Research
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have been leading choices for raising NAD+ levels. Their popularity stems from the limitations of...
Oral NAD+: Revisiting Assumptions about Efficacy
Image source: Alegre, et al., 2025 For years, NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) have...
Safety Trial Favors High Dose NMN
Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects “The aim of this study was to confirm the safety of our manufactured NMN...
Safety Trial Favors High Dose NMN
Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects...
NAD+ as a Multi-Target Therapy for Neurodegener...
Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic potential Early human trials indicate promising clinical benefits Brain delivery and individual response differences...
NAD+ as a Multi-Target Therapy for Neurodegener...
Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic...
Mouse Study Shows Organ-Specific Effects of NAD...
Key Points: Liver & Kidneys: PnCA increased NAD+ levels, improved mitochondrial function, and delayed aging markers in older mice Heart & Brain: PnCA reduced NAD+ levels, worsened aging markers,...
Mouse Study Shows Organ-Specific Effects of NAD...
Key Points: Liver & Kidneys: PnCA increased NAD+ levels, improved mitochondrial function, and delayed aging...
Latest Breakthroughs in NAD+ Research: What the...
NMN, NR, and NAD+: A Brief Refresher NAD+ is an important molecule found in virtually every cell of your body, which is required for DNA repair, energy production, metabolism, and...
Latest Breakthroughs in NAD+ Research: What the...
NMN, NR, and NAD+: A Brief Refresher NAD+ is an important molecule found in virtually every...
NMN Transporters and eNAMPT: Key Regulators of ...
“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, is now proposed, featuring multi-layered feedback loops mediated by NMN and eNAMPT for mammalian aging...
NMN Transporters and eNAMPT: Key Regulators of ...
“With these exciting developments, the further reformulated version of the concept, the NAD World 3.0, is...
A Novel NAD+ Precursor (NRH) Improves Glucose a...
“To our knowledge, this is the first report showing that NRH can reach multiple tissues intact and provide a broad spectrum of effects through potent NAD+ enhancement and subsequent SIRT...
A Novel NAD+ Precursor (NRH) Improves Glucose a...
“To our knowledge, this is the first report showing that NRH can reach multiple tissues intact...
Increased NAD+ Turnover, Minor Decline in Level...
“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and degradation, supporting the rationale for NAD+ augmentation to attenuate disease severity.”
Increased NAD+ Turnover, Minor Decline in Level...
“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and degradation,...
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more tolerable.”
NR IV Exhibits Faster NAD+ Rise and Better Tole...
“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more...
NAD+ Nanoparticle Injection Decreased Blood Ves...
A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of smooth muscle cells and improved blood vessel healing in rats with narrowed arteries.
NAD+ Nanoparticle Injection Decreased Blood Ves...
A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of...
Neuroprotective Effects of NAD+ Nasal Spray
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast...
Neuroprotective Effects of NAD+ Nasal Spray
"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to...
NAD+ Injections Guard Against Heart Failure in ...
“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”
NAD+ Injections Guard Against Heart Failure in ...
“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy...