Defender is a unique combination of supplements formulated to reduce systemic inflammation. Decreasing systemic inflammation will minimize NAD⁺ consumption so that it’s available for other purposes.
Liposomal Berberine, CaAKG, and HLA work together to help prevent cellular senescence and slow the rate of age-related DNA methylation, which may help to prevent some of the many “diseases of old age”.
Defender may also elevate levels of NAD⁺ by increasing an important enzyme responsible for the conversion of nicotinamide to NAD,⁺ called NAMPT.
Berberine Found to Increase NAD⁺ Levels, Lower Inflammation
In a study examining the effects of Berberine on NAD⁺ levels, it was found that Berberine increases an important enzyme responsible for the conversion of nicotinamide to NAD,⁺ called NAMPT.
“Berberine increases NAD+/NADH ratio through induction of NAMPT expression in C2C12 cells.” (1)
Berberine Induces Autophagy
As you age, you accumulate senescent cells that secrete toxins which are inflammatory. Berberine is one of the most promising interventions to slow the accumulation of senescent cells and the inflammation they secrete by inducing autophagy, the body’s way of clearing out dead and damaged cells to make way for new ones.
“Mechanistic studies exhibit that berberine induces autophagic death in ALL cells by inactivating AKT/mTORC1 signaling.” (2)
It has also been shown to increase NAD⁺ levels through its activation of the AMPK enzyme.
“Berberine has been shown to enhance AMPK activation (one of the few chemicals that does), enhance autophagy and mitigate apoptosis (cell death) induced by high glucose levels.” (3)
CaAKG Slows Effects of Aging and Reduces Inflammation
CaAKG works by slowing the rate of age-related DNA methylation and reducing the inflammation caused by senescent cells: two proposed reasons why we age.
“AKG suppresses chronic inflammation and induces secretion of IL-10 in T cells of female mice.” (4)
CaAKG also contributes to metabolism, providing energy for cellular processes. It helps stimulate collagen and protein synthesis and influences age-related processes including stem cell proliferation.
HLA Promotes New Cell Growth and Reduces Inflammation
Hyaluronic acid (HLA) is important for promoting the growth of new cells and tissues in the joint’s cartilage and bone, which thereby may reduce joint inflammation caused by injuries or tissue degeneration.
“The studies reviewed here show promising results for the use of HA in the treatment of inflammatory pathologies.” (5)
About Liposomal Delivery
Our process encapsulates and delivers our products intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach. Learn More About Improved Bioavailability with Liposomes.