NAD+ Energizer is a powerful combination of anti-aging molecules formulated to increase NAD⁺ levels, fuel your mitochondria, boost cellular energy and your body’s own natural defenses. Energizer contains Lipo Glutathione, Lipo CoQ10, Lipo Apigenin, and Lipo Resveratrol, which boost mitochondria, the cells energy source and sirtuins, the body’s self repair enzymes. Energizer also prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD⁺ stores to remain at higher, more youthful levels. Liposomal delivery greatly increases the bioavailability of each ingredient, making this a potent and effective combination product.
About Liposomal Delivery
Our Lipo products are part of a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.
Our process encapsulates and delivers our products intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.
Glutathione is a tripeptide composed of three amino acids – glycine, cysteine, and glutamic acid – and is a naturally occurring intracellular antioxidant found abundantly in nearly every cell in your body.
Commonly referred to as “the mother of all antioxidants”, Glutathione eliminates excess free radicals that cause DNA damage and increase the effects of aging. It has also been shown to be a very powerful detoxification agent.
One of the hallmarks of aging is a decline in energy metabolism in many tissues – especially liver, heart, and skeletal muscle. Tissue concentrations of coenzyme Q10 have been found to decline with age, accompanying age-related declines in energy metabolism.
Coenzyme Q10 plays a central role in mitochondrial oxidative phosphorylation and the production of adenosine triphosphate (ATP).
Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant, anti-inflammatory, antiviral, and neuroprotective properties.
Increasing Apigenin in the body has been shown to enhance cognition, stimulate the immune system, diminish oxidative stress and improve cellular detoxification.
Studies have shown that Apigenin prevents excessive loss of NAD⁺ by reducing the amount of circulating CD38, allowing NAD⁺ stores to remain at higher, more youthful levels.
Resveratrol is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.
Resveratrol provides a powerhouse of antioxidant & anti-inflammatory benefits and has been referred to by David Sinclair as the ignition to the fuel, NAD⁺.
Resveratrol is an antioxidant that works to fight free radicals, which in excessive amounts can damage DNA and promote aging. Polyphenols play a vital role in longevity and cellular health and survival by protecting the body’s tissues against oxidative stress, inflammation, and age-related illnesses.
RENUE BY SCIENCE introduces LIPO Caps™ the Gold Standard in supplement delivery systems that provides maximum nutrient absorption throughout the body and is clinically proven to enhance the bioavailability up to 6x more than liquid liposome formulations(1)
Liposomes encapsulate active ingredients in a phospholipid "bubble" to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream.
They are specialized delivery vehicles serving multiple roles in enhancing the capabilities of active ingredients.
Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
- Protects ingredients from digestion in stomach and intestines
- Greatly increased circulation time in the bloodstream (not filtered out by liver)
BENEFITS OF LIPOSOMAL DELIVERY
The increased bioavailability of Liposomal Delivery make it:
MORE ECONOMICAL - MORE BANG FOR THE BUCK
Manufacturing liposomes does add cost to the finished product, which is why their usage has been more limited for vitamins and supplement as opposed to expensive pharmaceutical drugs. However, a 2x increase in cost is vastly outweight by the 5-20x or greater increase in effectiveness of liposomal delivery.
Many people realize liposomal delivery provides more "bang for the buck", but it is clear they also enable much greater effectiveness and safety, and should be used for all products with known bioavailability problems.
MORE EFFECTIVE - HIGHER LEVELS OF SATURATION IN TARGET TISSUES
Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you're taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely. Liposomes deliver much higher quantities of the target molecules to the bloodstream.
SAFETY - MINIMIZES LIVER TOXICITY FROM EXCESSIVE DOSAGES
Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages. The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished.
POWDERED LIPOSOME NAD+ PRODUCTS
Our LIPO CAPS tm powdered liposomes technology encapsulates nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It's a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body.
This ensures maximum bioavailability and stability, protecting the bio-active ingredients against degradation.
This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. (2)
A peak particle size of less than 50 nm (nanometers) ensures the maximum bioavailability and stability.
The advanced liposomes retain the core structure of the liposomal bilayer in its powder form, which stabilizes the active ingredient and ensures maximum bioefficiency, potency and absorption.
We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.
WHY LIPOSOMAL DELIVERY IS CRITICAL
If not protected, NAD+ metabolites are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver.
TOO MUCH NAM
This can be a problem when users believe more is better and take excessive doses of standard NR or NMN capsules. Very little makes it intact through the digestive tract, liver, and bloodstream to reach the target tissue. The result is massive increases in NAM.
For example, this study gave 300 mg/kg of NR to mice and found NAM is increased 40x, while NR is not increased and exists only at trace levels
“The minute amount of dual-labeled NAD observed in muscle indicates that direct utilization of NR by the muscle does occur. However, oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN."
WHAT HAPPENS IF NAM LEVELS ARE TOO HIGH
High levels of NAM can have many negative effects such as inhibiting Sirtuins (r), which is the opposite of what you are trying to accomplish by taking NAD+ boosters. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health.
"High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM." (r)
The body does respond to try and bring NAM levels down, by attaching a Methyl group to the NAM to form MeNAM, which is then excreted. (r)
This can result in "methylation problems" where there are insufficient methyl donors that are critical for other needs and promotes age related health problems. (r)
TMG MAY HELP RESTORE METHYL GROUPS WHEN NAM LEVELS ARE TOO HIGH
As a result, it is common practice now for those taking NMN or NR to take TMG or other methyl donors. (r)
That is thought to help with the problem of excessive NAM buildup from taking high dosage NMN or NR capsules, but excess TMG can also lead to problems. (r)
LIPOSOMAL DELIVERY IS THE SOLUTION
A far better solution is to take a form of NMN or NR that protects the active ingredient from digestion to NAM.
Sublingual delivery of NMN delivers up to 30% of NMN to the bloodstream, so much less is digested to NAM and depletion of methyl groups is much less of a problem.
Liposomes are even better, as they can protect NAD+ metabolites from digestion and degradation in stomach, liver, and bloodstream.
Liposomal delivery prevents your expensive NAD+ precursors from being digested to NAM, which is a waste of money, and can actually be bad for your health.