90 Capsules Allergen-Free

Serving size 1 capsule

LIPO Glutathione

Name: LIPO Glutathione
Brand: Renue Store
SKU: 850055685161
Price: 51.95 USD
Availability: InStock

High absorption form of the master antioxidant

$51.95 USD

Shipping calculated at checkout.

Glutathione is a remarkably essential longevity molecule.

Found in nearly every cell, this antioxidant is central to detoxification, cellular repair, and immune balance.† Yet, its bioavailability in traditional supplements is limited due to breakdown in the digestive tract.

LIPO Glutathione features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect it from digestive enzymes and carry them into the bloodstream for targeted systemic delivery.

LIPO Glutathione is also available in our combination formula, Restore PM.

Product variants

90 Capsules Allergen-Free

Serving size 1 capsule

Liposomal Glutathione

Glutathione is a naturally occurring intracellular antioxidant found abundantly in nearly every cell in your body. This potent molecule plays such a crucial role in your body. There is increasing awareness of its utility in mitigating the body’s toxin load. 3

The Master Antioxidant

Known as the “Master Antioxidant,” its levels decrease as a result of aging, stress, and toxin exposure.

Because glutathione can be broken down rapidly in the digestive tract, it is important to select a glutathione supplement that is formulated to survive exposure to digestive enzymes and be well absorbed.

The liposomes surround each molecule and protect the core ingredients from the digestive system while increasing its transport and uptake by your cells.

Research Reveals Liposomal Glutathione Is More Effective

Clinical research aiming to improve Glutathione concentration requires sufficient Glutathione absorption and delivery.

Results from two recent studies showed that liposomal formulation is more effective at raising blood Glutathione levels in humans than non-liposomal Glutathione. 1,2

Both studies report a very rapid decline in the bioavailability of non-liposome-encapsulated Glutathione compared to liposomal Glutathione.

Liposomal Delivery

LIPO Glutathione uses a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.

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The Healer Within

Glutathione is often called the “Master Antioxidant” for good reason. As the body’s primary intracellular antioxidant, it protects your cells from oxidative stress, supports energy production, and ensures the proper functioning of other antioxidants like vitamins C and E.†

Its importance goes far beyond antioxidant activity. Glutathione is integral to detoxification pathways, immune regulation, and mitochondrial function, making it one of the most versatile molecules in human biology.† However, as we age, significant changes in glutathione levels, utilization, and demand occur, which can impact overall cellular health and resilience.

As we age, glutathione demand goes up while production goes down.

Decreasing Glutathione Stores

Research shows that glutathione levels decline steadily with age, with reductions observed in various tissues, including the liver, lungs, and extensively in the brain. Studies suggest that by middle age, glutathione levels may be significantly reduced, and this depletion accelerates in later decades. Lower glutathione reserves weaken the body’s ability to neutralize oxidative damage,
leaving cells vulnerable to environmental stressors and internal metabolic byproducts. (1, 2, 3)

Increased Utilization with Age

As oxidative stress increases with aging, the demand for glutathione also rises. Cells must use more glutathione to neutralize the higher levels of reactive oxygen species (ROS) generated by mitochondrial dysfunction, chronic inflammation, and environmental toxin exposure. This increased utilization outpaces the body’s natural ability to replenish glutathione stores, exacerbating the depletion. (1, 2, 3)

Greater Demand for Detoxification

With aging, the body’s ability to process and eliminate toxins often becomes less efficient, partly due to the decreasing efficiency of the liver—the central organ for detoxification. As glutathione is a critical component of the liver’s Phase II detoxification pathways, its demand rises in proportion to the increased burden of clearing harmful compounds. Insufficient glutathione synthesis and recycling can impair these processes, potentially leading to the accumulation of toxins that further strain the system. (1, 2, 3)

Impaired Synthesis and Recycling

Glutathione synthesis is a complex process involving the availability of precursor amino acids (glutamate, cysteine, and glycine) and enzymatic activity. With aging, factors such as reduced dietary intake of precursors, lower enzymatic activity, and increased oxidative stress impair both the synthesis and recycling of glutathione. This creates a cycle of decreased supply and increased demand, compounding the challenges of maintaining adequate levels. (1, 2, 3)

Glutathione protects youthful function.

Glutathione plays a central role in maintaining the body's resilience against aging processes, making it a cornerstone of cellular longevity. Healthy glutathione levels are associated with key mechanisms that support longevity and overall vitality:

Cellular Resilience

Mitochondria are the powerhouses of the cell as you’ve heard in every high school biology class, responsible for energy production and cellular metabolism as well as signaling within and between cells. With age, mitochondrial function often declines, leading to increased oxidative damage and reduced energy efficiency. Glutathione is critical for maintaining mitochondrial health by neutralizing reactive oxygen species (ROS) and protecting against oxidative damage within these organelles. (1)

DNA Integrity

Oxidative stress, caused by the accumulation of free radicals, is a major driver of DNA damage and genetic instability. Glutathione shields cells against this damage by scavenging free radicals and maintaining the redox balance essential for DNA repair mechanisms. Its role in reducing oxidative
stress directly contributes to preserving genetic stability over time. (2)

Immune System Support

The immune system's efficiency declines with age, a phenomenon known as immunosenescence. Glutathione supports healthy immune resilience by protecting T-cell function, preserving the normal activity of natural killer (NK) cells, and calming chronic inflammation. By supporting a robust and youthful immune response, glutathione helps the body adapt to environmental and internal stressors, maintaining immune balance as you age. (4)

Liposomal Delivery Maximizes Bioavailability

Protecting glutathione within biocompatible phospholipid liposomes promotes absorption and utilization.

One of the biggest challenges with glutathione supplementation is its poor bioavailability. Traditional oral glutathione is rapidly degraded by digestive enzymes, limiting the amount that enters the
bloodstream and reaches cells. Liposomal glutathione overcomes this limitation through an advanced delivery system that dramatically enhances absorption and utilization.

Enhanced Absorption and Cellular Delivery

A study published in Nutrients demonstrated that liposomal glutathione significantly raises blood glutathione levels compared to non-liposomal forms. The lipid-based encapsulation protects glutathione from digestive breakdown, allowing it to be absorbed intact and transported directly
into the bloodstream. This efficient delivery system ensures that a greater percentage of the active compound reaches target tissues. (7)

Sustained Blood Levels for Prolonged Effectiveness

The benefits of liposomal delivery go beyond initial absorption. A 2019 study in Redox Biology revealed that liposomal glutathione not only increases blood glutathione concentrations but also
sustains them over a longer period. This prolonged availability amplifies glutathione's antioxidant and detoxification effects, providing continuous cellular support. (8)

How Liposomes Work

Liposomal technology encapsulates glutathione in microscopic lipid spheres made of phospholipids.

These liposomes:

Protect Glutathione Molecules: Protect against degradation by stomach acid and digestive enzymes.

Facilitate Efficient Absorption: Facilitate transport across intestinal walls into the bloodstream.

Enhance Cellular Uptake: Deliver glutathione directly into cells by merging with cell membranes.

By ensuring higher and sustained blood levels of glutathione, liposomal technology maximizes the molecule’s ability to combat oxidative stress, support detoxification, and promote overall cellular
health—making it the benchmark for glutathione longevity formulas.

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LIPO Glutathione

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Certifications

Supported by Science

Purest Ingredients

All our products are non-GMO and 100% free from preservatives, artificial colours, flavours and sweeteners.

Advanced Testing

We use pharmaceutical-grade testing procedures and our products have to pass through 4 rounds of testing.

Certified Labs

Our products are tested in ISO-Certified and cGMP certified labs for ultimate quality, purity and potency.

Strength and Purity Certification Gold Standard Testing Glutathione Report

Frequently Asked Questions

What are the benefits of liposomal delivery? Are liposomes really better?

When taken sublingually, approximately 30% of a 125 mg dose gets absorbed under the tongue, with the remainder being swallowed. At higher dosages, the % goes down, as the capillaries are full and have limited transport.

A much greater % makes it to bloodstream with liposomal delivery. Liposomes also protect the payload from degradation once in the bloodstream.

Lastly, Liposomes release the payload over a much longer period – up to 24 hours. This is better when taking larger dosages.

The rapid delivery to the bloodstream with Sublingual can be an advantage when taking before exercise. The energy surge most users feel is also nice confirmation that it is doing something.

What are the liquid and powdered liposome differences in bioavailability and stability?

Our liquid and powdered liposomes have approximately the same availability in the bloodstream, but the powdered liposomes release the payload more slowly over 24 hours. We don’t know if that makes it more effective than a faster release.

Powdered liposomal products have a shelf life of over two years, rather than the 12 months or so for liquid liposomal products when stored at room temp.

What's the difference between Liposomal vs. Delayed & Extended Release Caps?

Delayed Release & Extended Release Caps protect ingredients from stomach acid only. They delay, but don't really sustain ingredient release.

Liposomes protect the payload through the GI tract and into the bloodstream, then release more slowly up to 24 hours (depending on the liposome).

In addition to a big increase in bioavailability, they are truly sustained release. Any supplement known to have poor bioavailability should use liposomal delivery.

Are any of your liposomal products heat-sensitive?

The liposomal powder capsule products are not heat sensitive.

The liposomal gels however should not be exposed to heat exceeding 115 degrees Fahrenheit for more than a few days. Liposomes break down a bit when exposed to extended periods of high heat.