Coenzyme Q10 and NAD+
CoQ10, also known as Coenzyme Q10, is a powerful antioxidant that protects and supports proper mitochondrial health. It is a well-known free radical scavenger for mitochondrial and lipid membranes. In addition to its antioxidant properties, it is directly involved in the electron transport chain reaction that leads to the production of ATP. (Source)
NAD+ also plays a critical role in the electron transport chain. NAD+ functions as the primary electron donor in the reaction, also known as oxidative phosphorylation, and is the main initiator of that reaction. The outcome of oxidative phosphorylation is the production of the molecule ATP. This process is severely disturbed in mitochondrial-associated disorders, chronic fatigue conditions, and inflammatory diseases which are directly correlated with decreased NAD+ levels.
Why Checking Your Blood Level of Coenzyme Q10 is Critical
When it comes to mitochondrial support, NAD+ and CoQ10 are inextricably linked. Together, their protective and energy-producing capacities support optimal mitochondrial health in every cell of the body, especially the brain. When CoQ10 levels in the body are low, proper NAD+ function is compromised.
This test measures blood levels of the antioxidant CoQ10, a coenzyme that is made in the body and is needed for the production of energy by nearly all cells.
What Decreases CoQ10?
CoQ10 and Inflammation
CoQ10, by reduction of free radicals, reduces the activation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) cells and consequently reduces the release of pro-inflammatory cytokines mainly tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) . Aging-related reduced CoQ10 levels may contribute to inflammation and there is accumulating evidence of secondary anti-inflammatory effects of CoQ10 supplementation. A recent meta-analysis provided evidence that CoQ10 supplementation significantly reduced the inflammatory markers CRP (C-reactive protein), IL-6 and TNF-α . (Source)