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Recommended 2 Pumps

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Name: Liposomal Nasal Spray - NAD⁺ NMN NR | Enhanced Absorption
Brand: Renue Store
SKU: 850055685215
Price: 59.95 USD
Availability: InStock
Rating: 3.36 (69 reviews)

Convenient cognitive boost

$59.95 USD

Product variants

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If you’re looking for a convenient on-the-go product, our NAD+ nasal spray is the perfect complement to your main NAD+ supplements.

The NAD+ nasal spray provides targeted delivery, focusing on the brain, rather than widespread systemic circulation. It’s designed to have a stronger effect on cognition and brain fog than all other delivery methods.†

Recommended 2 Pumps

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Clinical Trial: Evaluating the Efficacy of Liposomal NMN

A double-blind, placebo-controlled clinical trial was conducted with 15 healthy men aged 40 and older to measure the effects of NMN supplementation. Participants were randomly assigned to one of three groups (5 per group) and took their assigned supplement daily after breakfast for four weeks.

Placebo Group: Maltodextrin (4g/day)
Standard NMN Group: Non-liposomal NMN (350 mg/day)
Liposomal NMN Group: Liposomal NMN (350 mg/day)

Blood NAD+ levels were measured at four time points:

1. Before supplementation (baseline)
2. One hour after the first dose
3. After four weeks of daily supplementation
4. Four weeks after stopping supplementation

This study design allowed researchers to assess not just how effectively each form of NMN raised NAD+ levels, but also how long those effects persisted after supplementation ended.

NAD+ Is Essential to Life ...but declines with age

NAD+ precursors and defenders can protect youthful NAD+ levels to maintain healthy energy, strength, and cognition.

Liposomal NMN Increased Blood NAD+ Levels By 84%

After four weeks of supplementation, the Liposomal NMN Group exhibited an 84% increase in blood NAD+ levels, rising from 28.6 µM (baseline) to 52.5 µM.

Although NAD+ levels declined four weeks after participants stopped supplementation, they remained elevated at 36 µM compared to the baseline of 28.6 µM.

Encapsulated NMN Boosted NAD+ More Effectively Than Standard NMN

Among all groups, Liposomal NMN produced the greatest increase in NAD+ levels after four weeks, outperforming both Standard NMN and placebo.

Learn More about the Study HERE

Which NAD+ Precursor Is Best?

NAD+

This central coenzyme is directly involved in redox reactions and serves as a substrate for energy production enzyme activity, including sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate cellular metabolism, DNA repair, and epigenetic modifications.

NMN

This NAD+ precursor, which is directly converted to NAD+ through the NMNAT enzyme in the Salvage Pathway, has been shown to effectively increase intracellular NAD+ levels in numerous clinical trials, thereby enhancing mitochondrial function, energy production, and the activity of NAD+-dependent enzymes.

NR

This NAD+ precursor, which is converted to NAD+ through the Preiss-Handler Pathway, has also demonstrated the ability to increase NAD+ levels in cells. It supports cellular repair mechanisms, particularly those involved in DNA damage response and oxidative stress mitigation. By buttressing NAD+ levels, NR promotes the activation of sirtuins and PARPs, which protect genomic stability and regulating cellular metabolism.

Trigonelline

Trigonelline promotes cellular NAD+ production differently than NMN or NR. This methylated form of niacin offers several advantages: exceptional stability in the bloodstream, slow release into target tissues, non-flushing, protection against stomach digestion, and direct NAD+ increase in muscle tissues.

Learn More About Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)

This allows for the ingredients to be absorbed and utilized rather than being destroyed in the stomach.

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Research

Liposomes Increase Bioavailability

With our Liposomal products, approximately 90% of the payload reaches the bloodstream intact, regardless of what the payload is.

For example, with our Liposomal Green Tea Extract around 90% of the EGCG reaches the bloodstream.

With regular Green Tea extract, around 9% of EGCG reaches the bloodstream.

Hence the study below shows it is about 10x more bioavailable.

Regular Apigenin is around 30% bioavailable, so you can expect our Liposomal Apigenin to be approximately 3x more bioavailable than regular Apigenin.

Although we don't have research on bioavailability of all our Liposomal products, below we show research that demonstrates increased bioavailability of 3 to 40x when using liposomes in some of the most popular supplements we produce.

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Frequently Asked Questions

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

When do LIPO gel products expire?

LIPO gel products are good for 2 years from the date of manufacture printed on the bottle.

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.

NAD+ spray

Burns. No idea if it's working or helping.

NAD Complete Nasal Spray

I have used this, with difficulty, for a month. Whilst I have had improved energy levels & believe it has helped, the Spray container does not work adequately, not delivering the dosage expected. There is a mechanical fault with the container, with generating a spray being very difficult.

Broken bottle

Mine showed up broken and cannot work due to the straw connected to the nasal spray being too long for the bottle so it bent and showed up cracked. Hoping I get to try this in general soon but would not want to pay this price for a broken product.

NAD

Excellent product, make feel very awake all day

Not for Me

Didn't help my joint pain, but gave me a small energy boost.

1 2 3

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Convenient cognitive boost

Clinical Trial: Evaluating the Efficacy of Liposomal NMN

NAD+ Is Essential to Life ...but declines with age

Liposomal NMN Increased Blood NAD+ Levels By 84%

Encapsulated NMN Boosted NAD+ More Effectively Than Standard NMN

Which NAD+ Precursor Is Best?

NAD+

NMN

NR

Trigonelline

Learn More About Liposomal Delivery

Liposomes are a revolutionary way of encapsulating active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of your tissues, which are reached via the bloodstream. (1)

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Liposomes Increase Bioavailability

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

Certifications

Supported by Science

Purest Ingredients

Advanced Testing

Certified Labs

Strength and Purity Certification

Gold Standard Testing

Nasal NAD+ Report

Nasal Spray with NAD⁺, NMN, NR, Trigonelline (Liposomal)

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