Senolytique

A liposomal blend of quercetin, fisetin, and spermidine — three compounds that support cellular renewal and the body's clearing of senescent cells.

Cellular Renewal + Repair Healthy Aging Liposomal Delivery Longevity Blend
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Total NAD+ Restoration Protocol - Image 7
A white cylindrical supplement bottle labeled SENOLYTIQUE Cellular Mineral Longevity Blend by Denue Labs, shown on a plain white background.
Promotional graphic showing two white supplement bottles side by side with the headline 'Same Formula, New Packaging.' The left bottle is labeled 'CURRENT' and reads 'SENOLYTIQUE Cellular Regression' by RENUE.
A supplement facts label with a dark blue background and white text, showing SENOLYTIQUE supplement details including Liposomal Quercetin, Liposomal Fisetin, and Liposomal Spermidine Trihydrochloride (3HCL).
An informational graphic with the heading 'What to Know' on a dark blue textured background, containing white text explaining what is, why, and how senolytique works.
A white bottle of Renue Labs Senolytique Cellular Renewal dietary supplement, set against a dark blue, moody background with a subtle reflection on the surface below.
A white plastic bottle of supplement facts facing forward, with a printed supplement facts label on the front and side. The background is a dark, moody blue-gray studio setting with a soft reflection on the surface below.
A white plastic supplement bottle shown from the back, featuring a detailed 'SUGGESTED USE' label with text, a QR code, and a barcode. The bottle is centered against a dark, moody background with a soft blue glow and a subtle reflection on the surface below.
Diagram titled 'Protected From Bottle to Bloodstream' with various claims about product purity and quality on a light gray background.
A promotional graphic with the headline 'Live Better, Longer' over a dark blue abstract background. Below is text stating that every Renue By Science product is third-party tested in ISO-certified, cGMP-certified labs, with the Renue By Science logo and the tagline 'The gold standard in longevity formulas.
An older man walks across a bridge wearing a dark zip-up hoodie, with a small white supplement bottle labeled Senolytique shown in the lower left. Text on the image describes the product ingredients and benefits.
White capsules arranged in a pile on a dark reflective surface with marketing text above them about inflammation, cleanup pathways, tissue repair, and liposomal protection. A small 'PATHWAY: PROTECT' label appears in the bottom right corner.
Total NAD+ Restoration Protocol - Image 7

Senolytique

A liposomal blend of quercetin, fisetin, and spermidine — three compounds that support cellular renewal and the body's clearing of senescent cells.

Cellular Renewal + Repair Healthy Aging Liposomal Delivery Longevity Blend
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View Batch Numbers and Certificates of Analysis (COAs)
What is Senolytique

As cells age, some stop dividing but don't clear out. They linger and stay active, affecting the tissue around them. Senolytics are compounds studied for their role in how the body clears these cells and recycles cellular material.†

Quercetin and fisetin are plant flavonoids studied for their role in cellular renewal. Spermidine is a compound your body produces naturally, studied for its role in the cellular recycling processes that clear out what cells no longer need. Senolytique combines all three into one longevity blend.†

Senolytique uses our proprietary liposomal technology to encapsulate the active ingredients in liposomes made of the same fats that make up cell membranes, protecting them through digestion for better absorption.

Ingredients & Supplement Facts

Active Ingredients:

  • Quercetin: 77mg
  • Fisetin: 35mg
  • Spermidine Trihydrochloride (3HCL): 3mg

Inactive Ingredients:

  • Vegetable Cellulose (capsule)
  • Sunflower Lecithin
  • Rice Flour
  • Microcrystalline Cellulose
Batch Numbers & Certificates of Analysis (COAs)

Every batch of supplements we make is independently tested in U.S. laboratories for purity, potency, and quality.

Why Batch Numbers Matter
View All Third-Party Tests

Why Batch Numbers Matter

Most companies test a raw ingredient sample and use the report as proof of quality, but never test a finished product. So you have no idea what they actually put in the bottle.

Without a batch number that clearly corresponds to a Certificate of Analysis, you have no idea what you are actually taking.

Renue by Science is one of very few companies that publishes a test report with a batch number, so you know the exact product you receive is backed by a third-party quality guarantee.

How to Find Your Batch Number:

The batch number is located on the bottom of your product container, indicated by "BN." This number will also be on the Certificates of Analysis that correspond to the batch you received.

Top-down view of a white cosmetic jar lid showing printed black text with batch number and expiration date, on a light blue background.

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Clear Out the Clutter - Support Cellular Renewal at the Root

As we age, our cells accumulate damage. Some stop dividing altogether, entering a dysfunctional, zombie-like state called senescence. These cells don’t die - they linger, releasing inflammatory signals and accelerating tissue breakdown.

Senolytique targets these troublemakers.

Formulated with liposomal quercetin, fisetin, and spermidine, this trio works together to support cellular cleanup and renewal, preserving the health of surrounding tissues and helping your body maintain its natural healthy rhythms.

This is longevity from the inside out - targeted, intelligent, and bioavailable.

What It Does For You

Targets senescent cells: helps clear damaged, non-dividing cells that drive inflammation and tissue aging

Preserves NAD⁺ levels: supports NAD⁺ availability by reducing one of its major cellular drains: senescent cell activity

Supports autophagy and cellular renewal: promotes natural self-cleaning and repair pathways at the cellular level

Reduces inflammatory burden: down regulates SASP (senescence-associated secretory phenotype) signaling

Advanced liposomal delivery: boosts absorption where standard powders fall shor

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Why Senolytics Matter

Senescent cells are a natural byproduct of stress, injury, and aging - but when your body can't clear them efficiently, they accumulate. These cells:

  • Disrupt healthy cell function
  • Promote inflammation
  • Deplete key molecules like NAD⁺
  • Interfere with tissue repair and immune regulation

Senolytics are compounds that selectively target these dysfunctional cells. By helping your body remove what no longer serves you, senolytics restore clarity and resilience across tissues.

Why This Formula Works

Fisetin

A plant flavonoid found in strawberries, apples, and persimmons, fisetin is one of the most potent natural senolytic agents identified in preclinical models. It supports:

  • Selective clearance of senescent cells
  • Modulated pro-inflammatory cytokines
  • Enhanced tissue repair and resilience

Studies suggest fisetin works synergistically with quercetin to amplify senolytic activity.

Quercetin

Widely studied for immune regulation and inflammation, quercetin also functions as a senolytic - particularly when paired with other flavonoids like fisetin. It:

  • Supports NK cell activity and immune surveillance
  • Modulates NF-κB and inflammatory signaling
  • Promotes mitochondrial health and cellular stress resistance

Spermidine

A naturally occurring polyamine found in wheat germ, soy, and aged cheese, spermidine is best known for enhancing autophagy - the body’s process of cellular self-renewal. It helps:

  • Promote cellular cleanup (autophagy)
  • Maintain mitochondrial integrity
  • Regulate gene expression tied to longevity pathways

Together, these compounds help shift your biology away from stagnation and toward regeneration.

All three of these ingredients are notoriously difficult to absorb.

  • Quercetin has <10% oral bioavailability in standard form
  • Fisetin is highly lipophilic and rapidly metabolized
  • Spermidine can degrade in the GI tract before reaching circulation

LIPO Senolytique uses dry liposomal technology to encapsulate each molecule in a protective phospholipid shell, mimicking your own cell membranes. This:

  • Increases stability
  • Enhances absorption
  • Allows gradual, targeted delivery into your bloodstream

That means more of the active compounds reach your cells - without degradation or waste.

This Formula Is for You If You're Looking To:

  • Promote healthy aging at the cellular level
  • Modulate inflammation and tissue damage from senescent cell buildup
  • Support NAD⁺ preservation as part of your longevity protocol
  • Enhance cellular autophagy and detox pathways
  • Improve resilience, clarity, and repair capacity with fewer capsules

Senolytique

Senolytique

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification

Strength and Purity Certification

Open Certification
Gold Standard Testing

Gold Standard Testing

Open Certification
Senolytique Report

Senolytique Report

Open Certification

Frequently Asked Questions

LIPOSOMAL DELIVERY

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.

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4.4
Rated 4.4 out of 5 stars
Based on 34 reviews
85%would recommend this product
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34 reviews
  • SK
    Shawn K.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    High quality product

    Renue by Science is my go to when I am looking to purchase a supplement or recommending a supplement to one of my clients. As a nurse practitioner, I am very conscious of making sure my clients get the very best.

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  • JM
    John M.
    Verified Buyer
    Rated 3 out of 5 stars
    20 hours ago
    Inhibits blood clotting!!!

    This product may work as advertised but beware all three of the components in Senolytique powerfully inhibit platelet aggregation and slows blood clotting time. Be warned especially if you have hemophilia or on blood thinners!!!!!

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  • JW
    john w.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    1 month ago
    Senolitique cellular regenerator.

    Havnt noticed much difference yet but i guess its only early days.I must say your delivery times and serviice are excellent.

    Was this helpful?
  • LF
    Lisa F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    Results

    I lost 6 ounces so far.

    Was this helpful?
  • OB
    Oksana B.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 months ago
    Good product

    I have been using this product for several years. But I do use it in complex with NAD+, Green tea, and others from this Renue. I do like their products. And I feel I can trust those products.

    Was this helpful?