NAD+ with Resveratrol LIPO GEL™ is a time-released liposomal delivery system that provides superior absorption of Nicotinamide Adenine Dinucleotide (NAD+) and Resveratrol.
Our liposomal process encapsulates and delivers NAD+ and Resveratrol intracellularly in its complete form where it can be absorbed and utilized rather than being denatured in the stomach.
NAD+ supplementation has been shown to directly increase NAD+ levels through multiple pathways after increased extracellular exposure and easily cross the blood-brain barrier.
NAD+ is a critical coenzyme molecule necessary in converting nutrient food energy into cellular energy in the form of ATP. As we age, NAD+ levels naturally fall. As NAD+ levels naturally decline, mitochondrial function is impaired, resulting in fewer mitochondria surviving. This vicious cycle of mitochondrial depletion results in many of the physical symptoms of aging.
NAD+ is an essential cofactor of key enzymes responsible for longevity genes called Sirtuins. The expression of Sirtuin genes is believed to increase cellular autophagy and maintain the cells’ epigenome—ultimately resulting in healthier, functional cells. While Resveratrol is well known for Sirtuin activation, evidence indicates it does so indirectly, whereas NAD+ directly activates sirtuins to regulate the genes of aging.
Together, NAD+ and Resveratrol work synergistically to activate Sirtuins that repair damaged DNA, boost stress resistance, reduce inflammation and promote healthy aging.
NAD+ w/ Resveratrol LIPO GEL™ offers advanced support for:
- Neuroprotection and long-term brain health
- Regulating homocysteine metabolism
- Activating Sirtuin function
- Restoring overall NAD+ Levels
- Clearing senescent cells
NAD+ products have very poor bioavailability unless a delivery method is used that can protect the ingredient from digestion. When taken in regular capsules, less than 10% of NMN or NR make it to the bloodstream intact.
Here we compare each of these, highlighting their unique strengths to help you decide which product is right for you. See all products here.
* These assessments are relative. For example, ALL our products provide much greater bioavailability than standard capsules (which we do not offer), but we highlight liposomal delivery as it is more bioavailable than sublingual. All forms get a checkmark for "Improved energy" as they are nearly equal.
Convenience/Portability - This is ideal for those who want the ability to take NMN with them throughout the day. Our sublingual tablets, LIPO capsules, and nasal spray are ideal for those who are on the go and who like to take NMN at different intervals throughout the day.
Fast Acting - If fast acting is important to you, then we recommend our sublingual powder, tablets, or nasal spray as they bypass digestion. They can provide rapid absorption and reach systemic circulation for a noticable effect in minutes. So whether it's before a quick workout or you need to quickly focus on mental tasks, these products can give you a quick boost when you need it most.
Long Lasting - LIPO NMN lasts longer in the body than our other NMN products. Liposomes protect the active ingredients from digestion and release slowly in the bloodstream up to 24 hours.
Fastest Cognitive Effect- The sublingual powder has a very fast effect on physical energy, but the intranasal spray has a much stronger impact on improved cognition (the relief of "brain fog").
Improved Energy- Sublingual delivery is much faster acting and the energy boost is more quickly noticed, but the most common report from users of all NAD+ boosters is increased energy.
Easiest to Take - Some people have trouble swallowing pills or applying powder under the tongue. For those people, LSG NMN is easier because it comes in an easy to apply liquid gel.
Best Bioavailability - Approximately 30% of NMN taken sublingually gets absorbed directly into the bloodstream, while the rest passes through the GI tract and gets broken down into less effective nicotinamide. However liposomal delivery avoids degradation in the GI tract entirely, meaning far more NMN is delivered to the tissues intact.
Best Cost per Milligram - The NMN product with the best price is our sublingual powder as there is very little added cost for processing. Tablets are next. Manufacturing of Liposomes takes the most time and expensive machinery, so cost the most per Milligram.
Best Overall Value - The best overall value is the product which is best in price combined with best bioavailability. Bioavailability is how much of the product actually makes it to the cells intact. For example, our LIPO capsules cost more per milligram to manufacture, but are 3 to 5 times more bioavailable than sublingual products, so are much more cost effective.
Best Use Practice:
The pump mechanism is loaded. It may take 10-20 pumps to prime before first use.
Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when finished.
If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible.