Learn More About Liposomal Delivery
Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream.⑴ This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.
The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly improves bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body.
Finally, liposomal GSH was highly tolerated and its administration was not associated with any signs of adverse effects. 3RESEARCH ON LIPOSOMES FOR INCREASED BIOAVAILABILITY
With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.
Liposomal Green Tea Extract 10x More Bioavailable
(This is the product we use in our Lipo Green Tea)
Liposomal Fisetin 1.6 to 27x More Bioavailable
This study in mice found a 2.7-fold increase (in Cmax) with Liposomal Fisetin, with a dose 10 times lower than that of the free fisetin when given by IP.
With IV, the Cmax of liposomal fisetin was 10, vs 6 for free fisetin.
Liposomal Vitamin B-12 Formulas 3-5x More Bioavailable Than Tablet.
The chewable showed similar increase as nano liposomal, but a 5x higher dosage was used. The standard liposomal product was 3x more bioavailable than tablet.
The nano liposomal spray exhibited sustained release with more than 5x increased bioavailability over standard tablets.
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Liposomal Berberine Increases Circulation Time 23-46x
Liposomal Curcumin & Resveratrol Capsules 10-20x More Bioavailable in Circulation and Prostate Tissue vs Standard Capsules
Liposome encapsulation of curcumin and resveratrol in combination reduces prostate incidence in PTEN knockout mice.
Liposome capsules of resveratrol and curcumin may inhibit prostate problems by increasing their bioavailability synergistically.
In this study, we determined the bioavailability of liposome encapsulated curcumin and resveratrol, individually and in combination and evaluated the inhibitory effects of these agents against prostate growth and progression.
Liposomal Glutathione More Effective
Clinical research aiming to improve glutathione concentration requires sufficient glutathione absorption and delivery.Researchers turn to liposomal glutathione to achieve sustained bioavailability.
Results from two recent studies showed that liposomal nanoformulation absorption is more effective for raising blood glutathione levels in humans than non-liposomal glutathione. 1
Both studies report a very rapid decline in bioavailability of non-liposome-encapsulated glutathione compared to liposomal glutathione.
Liposome Encapsulated Glutathione Elevates Body Stores
The results of a recent study demonstrated increased body stores of Glutathione (GSH) after oral administration of Liposomal GSH humans. 2
Since GSH is subject to destruction in the acid environment of the stomach, researchers tested that oral liposomal GSH might be an effective means of GSH delivery in vivo.
Enhanced Efficacy of Apigenin Liposomes
"Apigenin liposomes bypass the hurdles posed by apigenin as a chemotherapeutic due to its high hydrophobicity. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics."
Liposomal Quercetin: Prolonged Circulation Time in Vivo
"The effect of quercetin liposomes was stronger than quercetin alone. This formulation provides characteristics such as high drug encapsulation ratio, low in vitro release rate and slow drug clearance and prolonged circulation time in vivo. This provides an alternative solubilization vehicle for administration of quercetin."
Liposomal Nanoparticles Improve the Solubility and Bioavailability of Quercetin in Liver
Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. A 2020 study on the protective and therapeutic effects of nanoliposomal quercetin found liposomal quercetin could effectively protect rats against acute liver injury and may be a new hepatoprotective and therapeutic agent for patients with liver diseases.
"Interestingly, nanoliposomal quercetin was more effective on decreasing liver index and interstitial inflammatory infiltration of hepatic-injured rats than pure quercetin, which indicated that the protective effect of nanoliposomal quercetin in the injured liver was stronger than that of pure quercetin."
"Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier systems known to date." Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first-pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages. The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished.
Liposomes protect ingredients through the GI tract, merging their contents into cells to improve the biodistribution of compounds.
IT SOLVES THE BIOAVAILABILITY PROBLEM
The aim of taking any supplement is to ensure its transport into the bloodstream. However, due to the low absorption and bioavailability rates of traditional oral capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. ⑵
BIOCOMPATIBILITY & SAFETY
For the last five decades, advancements in this field have led to numerous clinical trials on liposomes for delivery of anti-fungal, antibiotic drugs, delivery of gene medicines, anesthetics and anti-inflammatory medications.
This is an established technology, with a variety of types of liposomes being brought to market. (Source)
KEY ADVANTAGES OF LIPOSOMAL DELIVERY
- Protects against the harsh environment of the GI tract and increases oral uptake and absorption
- Provides superior stability of active ingredients, allowing for higher absorption and greater efficacy
- Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes
- Provides a larger nutrient payload per particle
- The dose is slowly released so the supplement's concentration level can stay fairly constant in the body
More Economical - Manufacturing liposomes does add cost to the finished product, however, a 2x increase in cost is vastly outweighed by the 5-20x or greater increase in effectiveness of liposomal delivery.
More Effective - Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you're taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely. Liposomes deliver much higher quantities of the target molecules to the bloodstream.
Safer - Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages. The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness.
The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished. The phospholipids in the liposomes closely resemble the structure of your cell membranes, and as a result the body recognizes them as safe and friendly substances which are biocompatible.
Our LIPO Caps™ are used in our liposomal capsule products. The process involves encapsulating nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It’s a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body. This ensures maximum bioavailability and stability, protecting the ingredients against degradation.
Our peak particle size is less than 50 nm (nanometers). This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. ⑶
We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.
LIPO Gel products are ideal for people who have trouble swallowing pills and prefer a liquid gel. Just put two pumps under the tongue and let it absorb for 30-60 seconds before swallowing.
If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible.
The liposomes are 20-40 nanometers in size, and are derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.
Powdered Liposome under Electron Microscope
