x higher dosage was used.
The standard liposomal product was 3x more bioavailable than tablet.
The nano liposomal spray exhibited sustained release with more than 5x increased bioavailability over standard tablets.
Read moreLiposomal Berberine Increases Circulation Time 23-46x
Preparation, Pharmacokinetics and Tumour-Suppressive Activity of Berberine Liposomes (Zheng, 2017)
Administration of standard Liposomal Berberine increased retention time in circulation from .42 to 10 hours. Use of PEG modified Liposomes further increased retention to to 14 hours.
Administration of Berberine solution injection is hindered by unsatisfactory pharmacokinetics and, more importantly, the risk of lethal cardiovascular adverse reactions due to rapid uptake into heart and lung. This study validated common and long-circulating liposomes as safe and effective method for sustained release of Berberine.
Read moreLiposomal Curcumin & Resveratrol Capsules 10-20x More Bioavailable in Circulation and Prostate Tissue vs Standard Capsules
Liposome capsules of resveratrol and curcumin may inhibit prostate problems by increasing their bioavailability synergistically.
In this study, we determined the bioavailability of liposome encapsulated curcumin and resveratrol, individually and in combination and evaluated the inhibitory effects of these agents against prostate growth and progression.
Serum and prostate tissue samples harvested at different time points of 30 min to12 hr with plain liposome (0.1%), curcumin (50 mg/kg/bw), lipo-curcumin (50 mg/kg/bw),lipo-resveratrol (50 mg/kg/bw) and lipo-curcumin administered with lipo-resveratrol (25 mg/kg/bw for each).
figure a - Levels of curcumin and resveratrol recorded in the serum.
figure b - Levels of curcumin and resveratrol recorded in the prostate.
figure d - Quantification of tumor growth inhibition. Total number of adenocarcinomas observed under 10 high-power fields of control vs. treatment groups.
Read more
Liposomal Glutathione More Effective
Clinical research aiming to improve glutathione concentration requires sufficient glutathione absorption and delivery.Researchers turn to liposomal glutathione to achieve sustained bioavailability.
Results from two recent studies showed that liposomal nanoformulation absorption is more effective for raising blood glutathione levels in humans than non-liposomal glutathione. 1
Both studies report a very rapid decline in bioavailability of non-liposome-encapsulated glutathione compared to liposomal glutathione.
Liposome Encapsulated Glutathione Elevates Body Stores
The results of a recent study demonstrated increased body stores of Glutathione (GSH) after oral administration of Liposomal GSH humans. 2
Since GSH is subject to destruction in the acid environment of the stomach, researchers tested that oral liposomal GSH might be an effective means of GSH delivery in vivo.
Finally, liposomal GSH was highly tolerated and its administration was not associated with any signs of adverse effects. 3
The results from this study provide support for the potential use of oral liposomal Glutathione as an intervention strategy for enhancing tissue Glutathione levels for use in disease therapy or prevention.
Liposomal Glutathione effects were often greater that previously observed for non-liposomal Glutathione . 4
Read More
Enhanced Efficacy of Apigenin Liposomes
A recent study focusing on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects.
"Apigenin liposomes bypass the hurdles posed by apigenin as a chemotherapeutic due to its high hydrophobicity. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics."
Liposomal Quercetin:Prolonged Circulation Time in Vivo
New research using Quercetin liposomes demonstrates higher quercetin concentrations in plasma than non-encapsulated quercetin and prolonged circulations time in the blood.
"The effect of quercetin liposomes was stronger than quercetin alone. This formulation provides characteristics such as high drug encapsulation ratio, low in vitro release rate and slow drug clearance and prolonged circulation time in vivo. This provides an alternative solubilization vehicle for administration of quercetin."
Liposomal Nanoparticles Improve the Solubility and Bioavailability of Quercetin in Liver
Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. A 2020 study on the protective and therapeutic effects of nanoliposomal quercetin found liposomal quercetin could effectively protect rats against acute liver injury and may be a new hepatoprotective and therapeutic agent for patients with liver diseases.
Fig. 1:Effect of nanoliposomal quercetin on histopathological changes in rat liver tissues. (Scale bar: 50 μm; HE staining). a Normal control; b-d hepatic-injured rats with b saline treatment; c quercetin treatment; and d nanoliposomal quercetin treatment.
"Interestingly, nanoliposomal quercetin was more effective on decreasing liver index and interstitial inflammatory infiltration of hepatic-injured rats than pure quercetin, which indicated that the protective effect of nanoliposomal quercetin in the injured liver was stronger than that of pure quercetin."
Testimonials
The feedback we receive from customers is important to us as we strive to continually exceed expectations and provide the most bioavailable, effective and affordable longevity supplements.
The following are uncompensated testimonials from some of our happy customers.
Improved Energy & Recovery
"I've been using the sublingual NMN for the past year and wouldn't do without it! From the first time I used it, to each time I use it, I can feel an uptick in energy and notice that my immune system seems to function better overall. I haven't been sick since we started using it! I originally tried NMN supplements because I had come down with a really bad flu last February (not Covid) and was having a hard time recovering. While I was sick I read Dr. David Sinclair's book, Lifespan, and decided to try using NMN. Wow, what a difference it made in my recovery! I got better so quickly after I started taking the supplements.
During my recovery, I took four of the sublingual tablets/day to boost my DNA repair mechanisms, and now for maintenance, I take the recommended 2/day. I've also tried both the LSG NMN and the SLC NMN and have found both to be equally as effective. I like switching the delivery mechanism for the NMN periodically to get the best response from my body. " - Jesse K.
Hair Darkening, Skin Improvements
"The darkening of my hair has been noticeable over the last 3 months or so. I take RBS Liposomal NMN and Fisetin amongst a range of other supplements.
The improvement to my facial skin & back of my hands is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards." - Lloyd D.
Improvements in Chronic Illness
"I have spent most of my life struggling with chronic pain and disease. I was pleased to not have any stimulating effects, but rather subtle yet very powerful changes after using nmn for only a couple of weeks. I notice deeper sleep, better recovery, and more strength during heavy lifts. I also noticed subtle mood changes, like not having that sort of blah feeling when it's dark, gray, and raining outside.
I have since tried more products by Renue by Science and have noticed benefits with each and every one. Their formulations are excellent and the quality of their products is Dependable through and through." - Rebekah F.
Energy Boost with Every Use
"I have been taking Pure NMN sublingual powder for about two years, and it feels like a boost of energy every time. I notice a difference in my yoga practice and strength training when I take it, my body recovers faster.
I also noticed that my vision exams have been the same in the last two years, which was never the case before. I don't know if it's related, but I would attribute it to the supplement. This is me at 39, and I feel like I have the energy of an 18 year old!" - Alexia B.
Why Us
ABOUT RENUE BY SCIENCE
As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and Facebook Group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price. Our contributions and constant objectives are:
- Moving science forward
- Driving prices down
- Setting quality standards for assurance
- Customer service equal to none
MOVING THE SCIENCE FORWARD
We constantly strive to improve the effectiveness of our products. So we experiment a lot. We have made great strides improving the bioavailability of NMN and NAD+ products, and enjoy a great reputation among our fast growing customer base as a result.
Sublingual NMN Powder – In 2016 we realized sublingual delivery of NMN is a much more efficient delivery method, so we stopped selling capsules and engineered an NMN powder specifically designed for stability and absorption when taken sublingually. It was an immediate success, as most users can feel a rush of energy, far different than taking a capsule.
Sublingual NMN and NAD+ Tablets – After the success of our NMN Powder, we partnered with the leading pharmaceutical sublingual products formulator to create the first NMN tablets that work similar to the powder in a more convenient form.
NAD+ Nasal Spray – Delivery to the mucosal membranes to rapidly cross the blood brain barrier for a much different effect than sublingual delivery.
Liposomal NMN, NAD+ and NR - A liposome is a tiny bubble made out of the same material as a cell membrane, and are used to protect a supplement through the digestive system and deliver intact to the bloodstream. Liposomal Sublingual Gel™ (LSG) is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.
Renue Skin Care Products with Liposomal NAD+, NMN, and NR - Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)
Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state.
We pioneered ALL these advances in NAD+ products in 4 years, with many more coming in 2021, so stay tuned!
DRIVING THE PRICE DOWN
In 2015 when we began producing our own brand of NMN capsules, there were few manufacturers of raw material and the price was exorbitant.
We believed in the future of NMN, so made the leap and began selling at a break-even prices that were about 1/2 what others were charging, to help spur the markets.
Others were forced to follow our lead and lowered their price almost as low as ours.
We have continued with this model for 5 years now – constantly increasing the size of our orders, and seeing the manufacturing costs drop as more manufacturers see the growing market and learn how to produce the quality product we require.
We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers.
SETTING NEW STANDARDS FOR QUALITY
When we started selling NMN on Amazon in 2016, no-one was testing the purity of their product and displaying the proof. Since it is an expensive product and there is no regulatory agency to insure quality, we decided to do so ourselves, and were the first to always post 3rd party test results.
Not only do we test the raw material, but we post test reports for each batch of finished product, as it is simple for a company to just sent a sample off for testing, post that report, but not use any NMN in the bottle
A few have followed our lead now, but many others sell absolute garbage. It is quite easy for a brand new company to pop up and slap a label on some worthless powder, buy some fake reviews on Amazon, and sell bottles to unwitting customers. We had several tested and exposed some of the scammers, but with all the money they can make ripping people off, we couldn't battle all the new brands popping up every week, so left Amazon entirely in 2019.
Dr. Brad Stanfield has taken up the battle a bit and recently tested 21 different brands. Most had less than the advertised quantity of NMN per capsule, with several having NONE. You can see his review here. Unfortunately, that too will have very little effect.
CUSTOMER SERVICE WITHOUT EQUAL
We never adopted the poor customer support standards of other online sellers and don’t outsource phone support to a 3rd party that has no idea what NMN is.
Call us and you will be surprised and the friendly, knowledgeable support.
Our Forum is a great resource for us and our customers to share information and feedback about what works and what doesn't.
We also sponsor trials where we give away free product to hundred of customers and learn more about how they like our products.
We learn from our customers.
One big difference between us and other supplement makers is, we actually talk to our customers!
That feedback has proven especially useful in the formulation of NAD+ products, and has helped us determine what works, without waiting years for the clinical research.
WHY RENUE BY SCIENCE
Whether you want to help support the company driving down prices and moving the science forward with the most effective products, or if you just want the best prices for the best quality NAD+ products, RENUE BY SCIENCE is the place.
