Scientific Evidence Library

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Scientific Evidence Library

article-page-carousel-item--Liposomal NAD+ Enhances Delivery and Reduces Aging in Skin and Blood Vessel Cells

Liposomal NAD+ Enhances Delivery and Reduc...

5 min

Key Points Boosted NAD+ in human blood vessel cells Reduced cellular aging (senescent cells) by 28.7% Decreased key aging markers (p16 and p21) Improved cell survival Delivered 30% more NAD+...

5 min

Liposomal NAD+ Enhances Delivery and Reduces Ag...

Key Points Boosted NAD+ in human blood vessel cells Reduced cellular aging (senescent cells) by 28.7%...

article-page-carousel-item--Resveratrol and NMN Restore Brain Metabolism and Reduce Inflammation in Smoke-Exposed Aged Mice

Resveratrol and NMN Restore Brain Metaboli...

4 min

Key Points Wood smoke impaired brain chemistry and behavior Resveratrol + NMN provided the strongest protection Combination therapies showed mixed results NAD+ proved to be a key target for protecting...

4 min

Resveratrol and NMN Restore Brain Metabolism an...

Key Points Wood smoke impaired brain chemistry and behavior Resveratrol + NMN provided the strongest protection...

article-page-carousel-item--NMN Outperforms NR and Other NAD+ Precursors in Skin Cells

NMN Outperforms NR and Other NAD+ Precurso...

6 min

Key Points NMN outperformed NR and NAM, triggering stronger skin cell protection Cellular aging slowed through improved energy and repair activity Mitochondrial health and energy production were preserved Collagen production...

6 min

NMN Outperforms NR and Other NAD+ Precursors in...

Key Points NMN outperformed NR and NAM, triggering stronger skin cell protection Cellular aging slowed through...

article-page-carousel-item--Emerging Strategies, Applications, and Challenges of Targeting NAD⁺ in the Clinic: A Review

Emerging Strategies, Applications, and Cha...

11 min

Once regarded as a simple coenzyme required for energy production, NAD⁺ is now recognized as a master regulator of health, supporting DNA repair, epigenetic programming, immune responses, and mitochondrial function....

11 min

Emerging Strategies, Applications, and Challeng...

Once regarded as a simple coenzyme required for energy production, NAD⁺ is now recognized as a...

article-page-carousel-item--Novel Longevity Therapy Extends Life and Health in Old, Frail Mice

Novel Longevity Therapy Extends Life and H...

6 min

A groundbreaking new study from UC Berkeley reports that combining oxytocin (OT) with an Alk5 inhibitor (A5i) dramatically extended lifespan and healthspan in old frail male mice - showing the...

6 min

Novel Longevity Therapy Extends Life and Health...

A groundbreaking new study from UC Berkeley reports that combining oxytocin (OT) with an Alk5 inhibitor...

article-page-carousel-item--The Complete Guide to Choosing  Your Optimal NMN Formula:  Evidence-Based  Recommendations for  Personalized NAD+ Support

The Complete Guide to Choosing Your Optim...

11 min

NAD+ Decline: Why Supplementation Matters NAD+ is a critical coenzyme in hundreds of cellular processes, including energy production (glycolysis, citric acid cycle, oxidative phosphorylation), DNA repair through PARP activation, sirtuin-mediated...

11 min

The Complete Guide to Choosing Your Optimal NM...

NAD+ Decline: Why Supplementation Matters NAD+ is a critical coenzyme in hundreds of cellular processes, including...

article-page-carousel-item--NMN Improves Movement and Brain Health in a Parkinson’s Disease Mouse Model

NMN Improves Movement and Brain Health in ...

5 min

Key Points: NMN restored NAD+ levels and improved motor performance in Parkinson’s disease (PD) model mice. It reduced inflammation, prevented synaptic loss, and lowered harmful brain immune activity (gliosis). The...

5 min

NMN Improves Movement and Brain Health in a Par...

Key Points: NMN restored NAD+ levels and improved motor performance in Parkinson’s disease (PD) model mice....

article-page-carousel-item--Nicotinamide Riboside Shows Promise in Treating Premature Aging in Humans

Nicotinamide Riboside Shows Promise in Tre...

3 min

“Depletion of nicotinamide adenine dinucleotide (NAD)+ has been reported in patients with WS, suggesting a key role in the pathogenesis of WS.” Key Points No serious adverse effects reported NR...

3 min

Nicotinamide Riboside Shows Promise in Treating...

“Depletion of nicotinamide adenine dinucleotide (NAD)+ has been reported in patients with WS, suggesting a key...

article-page-carousel-item--Safety Trial Favors High Dose NMN

Safety Trial Favors High Dose NMN

2 min

Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects “The aim of this study was to confirm the safety of our manufactured NMN...

2 min

Safety Trial Favors High Dose NMN

Key Points No adverse effects observed NAD+ levels increased significantly Overdose levels had no side effects...

article-page-carousel-item--NR Improved Brain and Blood Vessel Health in Adults with PAD

NR Improved Brain and Blood Vessel Health ...

2 min

Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased in areas linked to memory and decision-making Participants showed modest gains in cognitive tests,...

2 min

NR Improved Brain and Blood Vessel Health in Ad...

Key Points Blood vessel function improved after 4 weeks of NR supplementation Brain blood flow increased...

article-page-carousel-item--Safety of IV Nicotinamide Riboside at Different Doses in Rats

Safety of IV Nicotinamide Riboside at Diff...

1 min

Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600 mg/kg) caused negative effects, including cardiovascular, liver, and kidney damage Increasing Doses of IV...

1 min

Safety of IV Nicotinamide Riboside at Different...

Key Points IV NR was well tolerated at doses up to 450 mg/kg High doses (600...

article-page-carousel-item--NAD+ as a Multi-Target Therapy for Neurodegenerative Diseases: A Review of the Evidence

NAD+ as a Multi-Target Therapy for Neurode...

5 min

Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic potential Early human trials indicate promising clinical benefits Brain delivery and individual response differences...

5 min

NAD+ as a Multi-Target Therapy for Neurodegener...

Key Points NAD+ decline is tied to key drivers of NDDs Animal studies show strong therapeutic...