The absorption of the different molecules delivered through the sublingual route can be 3 to 10 times greater than oral route and is only surpassed by direct IV injection (3).
Research on sublingual delivery of NMN is not yet published, so the increased efficiency is not yet quantified.
This research published in 2018 confirms that most oral supplements of NMN and NR are digested to NAM in the GI tract or the liver.
Unlike in cell culture where NR and NMN are readily incorporated into NAD, oral administration fails to deliver NR or NMN to tissues (R)
Interestingly, we found that neither compound was able to enter the circulation intact in substantial quantities when delivered orally (R)
SUBLINGUAL CAN BE MORE BIOAVAILABLE THAN IP INJECTION !
With intraperitoneal injection, the primary route of absorption is via the mesenteric vessels, which drain into the portal vein and pass through the liver before reaching the bloodstream.
This means, IP avoids the GI tract, but is still sent directly to the Liver, where much of it is converted to NAD+. Elevated NAD+ in the liver is good, but its far better to reach the bloodstream with intact NMN.
Sublingual delivery is not filtered by the Liver and can reach systemic circulation intact, so can actually result in greater bioavailability that direct injection! Some examples are:
NAD+ can be synthesized in humans from several different molecules (precursors), thru the De Novo and Salvage Pathways.
Nampt is the rate-limiting step in the salvage process.
As we age, Nampt enzyme activity is lower, resulting in less NAM recycling, less NAD+, more disease and aging
Restoring NAD+ in the Liver does not solve NAD+ deficiency throughout the body.
In the Liver, the CD38 enzyme metabolizes NAD+ to NAM, which is excreted to the rest of the body (6).
Sublingual delivery of NMN or NAD+ directly to the bloodstream partially bypasses the liver and the Nampt bottleneck.
The feedback we receive from customers is important to us as we strive to continually exceed expectations and provide the most bioavailable, effective and affordable longevity supplements.
The following are uncompensated testimonials from some of our happy customers.
"I've been using the sublingual NMN for the past year and wouldn't do without it! From the first time I used it, to each time I use it, I can feel an uptick in energy and notice that my immune system seems to function better overall. I haven't been sick since we started using it! I originally tried NMN supplements because I had come down with a really bad flu last February (not Covid) and was having a hard time recovering. While I was sick I read Dr. David Sinclair's book, Lifespan, and decided to try using NMN. Wow, what a difference it made in my recovery! I got better so quickly after I started taking the supplements.
During my recovery, I took four of the sublingual tablets/day to boost my DNA repair mechanisms, and now for maintenance, I take the recommended 2/day. I've also tried both the LSG NMN and the SLC NMN and have found both to be equally as effective. I like switching the delivery mechanism for the NMN periodically to get the best response from my body. " - Jesse K.
"The darkening of my hair has been noticeable over the last 3 months or so. I take RBS Liposomal NMN and Fisetin amongst a range of other supplements.
The improvement to my facial skin & back of my hands is absolutely associated with the Renue applications. I had noticed it but when other people started commenting I felt that I had something more concrete to contribute. So in summary this is a remarkable result by any standards." - Lloyd D.
"I have spent most of my life struggling with chronic pain and disease. I was pleased to not have any stimulating effects, but rather subtle yet very powerful changes after using nmn for only a couple of weeks. I notice deeper sleep, better recovery, and more strength during heavy lifts. I also noticed subtle mood changes, like not having that sort of blah feeling when it's dark, gray, and raining outside.
I have since tried more products by Renue by Science and have noticed benefits with each and every one. Their formulations are excellent and the quality of their products is Dependable through and through." - Rebekah F.
"I have been taking Pure NMN sublingual powder for about two years, and it feels like a boost of energy every time. I notice a difference in my yoga practice and strength training when I take it, my body recovers faster.
I also noticed that my vision exams have been the same in the last two years, which was never the case before. I don't know if it's related, but I would attribute it to the supplement. This is me at 39, and I feel like I have the energy of an 18 year old!" - Alexia B.
"I take 125 mg before my workouts, 3-5 times a week. During resistance training I see an increased pump.
I finish with a rowing machine sprint, and taking NMN gives me a 5-10% increase in distance rowed. Very impressed with this stuff!"
"I have a form of Retinitis Pigmentosa which has been sending me blind for the last 20 years at least. I have fought it with everything I had but was losing the fight in my late 30s. It wasn’t until I started the sublingual NMN that I felt definite vision improvements after only one week."
As part of J2Racing he has 3 in-class victories in the Carrera Cup Class of the VLN in recent years.
“I’m a committed bio-hacker with strong goals toward longevity. NAD maintenance is high on my list. I recommend this protocol to people every chance I get.”
"I am the Reigning 65-69 IRONMAN World Champion, a title earned in October 2017 in
Kona, Hawaii. I am able to detect a small “lift” when I take NMN.
I require less sleep and recover faster."
"I was taking the NMN tablets for two years, but find I like the NAD+ tablets and spray better, so have switched to those. At 61, I look at least 15 years younger than others my age. Results from Teloyears were even more encouraging as they showed my telomere length to be that of a 20 year old."
"It feels like I'm putting liquid gold on my arm. That's probably the best way to describe it.
This could be what prevents some of your aging. NAD+ is the fountain of youth. We all have NAD+ in our bodies but it decreases as we get older. I highly recommend this!"
"I LOVE these products! I've definitely noticed less redness and smoother skin around my eyes and forehead. They are the only ones I'd ever use going forward because I see actual results. Most creams and serums are overly expensive and truly don't do anything. I have spent so much money on luxury facial treatments in the past and now I will not be going back. I love the Renue skin care line.”
"I still have supple and youthful looking skin. Thanks, Renue! As a Triathlete who spends time outdoors a lot for training and racing, Renue products have made my skin look young again. I still have supple and youthful looking skin, and don't have much sun spots or damage from the sun. I look like I'm still in my late 20s, even though I just turned 40 this April!”
As the industry leader and largest manufacturer of NAD+ products, we consult with a wide range of research and clinical doctors to understand the latest research and combine that with feedback from tens of thousands of customers on our forum and Facebook Group. This helps us learn so we can offer the best quality, most effective NAD+ restoration products at the absolute lowest price. Our contributions and constant objectives are:
We constantly strive to improve the effectiveness of our products. So we experiment a lot. We have made great strides improving the bioavailability of NMN and NAD+ products, and enjoy a great reputation among our fast growing customer base as a result.
Sublingual NMN Powder – In 2016 we realized sublingual delivery of NMN is a much more efficient delivery method, so we stopped selling capsules and engineered an NMN powder specifically designed for stability and absorption when taken sublingually. It was an immediate success, as most users can feel a rush of energy, far different than taking a capsule.
Sublingual NMN and NAD+ Tablets – After the success of our NMN Powder, we partnered with the leading pharmaceutical sublingual products formulator to create the first NMN tablets that work similar to the powder in a more convenient form.
NAD+ Nasal Spray – Delivery to the mucosal membranes to rapidly cross the blood brain barrier for a much different effect than sublingual delivery.
Liposomal NMN, NAD+ and NR - A liposome is a tiny bubble made out of the same material as a cell membrane, and are used to protect a supplement through the digestive system and deliver intact to the bloodstream. Liposomal Sublingual Gel™ (LSG) is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.
Renue Skin Care Products with Liposomal NAD+, NMN, and NR - Renue™ delivers the transformative power of NAD+ along with apocynin and resveratrol across the layers of the skin using breakthrough nanoliposome technology. (1)
Restoring NAD+ in the skin has shown to be effective at treating a wide range of skin disorders, returning it to a more youthful state.
We pioneered ALL these advances in NAD+ products in 4 years, with many more coming in 2021, so stay tuned!
In 2015 when we began producing our own brand of NMN capsules, there were few manufacturers of raw material and the price was exorbitant.
We believed in the future of NMN, so made the leap and began selling at a break-even prices that were about 1/2 what others were charging, to help spur the markets.
Others were forced to follow our lead and lowered their price almost as low as ours.
We have continued with this model for 5 years now – constantly increasing the size of our orders, and seeing the manufacturing costs drop as more manufacturers see the growing market and learn how to produce the quality product we require.
We’re thrilled to be able to set our retail prices around 1/3 of what they were when we started, and continuously dropping. As always, other companies are forced to lower their prices to match ours, but can’t quite do so as we our the largest buyer and get the best pricing from manufacturers.
When we started selling NMN on Amazon in 2016, no-one was testing the purity of their product and displaying the proof. Since it is an expensive product and there is no regulatory agency to insure quality, we decided to do so ourselves, and were the first to always post 3rd party test results.
Not only do we test the raw material, but we post test reports for each batch of finished product, as it is simple for a company to just sent a sample off for testing, post that report, but not use any NMN in the bottle
A few have followed our lead now, but many others sell absolute garbage. It is quite easy for a brand new company to pop up and slap a label on some worthless powder, buy some fake reviews on Amazon, and sell bottles to unwitting customers. We had several tested and exposed some of the scammers, but with all the money they can make ripping people off, we couldn't battle all the new brands popping up every week, so left Amazon entirely in 2019.
Dr. Brad Stanfield has taken up the battle a bit and recently tested 21 different brands. Most had less than the advertised quantity of NMN per capsule, with several having NONE. You can see his review here. Unfortunately, that too will have very little effect.
We never adopted the poor customer support standards of other online sellers and don’t outsource phone support to a 3rd party that has no idea what NMN is.
Call us and you will be surprised and the friendly, knowledgeable support.
Our Forum is a great resource for us and our customers to share information and feedback about what works and what doesn't.
We also sponsor trials where we give away free product to hundred of customers and learn more about how they like our products.
We learn from our customers.
One big difference between us and other supplement makers is, we actually talk to our customers!
That feedback has proven especially useful in the formulation of NAD+ products, and has helped us determine what works, without waiting years for the clinical research.
Whether you want to help support the company driving down prices and moving the science forward with the most effective products, or if you just want the best prices for the best quality NAD+ products, RENUE BY SCIENCE is the place.