Scientific Evidence Library

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Scientific Evidence Library

article-page-carousel-item--Safety Trial Favors High Dose NMN

Safety Trial Favors High Dose NMN

2 min

Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects “The aim of this study was to confirm the safety of our manufactured NMN...

2 min

Safety Trial Favors High Dose NMN

Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects...

article-page-carousel-item--NAD+ as a Multi-Target Therapy for Neurodegenerative Diseases: A Review of the Evidence

NAD+ as a Multi-Target Therapy for Neurode...

5 min

Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic potential Early human trials indicate promising clinical benefits Brain delivery and individual response differences...

5 min

NAD+ as a Multi-Target Therapy for Neurodegener...

Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic...

article-page-carousel-item--Mouse Study Shows Organ-Specific Effects of NAD+ Modulation on Aging

Mouse Study Shows Organ-Specific Effects o...

3 min

Key Points:   Liver & Kidneys: PnCA increased NAD+ levels, improved mitochondrial function, and delayed aging markers in older mice Heart & Brain: PnCA reduced NAD+ levels, worsened aging markers,...

3 min

Mouse Study Shows Organ-Specific Effects of NAD...

Key Points:   Liver & Kidneys: PnCA increased NAD+ levels, improved mitochondrial function, and delayed aging...

article-page-carousel-item--A Novel NAD+ Precursor (NRH) Improves Glucose and Fat Metabolism in Obese Mice

A Novel NAD+ Precursor (NRH) Improves Gluc...

7 min

“To our knowledge, this is the first report showing that NRH can reach multiple tissues intact and provide a broad spectrum of effects through potent NAD+ enhancement and subsequent SIRT...

7 min

A Novel NAD+ Precursor (NRH) Improves Glucose a...

“To our knowledge, this is the first report showing that NRH can reach multiple tissues intact...

article-page-carousel-item--Increased NAD+ Turnover, Minor Decline in Levels in COVID-19 Patients

Increased NAD+ Turnover, Minor Decline in ...

4 min

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and degradation, supporting the rationale for NAD+ augmentation to attenuate disease severity.”

4 min

Increased NAD+ Turnover, Minor Decline in Level...

“NAD+ turnover is substantially increased with upregulation of genes involved in both NAD+ biosynthesis and degradation,...

article-page-carousel-item--NR IV Exhibits Faster NAD+ Rise and Better Tolerability in Humans

NR IV Exhibits Faster NAD+ Rise and Better...

5 min

“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more tolerable.”

5 min

NR IV Exhibits Faster NAD+ Rise and Better Tole...

“In comparison to NAD+ IV, NR IV was infused faster, and the infusion experience was more...

article-page-carousel-item--NAD+ Nanoparticle Injection Decreased Blood Vessel Damage In Rats

NAD+ Nanoparticle Injection Decreased Bloo...

3 min

A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of smooth muscle cells and improved blood vessel healing in rats with narrowed arteries.

3 min

NAD+ Nanoparticle Injection Decreased Blood Ves...

A new study found injection of NAD+ using a novel liposome-like nano-particle carrier reduced overgrowth of...

article-page-carousel-item--Neuroprotective Effects of NAD+ Nasal Spray

Neuroprotective Effects of NAD+ Nasal Spray

3 min

"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to brain tissues, thereby circumventing the hepatic first-pass metabolism and gastric degradation and allowing fast...

3 min

Neuroprotective Effects of NAD+ Nasal Spray

"Compared to traditional routes, the nasal administration of drugs can direct the rapid CNS absorption to...

article-page-carousel-item--NAD+ Injections Guard Against Heart Failure in Rats and Beagles

NAD+ Injections Guard Against Heart Failur...

4 min

“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy and cardiac function, inhibits myocardial fibrosis, and reduces the myocardial infarction rate.”

4 min

NAD+ Injections Guard Against Heart Failure in ...

“This study, involving rat and beagle MI-induced HF models, indicated that NAD+ significantly improves myocardial hypertrophy...

article-page-carousel-item--Extracellular NAD+ Suppresses Inflammatory Response

Extracellular NAD+ Suppresses Inflammatory...

3 min

A recent literature review explored the impact of extracellular NAD+ on the inflammatory response.

3 min

Extracellular NAD+ Suppresses Inflammatory Resp...

A recent literature review explored the impact of extracellular NAD+ on the inflammatory response.

article-page-carousel-item--NAD+ IV Infusion Enhanced Recovery in Heart Failure Patients

NAD+ IV Infusion Enhanced Recovery in Hear...

3 min

This study evaluated the effects of NAD+ injections in patients with heart failure.

3 min

NAD+ IV Infusion Enhanced Recovery in Heart Fai...

This study evaluated the effects of NAD+ injections in patients with heart failure.

article-page-carousel-item--High-Dose NR is Safe & Does Not Deplete Methyl Pools in PD Trial

High-Dose NR is Safe & Does Not Deplete Me...

4 min

This study evaluated the safety and effects of high-dose (3,000 mg) Nicotinamide Riboside (NR) supplementation in patients with Parkinson’s Disease (PD).

4 min

High-Dose NR is Safe & Does Not Deplete Methyl ...

This study evaluated the safety and effects of high-dose (3,000 mg) Nicotinamide Riboside (NR) supplementation in...