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Research about Improved Bioavailability with Liposomes
LIPO Berberine™ is a sustained-released liposomal delivery system that provides superior absorption of Berberine in easy-to-swallow capsules.
Our process encapsulates and delivers Berberine intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.
LIPO Berberine™ offers advanced support for:
▸ Metabolic function and clearing senescent cells
▸ Weight Management
▸ AMPK activation
▸ Blood sugar and insulin metabolism
▸ Microbiome balance
Berberine affects the body at the molecular level and has a variety of functions inside cells. One of the main functions is activating an important enzyme called AMPK, which regulates metabolism.
Berberine is one of the most promising interventions to slow the accumulation of senescent cells by inducing autophagy. Autophagy is an evolutionary self-preservation mechanism through which the body can remove dysfunctional cells and toxic proteins responsible for many age-related chronic diseases and recycle parts of them toward cellular repair and cleaning.
Berberine’s benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome. It has also been shown to increase NAD+ levels through its activation of the AMPK enzyme.
Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2
Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3
Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.
This study in mice found a 2.7-fold increase (in Cmax) with Liposomal Fisetin, with a dose 10 times lower than that of the free fisetin when given by IP.
With IV, the Cmax of liposomal fisetin was 10, vs 6 for free fisetin.
This study compared five formulations for bioavailabilty in humans over 6 hours.A standard table (iii) was compared against an emulsion (ii), a chewabletablet (iv), an oral spray comprised of larger liposomes (v) and an oral spray comprised of very small (20 nanometer) liposomes.
(ii) Emulsion 1000ug - 10% -An emulsion formulation of B12 sublingual
(iii) Tablet 1000ug - 5% - A standard tablet formulation of B12 that is absorbed through the gastrointestinal tract.
(iv) Chewable 5000ug - 27% - A dissolvabletablet of B12 that is absorbed through the sublingual mucosa
(v) Liposome 1000ug - 14% - A liposome oral spray of B12 with particle sizes of approximately 100 nm.
The chewable showed similar increase as nano liposomal, but a 5x higher dosage was used.
The standard liposomal product was 3x more bioavailable than tablet.
The nano liposomal spray exhibited sustained release with more than 5x increased bioavailability over standard tablets.
Read more
Preparation, Pharmacokinetics and Tumour-Suppressive Activity of Berberine Liposomes (Zheng, 2017)
Administration of standard Liposomal Berberine increased retention time in circulation from .42 to 10 hours. Use of PEG modified Liposomes further increased retention to to 14 hours.
Administration of Berberine solution injection is hindered by unsatisfactory pharmacokinetics and, more importantly, the risk of lethal cardiovascular adverse reactions due to rapid uptake into heart and lung. This study validated common and long-circulating liposomes as safe and effective method for sustained release of Berberine.
Read moreLiposome capsules of resveratrol and curcumin may inhibit prostate problems by increasing their bioavailability synergistically.
In this study, we determined the bioavailability of liposome encapsulated curcumin and resveratrol, individually and in combination and evaluated the inhibitory effects of these agents against prostate growth and progression.
Serum and prostate tissue samples harvested at different time points of 30 min to12 hr with plain liposome (0.1%), curcumin (50 mg/kg/bw), lipo-curcumin (50 mg/kg/bw),lipo-resveratrol (50 mg/kg/bw) and lipo-curcumin administered with lipo-resveratrol (25 mg/kg/bw for each).
figure a - Levels of curcumin and resveratrol recorded in the serum.
figure b - Levels of curcumin and resveratrol recorded in the prostate.
figure d - Quantification of tumor growth inhibition. Total number of adenocarcinomas observed under 10 high-power fields of control vs. treatment groups.
Read more
Clinical research aiming to improve glutathione concentration requires sufficient glutathione absorption and delivery.Researchers turn to liposomal glutathione to achieve sustained bioavailability.
Results from two recent studies showed that liposomal nanoformulation absorption is more effective for raising blood glutathione levels in humans than non-liposomal glutathione. 1
Both studies report a very rapid decline in bioavailability of non-liposome-encapsulated glutathione compared to liposomal glutathione.
The results of a recent study demonstrated increased body stores of Glutathione (GSH) after oral administration of Liposomal GSH humans. 2
Since GSH is subject to destruction in the acid environment of the stomach, researchers tested that oral liposomal GSH might be an effective means of GSH delivery in vivo.
Finally, liposomal GSH was highly tolerated and its administration was not associated with any signs of adverse effects. 3
The results from this study provide support for the potential use of oral liposomal Glutathione as an intervention strategy for enhancing tissue Glutathione levels for use in disease therapy or prevention.
Liposomal Glutathione effects were often greater that previously observed for non-liposomal Glutathione . 4
Read More
A recent study focusing on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects.
"Apigenin liposomes bypass the hurdles posed by apigenin as a chemotherapeutic due to its high hydrophobicity. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics."
New research using Quercetin liposomes demonstrates higher quercetin concentrations in plasma than non-encapsulated quercetin and prolonged circulations time in the blood.
"The effect of quercetin liposomes was stronger than quercetin alone. This formulation provides characteristics such as high drug encapsulation ratio, low in vitro release rate and slow drug clearance and prolonged circulation time in vivo. This provides an alternative solubilization vehicle for administration of quercetin."
Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. A 2020 study on the protective and therapeutic effects of nanoliposomal quercetin found liposomal quercetin could effectively protect rats against acute liver injury and may be a new hepatoprotective and therapeutic agent for patients with liver diseases.
Fig. 1:Effect of nanoliposomal quercetin on histopathological changes in rat liver tissues. (Scale bar: 50 μm; HE staining). a Normal control; b-d hepatic-injured rats with b saline treatment; c quercetin treatment; and d nanoliposomal quercetin treatment.
"Interestingly, nanoliposomal quercetin was more effective on decreasing liver index and interstitial inflammatory infiltration of hepatic-injured rats than pure quercetin, which indicated that the protective effect of nanoliposomal quercetin in the injured liver was stronger than that of pure quercetin."
The feedback we receive from customers is important to us as we strive to continually exceed expectations and provide the most bioavailable, effective and affordable longevity supplements.
The following are uncompensated testimonials from some of our happy customers.
"I've been using the sublingual NMN for the past year and wouldn't do without it! From the first time I used it, to each time I use it, I can feel an uptick in energy and notice that my immune system seems to function better overall. I haven't been sick since we started using it! I originally tried NMN supplements because I had come down with a really bad flu last February (not Covid) and was having a hard time recovering. While I was sick I read Dr. David Sinclair's book, Lifespan, and decided to try using NMN. Wow, what a difference it made in my recovery! I got better so quickly after I started taking the supplements.
During my recovery, I took four of the sublingual tablets/day to boost my DNA repair mechanisms, and now for maintenance, I take the recommended 2/day. I've also tried both the LSG NMN and the SLC NMN and have found both to be equally as effective. I like switching the delivery mechanism for the NMN periodically to get the best response from my body. " - Jesse K.
"The darkening of my hair has been noticeable over the last 3 months or so. I take RBS Liposomal NMN and Fisetin amongst a range of other supplements.
The improvement to my facial skin & back of my hands is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards." - Lloyd D.
"I have spent most of my life struggling with chronic pain and disease. I was pleased to not have any stimulating effects, but rather subtle yet very powerful changes after using nmn for only a couple of weeks. I notice deeper sleep, better recovery, and more strength during heavy lifts. I also noticed subtle mood changes, like not having that sort of blah feeling when it's dark, gray, and raining outside.
I have since tried more products by Renue by Science and have noticed benefits with each and every one. Their formulations are excellent and the quality of their products is Dependable through and through." - Rebekah F.
"I have been taking Pure NMN sublingual powder for about two years, and it feels like a boost of energy every time. I notice a difference in my yoga practice and strength training when I take it, my body recovers faster.
I also noticed that my vision exams have been the same in the last two years, which was never the case before. I don't know if it's related, but I would attribute it to the supplement. This is me at 39, and I feel like I have the energy of an 18 year old!" - Alexia B.
As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and Facebook Group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price. Our contributions and constant objectives are:
We constantly strive to improve the effectiveness of our products. So we experiment a lot. We have made great strides improving the bioavailability of NMN and NAD+ products, and enjoy a great reputation among our fast growing customer base as a result.
Sublingual NMN Powder – In 2016 we realized sublingual delivery of NMN is a much more efficient delivery method, so we stopped selling capsules and engineered an NMN powder specifically designed for stability and absorption when taken sublingually. It was an immediate success, as most users can feel a rush of energy, far different than taking a capsule.
Sublingual NMN and NAD+ Tablets – After the success of our NMN Powder, we partnered with the leading pharmaceutical sublingual products formulator to create the first NMN tablets that work similar to the powder in a more convenient form.
NAD+ Nasal Spray – Delivery to the mucosal membranes to rapidly cross the blood brain barrier for a much different effect than sublingual delivery.
Liposomal NMN, NAD+ and NR - A liposome is a tiny bubble made out of the same material as a cell membrane, and are used to protect a supplement through the digestive system and deliver intact to the bloodstream. Liposomal Sublingual Gel™ (LSG) is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.
Renue Skin Care Products with Liposomal NAD+, NMN, and NR - Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)
Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state.
We pioneered ALL these advances in NAD+ products in 4 years, with many more coming in 2021, so stay tuned!
In 2015 when we began producing our own brand of NMN capsules, there were few manufacturers of raw material and the price was exorbitant.
We believed in the future of NMN, so made the leap and began selling at a break-even prices that were about 1/2 what others were charging, to help spur the markets.
Others were forced to follow our lead and lowered their price almost as low as ours.
We have continued with this model for 5 years now – constantly increasing the size of our orders, and seeing the manufacturing costs drop as more manufacturers see the growing market and learn how to produce the quality product we require.
We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers.
When we started selling NMN on Amazon in 2016, no-one was testing the purity of their product and displaying the proof. Since it is an expensive product and there is no regulatory agency to insure quality, we decided to do so ourselves, and were the first to always post 3rd party test results.
Not only do we test the raw material, but we post test reports for each batch of finished product, as it is simple for a company to just sent a sample off for testing, post that report, but not use any NMN in the bottle
A few have followed our lead now, but many others sell absolute garbage. It is quite easy for a brand new company to pop up and slap a label on some worthless powder, buy some fake reviews on Amazon, and sell bottles to unwitting customers. We had several tested and exposed some of the scammers, but with all the money they can make ripping people off, we couldn't battle all the new brands popping up every week, so left Amazon entirely in 2019.
Dr. Brad Stanfield has taken up the battle a bit and recently tested 21 different brands. Most had less than the advertised quantity of NMN per capsule, with several having NONE. You can see his review here. Unfortunately, that too will have very little effect.
We never adopted the poor customer support standards of other online sellers and don’t outsource phone support to a 3rd party that has no idea what NMN is.
Call us and you will be surprised and the friendly, knowledgeable support.
Our Forum is a great resource for us and our customers to share information and feedback about what works and what doesn't.
We also sponsor trials where we give away free product to hundred of customers and learn more about how they like our products.
We learn from our customers.
One big difference between us and other supplement makers is, we actually talk to our customers!
That feedback has proven especially useful in the formulation of NAD+ products, and has helped us determine what works, without waiting years for the clinical research.
Whether you want to help support the company driving down prices and moving the science forward with the most effective products, or if you just want the best prices for the best quality NAD+ products, RENUE BY SCIENCE is the place.
