About Defender
Defender is a unique combination of supplements formulated to reduce systemic inflammation. Decreasing systemic inflammation will minimize NAD+ consumption so that it’s available for other purposes.
We combine Lipo Berberine, Lipo CaAKG, and Lipo HLA, which work together to help prevent cellular senescence and slow the rate of age-related DNA methylation, which can help to prevent some of the many “diseases of old age”.
Defender can also elevate levels of NAD+ by increasing an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT. Defender is also formulated to promote new cartilage and bone, thereby reducing joint inflammation and pain.
About Liposomal Delivery
Our Lipo products are part of a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.
Our process encapsulates and delivers our products intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.
Lipo Berberineâ„¢
Berberine is an alkaloid found in a variety of plants. It is similar to metformin in that it can help to regulate glucose and lipid metabolism.
Berberine Found to Increase NAD+ Levels, Lower Inflammation
In a study examining the effects of Berberine on NAD+ levels, it was found that Berberine increases an important enzyme responsible for the conversion of nicotinamide to NAD+, called NAMPT.
“Berberine increases NAD+/NADH ratio through induction of NAMPT expression in C2C12 cells” (1)
As we age, we accumulate senescent cells that secrete toxins which are inflammatory. Berberine is one of the most promising interventions to slow the accumulation of senescent cells and the inflammation they secrete by inducing autophagy, the body’s way of clearing out dead and damaged cells to make way for new ones.
“Mechanistic studies exhibit that berberine induces autophagic death in ALL cells by inactivating AKT/mTORC1 signaling” (2)
Berberine’s benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome. It has also been shown to increase NAD+ levels through its activation of the AMPK enzyme.
“The beneficial effects of BBR are attributable to its effect as an AMPK activator” (3)
“Berberine has been shown to enhance AMPK activation (one of the few chemicals that does), enhance autophagy and mitigate apoptosis (cell death) induced by high glucose levels” (7)
“AMPK regulates an array of biological activities that normalize lipid, glucose, and energy imbalances” (7)
Research also indicates there is important synergy between two ingredients, berberine and CaAKG. Â AMPK is upregulated by berberine and AMPK upregulates isocitrate dehydrogenase in the Krebs cycle, which produces alpha ketoglutarate (AKG).
LIPO Berberineâ„¢ offers advanced support for:
▸  Metabolic function and clearing senescent cells
▸  Weight Management
▸  AMPK activation
▸  Blood sugar and insulin metabolism
▸ Microbiome balance
Lipo CaAKGâ„¢
Calcium-alpha-ketoglutarate (CaAKG for short) is a special form of mineral calcium used to restore calcium concentration levels in the blood back to normal.
CaAKG Slows Effects of Aging and Reduces Inflammation
CaAKG works by slowing the rate of age-related DNA methylation and reducing the inflammation caused by senescent cells: two proposed reasons why we age.
“Thus AKG may bridge cellular energy metabolism and increase amino acid availability to inhibit the secretory of inflammatory cytokines” (4)
“AKG suppresses chronic inflammation and induces secretion of IL-10 in T cells of female mice” (8)
CaAKG also contributes to metabolism, providing energy for cellular processes. It helps stimulate collagen and protein synthesis and influences age-related processes including stem cell proliferation. Increasing Calcium Alpha-Ketoglutarate in the body supports your liver and its detoxification abilities.
LIPO CaAKGâ„¢ offers advanced support for:
▸  Restoring and maintaining DNA integrity
▸  Athletic performance and recovery
▸  Managing age-related inflammation
▸  Oxidative stress
▸ Cellular Detoxification
Lipo HLAâ„¢
Hyaluronic Acid is a polysaccharide molecule, one of the main components in connective tissue and which forms a gelatinous matrix that surrounds cells.
HLA Promotes New Cell Growth and Reduces Inflammation
Hyaluronic acid (HLA) is important for promoting the growth of new cells and tissues in the joint’s cartilage and bone, thereby reducing joint inflammation and pain caused by injuries or tissue degeneration.
“Our results show that HA was able to inhibit, in a dose-related fashion, both types of inflammatory reactions” (5)
“the studies reviewed here show promising results for the use of HA in the treatment of inflammatory pathologies” (6)
HLA is also a key molecule involved in skin hydration. The natural production of Hyaluronic Acid rapidly declines by up to 50% by the time we’re 50 years old. Studies show that consuming extra hyaluronic acid boosts the body’s natural production of collagen.
LIPO HLAâ„¢ offers advanced support for:
▸ Restoring youthful skin
▸ Reducing joint pain and inflammation
▸ Healthy digestion
▸ Preserving bone mass
References:
3 – “The beneficial effects of BBR are attributable to its effect as an AMPK activator”
5 – “Hyaluronic acid modulates acute and chronic inflammation”
6 – “Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation”

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Powdered Liposome under Electron Microscope
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RENUE BY SCIENCE introduces LIPO Capsâ„¢ the Gold Standard in supplement delivery systems that provides maximum nutrient absorption throughout the body and is clinically proven to enhance the bioavailability up to 6x more than liquid liposome formulations(1)

ABOUT LIPOSOMES
Liposomes encapsulate active ingredients in a phospholipid "bubble" to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream.
They are specialized delivery vehicles serving multiple roles in enhancing the capabilities of active ingredients.
Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
- Protects ingredients from digestion in stomach and intestines
- Greatly increased circulation time in the bloodstream (not filtered out by liver)
BENEFITS OF LIPOSOMAL DELIVERY
The increased bioavailability of Liposomal Delivery make it:
MORE ECONOMICAL - MORE BANG FOR THE BUCK
Manufacturing liposomes does add cost to the finished product, which is why their usage has been more limited for vitamins and supplement as opposed to expensive pharmaceutical drugs. However, a 2x increase in cost is vastly outweight by the 5-20x or greater increase in effectiveness of liposomal delivery.
Many people realize liposomal delivery provides more "bang for the buck", but it is clear they also enable much greater effectiveness and safety, and should be used for all products with known bioavailability problems.
MORE EFFECTIVE - HIGHER LEVELS OF SATURATION IN TARGET TISSUES
Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you're taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely. Liposomes deliver much higher quantities of the target molecules to the bloodstream.
SAFETY - MINIMIZES LIVER TOXICITY FROM EXCESSIVE DOSAGES
Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages. The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished.
POWDERED LIPOSOME NAD+ PRODUCTS
Our LIPO CAPS tm powdered liposomes technology encapsulates nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It's a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body.
This ensures maximum bioavailability and stability, protecting the bio-active ingredients against degradation.
This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. (2)
A peak particle size of less than 50 nm (nanometers) ensures the maximum bioavailability and stability.
The advanced liposomes retain the core structure of the liposomal bilayer in its powder form, which stabilizes the active ingredient and ensures maximum bioefficiency, potency and absorption.
We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.
WHY LIPOSOMAL DELIVERY IS CRITICAL
If not protected, NAD+ metabolites are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver.
TOO MUCH NAM
This can be a problem when users believe more is better and take excessive doses of standard NR or NMN capsules. Very little makes it intact through the digestive tract, liver, and bloodstream to reach the target tissue. The result is massive increases in NAM.
For example, this study gave 300 mg/kg of NR to mice and found NAM is increased 40x, while NR is not increased and exists only at trace levels
“The minute amount of dual-labeled NAD observed in muscle indicates that direct utilization of NR by the muscle does occur. However, oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN."
WHAT HAPPENS IF NAM LEVELS ARE TOO HIGH
High levels of NAM can have many negative effects such as inhibiting Sirtuins (r), which is the opposite of what you are trying to accomplish by taking NAD+ boosters. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health.
"High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM." (r)
The body does respond to try and bring NAM levels down, by attaching a Methyl group to the NAM to form MeNAM, which is then excreted. (r)
This can result in "methylation problems"Â where there are insufficient methyl donors that are critical for other needs and promotes age related health problems. (r)
TMG MAY HELP RESTORE METHYL GROUPS WHEN NAM LEVELS ARE TOO HIGH
As a result, it is common practice now for those taking NMN or NR to take TMG or other methyl donors. (r)
That is thought to help with the problem of excessive NAM buildup from taking high dosage NMN or NR capsules, but excess TMG can also lead to problems. (r)
LIPOSOMAL DELIVERY IS THE SOLUTION
A far better solution is to take a form of NMN or NR that protects the active ingredient from digestion to NAM.
Sublingual delivery of NMN delivers up to 30% of NMN to the bloodstream, so much less is digested to NAM and depletion of methyl groups is much less of a problem.
Liposomes are even better, as they can protect NAD+ metabolites from digestion and degradation in stomach, liver, and bloodstream.
Liposomal delivery prevents your expensive NAD+ precursors from being digested to NAM, which is a waste of money, and can actually be bad for your health.