Fisetin is a flavonoid that is a natural polyphenol and antioxidant. Found in strawberries, apples, onions, and other plants that are particularly good at getting rid of senescent or “Zombie cells,” Fisetin is among the most powerful natural senolytics ever found and has been called “The King of Senolytics”.
One of the Most Powerful Natural Senolytics
This study found Fisetin outperformed other well known senolytics.
Liposomal Fisetin – Cellular Activity
- Help Your Body Clear Senescent Cells
- Decrease Inflammation
- Activate AMPK
- Increase NAD⁺
- Increase Healthspan
One of the main reasons you age is due to cells no longer dividing as they get older. These cells become useless and start to build up in your body triggering inflammation, gradually impairing your cellular function, and increasing your risk of age-related disease.
Get Rid of “Zombie” Cells
Scientists refer to these as Senescent cells but are more commonly called “Zombie” cells. They are like little poison factories that do no useful works but instead emit cytokines, which trigger inflammation in neighbor cells.
In human trials at the prestigious Mayo Clinic, Fisetin was shown to significantly reduce the number of senescent cells in adipose tissue, thereby reducing systemic inflammation and increasing strength and joint mobility in elderly test subjects.
Decrease inflammation and CD38, Restore NAD⁺ levels
The ability of Fisetin to destroy senescent cells clears a path for NAD⁺ boosters to be much more effective by ridding the body of the toxins that create inflammation in the body, one of the main drivers of age-related diseases.
Increased inflammation leads to more CD38 that consumes NAD⁺, which leads to more age-related diseases. Removing senescent cells lowers inflammation and spares NAD⁺ from being consumed.
In this study, fisetin has also been shown to increase NAD⁺ levels through the activation of AMPK, a key modulator of energy levels and the production of ATP, needed by mitochondria.
“We found that the AMPK/mTOR signaling pathway was enhanced after fisetin treatment.” ⑴
May Extend Health and Lifespan
This study found Fisetin reduced senescent cells, and resulted in longer lifespan.
“Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.” ⑵
Our process encapsulates and delivers Fisetin intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach. Learn More About Improved Bioavailability with Liposomes.