Research
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have been leading choices for raising NAD+ levels. Their popularity stems from the limitations of...
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have...
NR Improved Brain and Blood Vessel Health in Ad...
Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased in areas linked to memory and decision-making Participants showed modest gains in cognitive tests,...
NR Improved Brain and Blood Vessel Health in Ad...
Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased...
Safety of IV Nicotinamide Riboside at Different...
Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600 mg/kg) caused negative effects, including cardiovascular, liver, and kidney damage Increasing Doses of IV...
Safety of IV Nicotinamide Riboside at Different...
Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600...
NAD+ as a Multi-Target Therapy for Neurodegener...
Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic potential Early human trials indicate promising clinical benefits Brain delivery and individual response differences...
NAD+ as a Multi-Target Therapy for Neurodegener...
Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic...
NR Boosts Fat-Burning Activity in Obese Mice
What is Brown Fat and Why is it Important? Brown fat, or brown adipose tissue (BAT), is a special type of body fat that burns energy to produce heat -...
NR Boosts Fat-Burning Activity in Obese Mice
What is Brown Fat and Why is it Important? Brown fat, or brown adipose tissue (BAT),...
NMN Offers More Protection Than NR in Friedreic...
This study examined the potential benefits of NMN and NR in a mouse model of Friedreich’s ataxia (FRDA), a neurodegenerative disease characterized by impaired motor function and heart problems. Key...
NMN Offers More Protection Than NR in Friedreic...
This study examined the potential benefits of NMN and NR in a mouse model of Friedreich’s...
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more tolerable.”
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more...
NMN More Effective Than NR for NAFLD in Mice
A recent study investigated the effects of oral NMN and NR supplementation in mice with nonalcoholic fatty liver disease (NAFLD). Key Points NMN and NR provided benefits in mice on...
NMN More Effective Than NR for NAFLD in Mice
A recent study investigated the effects of oral NMN and NR supplementation in mice with nonalcoholic...
NMN and NR Alleviate Ovarian Aging in Rats
A recent study investigated the effects of NMN and NR on ovary health and function in middle-aged rats. “This study reveals that NMN alone or NR alone can rebalance mitochondrial...
NMN and NR Alleviate Ovarian Aging in Rats
A recent study investigated the effects of NMN and NR on ovary health and function in...
Liposomal delivery of NR shows increased bioava...
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially to the brain."
Liposomal delivery of NR shows increased bioava...
"Liposome-based NR loading is an effective strategy for improving the pharmacokinetics and bioavailability of NR, especially...
Niacin, NMN, and NR Are Not The Same
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within the body are distinct. Understanding these individual pathways is crucial, as they may have...
Niacin, NMN, and NR Are Not The Same
While all three precursors – Niacin, NR, and NMN – elevate NAD+ levels, their journeys within...