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Scientific Evidence Library
Inhibition of CD38 Increases NAD+ Levels
Inhibition of CD38 Increases NAD+ and Extends Lifespan and Healthspan Two recent studies have found that inhibition of CD38 (with 78c or PCC1) increase NAD+ levels and result in significant...
Inhibition of CD38 Increases NAD+ Levels
Inhibition of CD38 Increases NAD+ and Extends Lifespan and Healthspan Two recent studies have found that...
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice daily, NMN triples NAD+ levels (right graph). Dr. David Sinclair is a co-founder of...
NMN Triples NAD+ Levels in Humans
NMN doses of 1,000 mg taken once daily doubles NAD+ levels (middle graph). When taken twice...
Study Shows NMN Supplementation or CD38 Inhibit...
Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It was demonstrated that raising NAD+ levels through NMN supplementation or by CD38 inhibition can restore cardiovascular function...
Study Shows NMN Supplementation or CD38 Inhibit...
Declining NAD+ levels are a major contributor to cardiovascular disease in mice. It was demonstrated that...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver, 4 hours after a single dose of either 50mg/kg or 500 mg/kg by oral...
Bacteria in Gastrointestional Tract Metabolize ...
Several experiments were completed that all measured NAD+ metabolites in the Gastrointestinal Tract (GIT) and Liver,...
CD73 utilization shows importance of NMN to res...
Like prior studies (1), they found that this transport method did not impede NMN from entering cells, as NR and NMN performed equally at restoring NAD+. They also determined that...
CD73 utilization shows importance of NMN to res...
Like prior studies (1), they found that this transport method did not impede NMN from entering...
Case Study on Liposomal NMN Shows Positive Impa...
βIn an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited remarkable protective effects against hepatic tissue damage, steatosis, inflammation, insulin resistance, and hepatocellular enzyme...
Case Study on Liposomal NMN Shows Positive Impa...
βIn an animal model of type 2 diabetes, the intragastric delivery of Lip-BBR via liposomes exhibited...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be...
1st NMN Human Study Demonstrates Safety and Fas...
The single oral administration of NMN was safe and effectively metabolized in healthy men without causing...
NAD+ IV increases NAD+ levels in blood plasma 4...
In summary, this study revealed for the first time that: (a) at a flow rate of 3 ΞΌmole/min all exogenously infused NAD+ was rapidly and completely removed from the plasma...
NAD+ IV increases NAD+ levels in blood plasma 4...
In summary, this study revealed for the first time that: (a) at a flow rate of...
Increased NAD+ in Bloodstream of Nursing Mice R...
These improvements in health and behavior persisted for the length of the study, which was 90 days after birth. Some quotes from the study: Adding NR to normal chow (NC)...
Increased NAD+ in Bloodstream of Nursing Mice R...
These improvements in health and behavior persisted for the length of the study, which was 90...
Scientists discover SLC12a8 pathway used by NMN...
More details about the research Slc12a8 in the small intestine is important for transporting NMN from the gut into the circulation, affecting NAD+ levels in the small intestine and the...
Scientists discover SLC12a8 pathway used by NMN...
More details about the research Slc12a8 in the small intestine is important for transporting NMN from...
NAD+ Supplements Regulate Energy Metabolism via...
This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier to enter the hypothalamus INTACT, increases NAD+ levels, reduces hunger and weight gain, and...
NAD+ Supplements Regulate Energy Metabolism via...
This study shows that administration of 1 mg/kg of LABELED NAD+ crosses the blood brain barrier...
Exogenous NAD+ Increases Metabolism
In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter peritoneal injection for 4 weeks, which restored NAD+ levels in the hypothalamus to normal...
Exogenous NAD+ Increases Metabolism
In a study published in 2018, scientists gave obese mice 1 mg/kg of NAD+ by inter...