Scientific Evidence Library

Want to stay up to date on the latest in longevity science?

Join our research-focused newsletter for simple, timely insights.

Scientific Evidence Library

article-page-carousel-item--Efficacy and Safety of NAD+ Precursors in Clinical Trials

Efficacy and Safety of NAD+ Precursors in ...

4 min

A recent systematic review evaluated ten studies with NAD+ precursors for efficacy and safety.

4 min

Efficacy and Safety of NAD+ Precursors in Clini...

A recent systematic review evaluated ten studies with NAD+ precursors for efficacy and safety.

article-page-carousel-item--NR Regulates the Cardiac Internal Clock of Aged Mice

NR Regulates the Cardiac Internal Clock of...

2 min

Circadian rhythm is your body's internal clock that permits anticipation of daily patterns, regulating when it's time to sleep, wake up, eat, and digest. This study evaluated the effects of...

2 min

NR Regulates the Cardiac Internal Clock of Aged...

Circadian rhythm is your body's internal clock that permits anticipation of daily patterns, regulating when it's...

article-page-carousel-item--Novel Delivery System Improves NMN Absorption in Mice

Novel Delivery System Improves NMN Absorpt...

4 min

“Upon oral administration, NMN–HAP nanoparticles demonstrated prolonged circulation time and enhanced bioavailability compared with free NMN, leading to elevated plasma levels of both NAD+ and its precursor, NR.”

4 min

Novel Delivery System Improves NMN Absorption i...

“Upon oral administration, NMN–HAP nanoparticles demonstrated prolonged circulation time and enhanced bioavailability compared with free NMN,...

article-page-carousel-item--NMN Reduces Heart Failure and Extends Lifespan in Mice

NMN Reduces Heart Failure and Extends Life...

3 min

“These results suggest that NMN treatment functionally ameliorated or prevented exacerbation of heart failure in p32 cardiomyocyte–specific knockout mice, thereby prolonging their lifespan.”

3 min

NMN Reduces Heart Failure and Extends Lifespan ...

“These results suggest that NMN treatment functionally ameliorated or prevented exacerbation of heart failure in p32...

article-page-carousel-item--NMN Improves Blood Pressure in Humans with Hypertension

NMN Improves Blood Pressure in Humans with...

5 min

“Overall, the present study may shed new light on novel strategies in which NAD+ boosting therapy, including NMN supplement and CD38 inhibition, may turn out to be a promising therapeutic...

5 min

NMN Improves Blood Pressure in Humans with Hype...

“Overall, the present study may shed new light on novel strategies in which NAD+ boosting therapy,...

article-page-carousel-item--Study Reveals New Technique to Quickly and Accurately Measure Blood NAD+ Levels

Study Reveals New Technique to Quickly and...

5 min

Highlights A new technique has been developed to rapidly and effectively measure blood NAD+ levels in humans. Aerobic exercise and NMN supplementation increase NAD+ levels Gender- and age- variations in...

5 min

Study Reveals New Technique to Quickly and Accu...

Highlights A new technique has been developed to rapidly and effectively measure blood NAD+ levels in...

article-page-carousel-item--Anti-Aging Effects of NMN - Human Clinical Trials Review

Anti-Aging Effects of NMN - Human Clinical...

6 min

Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.

6 min

Anti-Aging Effects of NMN - Human Clinical Tria...

Resveratrol supplementation effectively protected mice against age-related muscle mass loss, heart cell enlargement, and motor dysfunction.

article-page-carousel-item--Study Shows NR Injections Increase Muscle NAD+ in Mice, Oral Supplementation Does Not

Study Shows NR Injections Increase Muscle ...

2 min

NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue. A ~140% increase in muscle NAD+ was observed after 7 days of IV administration of NR. Oral administration...

2 min

Study Shows NR Injections Increase Muscle NAD+ ...

NR injections boosted NAD+ levels in skeletal muscle and white adipose tissue. A ~140% increase in...

article-page-carousel-item--NMN Human Trial Shows Increased Endurance, NAD+ Blood Levels, and Benefits to Bioage

NMN Human Trial Shows Increased Endurance,...

3 min

Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels are known to decline with age, affecting longevity and age-related health conditions, better known...

3 min

NMN Human Trial Shows Increased Endurance, NAD+...

Study set out to determine safety and efficacy of NMN supplementation in 4 groups NAD+ levels...

article-page-carousel-item--NAD Precursors Cycle Between Host Tissues and the Gut Microbiome

NAD Precursors Cycle Between Host Tissues ...

2 min

Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both NAD and NA synthesis. Thus, gut microbiota provide an alternative route from NAM to...

2 min

NAD Precursors Cycle Between Host Tissues and t...

Thus, circulating host NAM enters the gut lumen and is used by the microbiome for both...

article-page-carousel-item--Dogs and Humans Share Same Benefits from NMN Supplementation

Dogs and Humans Share Same Benefits from N...

2 min

Dog and human NAD+ levels both decline with age Dogs have the same problem as humans in that their NAD+ levels decline with age in various critical organs, such as...

2 min

Dogs and Humans Share Same Benefits from NMN Su...

Dog and human NAD+ levels both decline with age Dogs have the same problem as humans...

article-page-carousel-item--NMN and Resveratrol Work Synergistically to boost NAD+ in Heart and Skeletal Muscle

NMN and Resveratrol Work Synergistically t...

2 min

A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+ levels in both heart and skeletal muscle tissues in mice. Combination treatments shown to...

2 min

NMN and Resveratrol Work Synergistically to boo...

A new study shows that the combination of NMN and Resveratrol works synergistically to increase NAD+...