Price per gram = $4.27
30 capsules x 500mg per capsule = 15,000mg or 15 grams
Price per bottle = $64 / 15 grams = $4.27 per gram
Why NAD+ Supplementation?
Nicotinamide Adenine Dinucleotide, commonly known as NAD+, is a molecule that is found in every living cell and is a master regulator of human metabolism. It’s a molecule essential for multiple biological processes and is also used by the genes governing the aging process named SIRTUINS. Without NAD+, cells cannot survive. As we age, the levels of NAD+ are reducing, something that affects mitochondrial function, energy production and as a result, a plethora of vital cellular functions.
NAD+ boosters are one of the most promising anti-ageing breakthroughs from scientific research so far.
The Scientific Background
NAD was discovered over a hundred years ago by scientists studying fermentation. Recently it has been hailed as a super-centenarian molecule. This is because its role in the biological process of ageing is being recognized. NAD levels have been shown to decline during chronological ageing and this decline is both a consequence of the ageing process and also a contributor to the development of age-related cellular dysfunction.
NAD+ plays a vital role in cellular health, metabolic and neuro-protection plus circadian rhythms which can all contribute to greater longevity. There are reasons why so many people are keen to boost their NAD+ levels.
A decrease in NAD+ can lead to several harmful outcomes including:
· Increased risk of sunburn and skin cancer
· Cell suffocation (Hypoxia)
· Accelerated cardiovascular disease
· Decreased metabolism
· Impaired brain function
What is Nicotinamide Mononucleotide (NMN)?
As our cells can’t absorb NAD+ directly we need to use a “precursor”, which is a molecule that converts into NAD+. One of the precursors for NAD+ is beta nicotinamide mononucleotide or NMN. NMN is a Vitamin B3 (niacin) derivative. Put simply, NMN increases NAD+, activates the longevity genes SIRTUINS and suppresses ageing.
NMN has gained a lot of attention recently, especially after the release of longevity scientist, David Sinclair’s book Lifespan. In his book, the scientist discusses his research examining NMN, particularly in mice.
Can I get NMN from food?
NMN can be found naturally in foods such as broccoli, cabbage, avocados and tomatoes. However, as the concentrations are less than 1 mg per kg of food you would need to consume about 1kg of broccoli to get about 1mg of NMN! Therefore, you need a supplement to get an optimum level of NMN.
12 MONTHS STUDY IN MICE
INCREASED HEALTHSPAN IN MICE
In a study with mice, NMN was added to their drinking water. According to the authors “We found that a 12 month-long NMN administration:
1) is well-tolerated without any obvious deleterious effects
2) suppresses age-associated body weight gain
3) enhances food intake, oxygen consumption, energy expenditure, and physical activity
4) improves insulin sensitivity and plasma lipid profile, independent of its effect on body weight
5) improves eye function, bone density, and myeloid-lymphoid composition.
NMN administration was also able to prevent age-associated gene expression changes in a tissue-dependent manner and enhance mitochondrial respiratory capability in skeletal muscle.”